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Levofloxacin

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Overview

What is Levofloxacin?

Levofloxacin tablets, USP is a synthetic broad-spectrum antibacterial agent for oral and intravenous administration. Chemically, levofloxacin, USP, a chiral fluorinated carboxyquinolone, is the pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin. The chemical name is (-)-(S)-9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid hemihydrate.

Figure

1:

The

Chemical

Structure

of

Levofloxacin

The empirical formula is CHFNO • ½ HO and the molecular weight is 370.38.

Levofloxacin, USP is a light yellowish-white to yellow-white crystal or crystalline powder. The molecule exists as a zwitterion at the pH conditions in the small intestine.

The data demonstrate that from pH 0.6 to 5.8, the solubility of levofloxacin, USP is essentially constant (approximately 100 mg/mL). Levofloxacin, USP is considered     in this pH range, as defined by USP nomenclature. Above pH 5.8, the solubility increases rapidly to its maximum at pH 6.7 (272 mg/mL) and is considered   in this range. Above pH 6.7, the solubility decreases and reaches a minimum value (about 50 mg/mL) at a pH of approximately 6.9.

Levofloxacin, USP has the potential to form stable coordination compounds with many metal ions.

This in vitro chelation potential has the following formation order: Al+3>Cu+2>Zn+2>Mg+2>Ca+2.

Excipients

and

Description

of

Dosage

Forms

Levofloxacin tablets are available as film-coated tablets and contain the following inactive ingredients:



What does Levofloxacin look like?



What are the available doses of Levofloxacin?

TABLETS, Film-coated, capsule-shaped

What should I talk to my health care provider before I take Levofloxacin?

How should I use Levofloxacin?

Levofloxacin are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible isolates of the designated microorganisms in the conditions listed in this section.

The usual dose of levofloxacin tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1.

These recommendations apply to patients with creatinine clearance ≥ 50 mL/min. For patients with creatinine clearance <50 mL/min, adjustments to the dosing regimen are required     .


What interacts with Levofloxacin?

Sorry No Records found


What are the warnings of Levofloxacin?

Sorry No Records found


What are the precautions of Levofloxacin?

Sorry No Records found


What are the side effects of Levofloxacin?

Sorry No records found


What should I look out for while using Levofloxacin?

Known hypersensitivity to levofloxacin or other quinolones (, )


What might happen if I take too much Levofloxacin?

In the event of an acute overdosage, the stomach should be emptied. The patient should be observed and appropriate hydration maintained. Levofloxacin is not efficiently removed by hemodialysis or peritoneal dialysis.

Levofloxacin exhibits a low potential for acute toxicity. Mice, rats, dogs and monkeys exhibited the following clinical signs after receiving a single high dose of levofloxacin: ataxia, ptosis, decreased locomotor activity, dyspnea, prostration, tremors, and convulsions. Doses in excess of 1500 mg/kg orally and 250 mg/kg IV produced significant mortality in rodents.


How should I store and handle Levofloxacin?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Preserve in tight, light-resistant containers as defined in the USP.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Preserve in tight, light-resistant containers as defined in the USP.Product: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLEProduct: 50090-2892Product: 50090-2963NDC: 50090-2963-0 7 TABLET in a BOTTLENDC: 50090-2963-1 10 TABLET in a BOTTLEProduct: 50090-3013NDC: 50090-3013-0 5 TABLET in a BOTTLENDC: 50090-3013-2 10 TABLET in a BOTTLE


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Levofloxacin is a member of the fluoroquinolone class of antibacterial agents   .

Non-Clinical Toxicology
Known hypersensitivity to levofloxacin or other quinolones (, )

Aminoglutethimide:

Amphotericin B injection and potassium-depleting agents:







Anticholinesterases:

Anticoagulants, oral:

Antidiabetics:

Antitubercular drugs:

Cholestyramine:

Cyclosporine:

Digitalis glycosides:

Estrogens, including oral contraceptives:

Hepatic Enzyme Inducers (e.g., barbiturates, phenytoin, carbamazepine, rifampin):

Hepatic Enzyme Inhibitors (e.g., ketoconazole, macrolide antibiotics such as erythromycin and troleandomycin):

Ketoconazole:

Nonsteroidal anti-inflammatory agents (NSAIDs):

Skin tests:







Fluoroquinolones, including levofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions from different body systems that can occur together in the same patient. Commonly seen adverse reactions include tendinitis, tendon rupture, arthralgia, myalgia, peripheral neuropathy, and central nervous system effects (hallucinations, anxiety, depression, insomnia, severe headaches, and confusion). These reactions can occur within hours to weeks after starting levofloxacin. Patients of any age or without preexisting risk factors have experienced these adverse reactions [

Discontinue levofloxacin immediately at the first signs or symptoms of any serious adverse reaction. In addition, avoid the use of fluoroquinolones, including levofloxacin, in patients who have experienced any of these serious adverse reactions associated with fluoroquinolones.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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