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TechneLite

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Overview

What is TechneLite?

DESCRIPTION:

Lantheus Medical Imaging, Inc. TECHNELITE, Technetium Tc 99m Generator consists of a column containing fission produced Molybdenum Mo99 adsorbed on alumina. The terminally sterilized and sealed column is enclosed in a lead shield; the shield and other components are sealed in a cylindrical plastic container with an attached handle. Built into the top surface are two recessed wells marked SALINE CHARGE and COLLECT. Needles protruding from these two wells accommodate supplied sterile eluant charge vials and sterile eluate collection vials. The eluting solvent consists of Sodium Chloride 0.9%, prepacked into septum-sealed vials.

The eluate collection vial is evacuated, sterile and non-pyrogenic. A sterile 0.22 micrometer bacteriological filter is incorporated between the column outlet and the collection vials. During and subsequent to elution, the eluate collection vial should be kept in a radiation shield. The Generator is shipped with a silicone needle seal over the charge needle and a vented needle cover over the collect needle. A sterile vial containing bacteriostat is supplied for the customer to aseptically reseal the collect needle after each elution.



What does TechneLite look like?



What are the available doses of TechneLite?

Sorry No records found.

What should I talk to my health care provider before I take TechneLite?

Sorry No records found

How should I use TechneLite?

The Technelite generator is a source of sodium pertechnetate Tc 99m for use in the preparation of FDA-approved diagnostic radiopharmaceuticals, as described in the labeling of these diagnostic radiopharmaceutical kits.

Sodium Pertechnetate Tc 99m Injection is used IN ADULTS as an agent for:

Sodium Pertechnetate Tc 99m Injection is used IN CHILDREN as an agent for:

DOSAGE AND ADMINISTRATION:

The suggested dose range employed for various diagnostic indications in the average ADULT PATIENT (70kg) is:

The recommended dosage range in PEDIATRIC PATIENTS is:

The patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration of the dose.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. The solution to be administered as the patient dose should be clear and contain no particulate matter. Do not use an eluate of the TECHNELITE, Technetium Tc 99m Generator later than one (1) working day after elution (12 hours).


What interacts with TechneLite?

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What are the warnings of TechneLite?

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What are the precautions of TechneLite?

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What are the side effects of TechneLite?

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What should I look out for while using TechneLite?

CONTRAINDICATIONS:

WARNINGS:

Long-term cumulative radiation exposure may be associated with an increased risk of cancer.


What might happen if I take too much TechneLite?

Sorry No Records found


How should I store and handle TechneLite?

Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Pharmacist: Dispense in a tight, light-resistant container with a child-resistant closure and medication guide. Store at 25°C (77°F); excursions permitted to 15 to 30°C (59 to 86°F) [see USP Controlled Room Temperature]. Pharmacist: Dispense in a tight, light-resistant container with a child-resistant closure and medication guide. HOW SUPPLIED:Each generator is supplied with the following standard components:First order generators are shipped with the following accessory components:Extra quantities of these components may be obtained at the customer's request.HOW SUPPLIED:Each generator is supplied with the following standard components:First order generators are shipped with the following accessory components:Extra quantities of these components may be obtained at the customer's request.HOW SUPPLIED:Each generator is supplied with the following standard components:First order generators are shipped with the following accessory components:Extra quantities of these components may be obtained at the customer's request.HOW SUPPLIED:Each generator is supplied with the following standard components:First order generators are shipped with the following accessory components:Extra quantities of these components may be obtained at the customer's request.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

CLINICAL PHARMACOLOGY:

After intravascular administration the pertechnetate ion gradually equilibrates with the extracellular space. A fraction is promptly excreted via the kidneys.

Following the administration of Sodium Pertechnetate Tc 99m Injection as an eye drop, the drug mixes with tears within the conjunctival space. Within seconds to minutes it leaves the conjunctival space and escapes into the inferior meatus of the nose through the nasolacrimal drainage system. During this process the pertechnetate ion passes through the canaliculi, the lacrimal sac and the nasolacrimal duct. In the event of any anatomical or functional blockage of the drainage system there will be a backflow resulting in tearing (epiphora). Thus the pertechnetate escapes the conjunctival space in the tears.

While the major part of the pertechnetate escapes within a few minutes of normal drainage and tearing, it has been documented that there is some degree of transconjunctival absorption with a fractional turnover rate of 0.015/min in normal individuals, 0.021/min in patients without any sac and 0.027/min in patients with inflamed conjunctiva due to chronic dacryocystitis. Individual values may vary but these rates are probably representative and indicate that the maximum possible pertechnetate absorbed will remain below one thousandth of that used in other routine diagnostic procedures.

Non-Clinical Toxicology
CONTRAINDICATIONS:

WARNINGS:

Long-term cumulative radiation exposure may be associated with an increased risk of cancer.

The sedative effects of metaxalone tablets and other CNS depressants (e.g., alcohol, benzodiazepines, opiods, trycyclic antidepressants) may be additive. Therefore, caution should be exercised with patients who take more than one of these CNS depressants simultaneoulsy.

Due to the potential for SS, caution is advised when metaxalone is co-administered with drugs that may affect the serotonergic neurotransmitter systems, such as tramadol or SSRIs (see ).

As in the use of any radioactive material, care should be taken to minimize radiation exposure to the patient consistent with proper patient management and to ensure minimum radiation exposure to occupational workers.

Since the eluate does not contain an antimicrobial agent, it should not be used after 12 hours from the time of TECHNELITE, Technetium Tc 99m Generator elution.

After the termination of the nasolacrimal imaging procedure, blowing the nose and washing the eyes with sterile distilled water or an isotonic sodium chloride solution will further minimize the radiation dose.

Radiopharmaceuticals should be used only by physicians who are qualified by training and experience in the safe handling of radionuclides and whose experience and training have been approved by the appropriate government agency authorized to license the use of radionuclides.

ADVERSE REACTIONS:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Interactions

Interactions

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