Losartan potassium Tablets, 100 mg

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Overview

What is Losartan potassium Tablets, 100 mg?

Losartan potassium is an angiotensin II receptor blocker acting on the AT receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[-(-1tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Its empirical formula is CHClKNO, and its structural formula is:

Losartan potassium, USP is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losartan potassium is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium, USP and the following inactive ingredients: microcrystalline cellulose, lactose monohydrate, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, titanium dioxide D&C yellow No. 10 aluminum lake and FD&C blue No. 2 aluminum lake.

Losartan potassium tablets 25 mg, 50 mg and 100 mg contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively.

What does Losartan potassium Tablets, 100 mg look like?

What are the available doses of Losartan potassium Tablets, 100 mg?

Tablets: 25 mg; 50 mg; and 100 mg. ()

What should I talk to my health care provider before I take Losartan potassium Tablets, 100 mg?

How should I use Losartan potassium Tablets, 100 mg?

Losartan potassium is an angiotensin II receptor blocker (ARB) indicated for:

What interacts with Losartan potassium Tablets, 100 mg?

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What are the warnings of Losartan potassium Tablets, 100 mg?

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What are the precautions of Losartan potassium Tablets, 100 mg?

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What are the side effects of Losartan potassium Tablets, 100 mg?

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What should I look out for while using Losartan potassium Tablets, 100 mg?

Losartan potassium is contraindicated:

When pregnancy is detected, discontinue Losartan potassium as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see ].

What might happen if I take too much Losartan potassium Tablets, 100 mg?

Significant lethality was observed in mice and rats after oral administration of 1000 mg/kg and 2000 mg/kg, respectively, about 44 and 170 times the maximum recommended human dose on a mg/m basis.

Limited data are available in regard to overdosage in humans. The most likely manifestation of overdosage would be hypotension and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation. If symptomatic hypotension should occur, supportive treatment should be instituted.

Neither losartan nor its active metabolite can be removed by hemodialysis.

How should I store and handle Losartan potassium Tablets, 100 mg?

Losartan potassium Tablets USP, 25 mg Losartan potassium Tablets USP, 50 mg Losartan potassium Tablets USP, 100 mg Storage Losartan potassium Tablets USP, 25 mg Losartan potassium Tablets USP, 50 mg Losartan potassium Tablets USP, 100 mg Storage Losartan potassium Tablets USP, 25 mg Losartan potassium Tablets USP, 50 mg Losartan potassium Tablets USP, 100 mg Storage Losartan potassium Tablets USP, 25 mg Losartan potassium Tablets USP, 50 mg Losartan potassium Tablets USP, 100 mg Storage

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Clinical Information

Chemical Structure

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Clinical Pharmacology

Angiotensin II [formed from angiotensin I in a reaction catalyzed by angiotensin converting enzyme (ACE, kininase II)] is a potent vasoconstrictor, the primary vasoactive hormone of the renin-angiotensin system, and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the adrenal cortex. Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland). There is also an AT receptor found in many tissues but it is not known to be associated with cardiovascular homeostasis. Neither losartan nor its principal active metabolite exhibits any partial agonist activity at the AT receptor, and both have much greater affinity (about 1000-fold) for the AT receptor than for the AT receptor. binding studies indicate that losartan is a reversible, competitive inhibitor of the AT receptor. The active metabolite is 10 to 40 times more potent by weight than losartan and appears to be a reversible, non-competitive inhibitor of the AT receptor.

Neither losartan nor its active metabolite inhibits ACE (kininase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin), nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Non-Clinical Toxicology

Losartan potassium is contraindicated:

When pregnancy is detected, discontinue Losartan potassium as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus [see ].

When given concurrently the following drugs may interact with thiazide diuretics.

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan potassium as soon as possible

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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