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Chlorthalidone

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Overview

What is Chlorthalidone?

Chlorthalidone is an oral antihypertensive/diuretic. It is a monosulfamyl diuretic that differs chemically from thiazide diuretics in that a double-ring system is incorporated in its structure. It is 2-chloro-5(1-hydroxy-3-oxo-1- isoindolinyl) benzenesulfonamide with the following structural formula:

Molecular Formula: CHClNOS

Molecular weight: 338.76

Chlorthalidone, USP is practically insoluble in water, in ether, and in chloroform; soluble in methanol; slightly soluble in ethanol.

Chlorthalidone tablets are available containing 25 mg of chlorthalidone USP and the following inactive ingredients: colloidal silicon dioxide, microcrystalline cellulose, D and C Yellow No.10, sodium starch glycolate, pregelatinized starch, stearic acid and other inactive ingredients.



What does Chlorthalidone look like?



What are the available doses of Chlorthalidone?

Sorry No records found.

What should I talk to my health care provider before I take Chlorthalidone?

Sorry No records found

How should I use Chlorthalidone?

Diuretics such as chlorthalidone are indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effect of other antihypertensive drugs in the more severe forms of hypertension.

Chlorthalidone is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy.

Chlorthalidone has also been found useful in edema due to various forms of renal dysfunction, such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure.

Therapy should be initiated with the lowest possible dose. This dose should be titrated according to individual patient response to gain maximal therapeutic benefit while maintaining lowest dosage possible. A single dose given in the morning with food is recommended; divided daily doses are unnecessary.

Initiation:

Maintenance:

Initiation:

Maintenance:


What interacts with Chlorthalidone?

Anuria.


Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.



What are the warnings of Chlorthalidone?

Sorry No Records found


What are the precautions of Chlorthalidone?

Sorry No Records found


What are the side effects of Chlorthalidone?

The following adverse reactions have been observed, but there is not enough systematic collection of data to support an estimate of their frequency.

Gastrointestinal System Reactions:

Central Nervous System Reactions:

Hematologic Reactions:

Dermatologic-Hypersensitivity Reactions:

Cardiovascular Reactions:

Other Adverse Reactions:

Whenever adverse reactions are moderate or severe, chlorthalidone dosage should be reduced or therapy withdrawn.


What should I look out for while using Chlorthalidone?

Anuria.

Known hypersensitivity to chlorthalidone or other sulfonamide-derived drugs.

Chlorthalidone should be used with caution in severe renal disease. In patients with renal disease, chlorthalidone or related drugs may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function.

Chlorthalidone should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Sensitivity reactions may occur in patients with a history of allergy or bronchial asthma.

The possibility of exacerbation or activation of systemic lupus erythematosus has been reported with thiazide diuretics, which are structurally related to chlorthalidone. However, systemic lupus erythematosus has not been reported following chlorthalidone administration.


What might happen if I take too much Chlorthalidone?

Symptoms of acute overdosage include nausea, weakness, dizziness, and disturbances of electrolyte balance. The oral LD of the drug in the mouse and the rat is more than 25,000 mg/kg body weight. The minimum lethal dose (MLD) in humans has not been established. There is no specific antidote, but gastric lavage is recommended, followed by supportive treatment. Where necessary, this may include intravenous dextrose-saline with potassium, administered with caution.


How should I store and handle Chlorthalidone?

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Chlorthalidone Tablets, USP are available containing 25 mg USP.The 25 mg tablets are light yellow, round, unscored tablets debossed with on one side of the tablet and blank on the other side. They are available as follows:NDC 0179-0015-01bottles of 100 tabletsStore at 20° to 25°C (68° to 77°F). [See USP for Controlled Room Temperature.]Protect from light.Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.