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Tri-Lo-Mili

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Overview

What is Tri-Lo-Mili?

Tri-Lo-Mili is a combination oral contraceptive containing the progestational compound norgestimate and the estrogenic compound ethinyl estradiol. Norgestimate is designated as (18,19-Dinor-17-pregn-4-en-20-yn-3-one,17-(acetyloxy)-13-ethyl-, oxime,(17α)-(+)-) and ethinyl estradiol is designated as (19-nor-17α-pregna,1,3,5(10)-trien-20-yne-3,17-diol).



What does Tri-Lo-Mili look like?



What are the available doses of Tri-Lo-Mili?

Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets) consists of 21 round, biconvex, coated tablets and 7 round, mottled, biconvex, uncoated tablets in the following order ():

What should I talk to my health care provider before I take Tri-Lo-Mili?

Nursing mothers: Not recommended; can decrease milk production. ()

How should I use Tri-Lo-Mili?

Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets USP) is an estrogen/progestin COC, indicated for use by women to prevent pregnancy. ()

Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets) is dispensed in a blister pack . Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets) may be started using either a Day 1 start or a Sunday start (see Table 1). For the first cycle of a Sunday Start regimen, an additional method of contraception should be used until after the first 7 consecutive days of administration.


What interacts with Tri-Lo-Mili?

Sorry No Records found


What are the warnings of Tri-Lo-Mili?

Sorry No Records found


What are the precautions of Tri-Lo-Mili?

Sorry No Records found


What are the side effects of Tri-Lo-Mili?

Sorry No records found


What should I look out for while using Tri-Lo-Mili?

Do not prescribe Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets) to women who are known to have the following conditions:

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke .


What might happen if I take too much Tri-Lo-Mili?

There have been no reports of serious ill effects from overdosage of oral contraceptives, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.


How should I store and handle Tri-Lo-Mili?

Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:Lorazepam Tablets, USP are available containing 2 mg of lorazepam, USP.The 2 mg tablets are white to off-white, round, scored tablets debossed with above the score and below the score on one side of the tablet and blank on the other side. They are available as follows:NDC 63187-868-03bottles of 03 tabletsNDC 63187-868-05bottles of 05 tabletsNDC 63187-868-06bottles of 06 tabletsNDC 63187-868-10bottles of 10 tabletsNDC 63187-868-20bottles of 20 tablets NDC 63187-868-30bottles of 30 tabletsNDC 63187-868-60bottles of 60 tablets NDC 63187-868-90bottles of 90 tabletsStore at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]Protect from light. Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.PHARMACIST:


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Clinical Information

Chemical Structure

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Clinical Pharmacology

COCs lower the risk of becoming pregnant primarily by suppressing ovulation. Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

Non-Clinical Toxicology
Do not prescribe Tri-Lo-Mili (norgestimate and ethinyl estradiol tablets) to women who are known to have the following conditions:

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke .

The concomitant use of benzodiazepines and opioids increases the risk of respiratory depression because of actions at different receptor sites in the CNS that control respiration. Benzodiazepines interact at GABA sites and opioids interact primarily at mu receptors. When benzodiazepines and opioids are combined, the potential for benzodiazepines to significantly worsen opioid-related respiratory depression exists. Limit dosage and duration of concomitant use of benzodiazepines and opioids, and monitor patients closely for respiratory depression and sedation.

The benzodiazepines, including lorazepam tablets, produce increased CNS- depressant effects when administered with other CNS depressants such as alcohol, barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, sedative antihistamines, anticonvulsants, and anesthetics.

Concomitant use of clozapine and lorazepam may produce marked sedation, excessive salivation, hypotension, ataxia, delirium, and respiratory arrest.

Concurrent administration of lorazepam with valproate results in increased plasma concentrations and reduced clearance of lorazepam. Lorazepam dosage should be reduced to approximately 50% when coadministered with valproate.

Concurrent administration of lorazepam with probenecid may result in a more rapid onset or prolonged effect of lorazepam due to increased half-life and decreased total clearance. Lorazepam dosage needs to be reduced by approximately 50% when coadministered with probenecid.

The effects of probenecid and valproate on lorazepam may be due to inhibition of glucuronidation.

Administration of theophylline or aminophylline may reduce the sedative effects of benzodiazepines, including lorazepam.

Thromboembolic Disorders and Other Vascular Problems:

Liver disease:

High blood pressure:

Carbohydrate and lipid metabolic effects:

Headache:

Bleeding Irregularities and Amenorrhea:

The following serious adverse reactions with the use of COCs are discussed elsewhere in labeling:

Adverse reactions commonly reported by COC users are:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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