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GONITRO

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Overview

What is GONITRO?

Nitroglycerin, an organic nitrate, is a vasodilator which has effects on both arteries and veins. The chemical name for nitroglycerin is 1,2,3-propanetriol trinitrate (CHNO). The compound has a molecular weight of 227.09. The chemical structure is:

GONITRO is a powder containing nitroglycerin. Each packet of GONITRO delivers 400 mcg of nitroglycerin when administered under the tongue. The sublingual powder is formulated with the following inactive ingredients: anhydrous dibasic calcium phosphate, isomalt, medium-chain triglycerides, peppermint oil, and oleoyl polyoxylglycerides.



What does GONITRO look like?



What are the available doses of GONITRO?

GONITRO (nitroglycerin) sublingual powder, in packets containing 400 mcg of nitroglycerin.

What should I talk to my health care provider before I take GONITRO?

How should I use GONITRO?

GONITRO is indicated for acute relief of an attack or prophylaxis of angina pectoris due to coronary artery disease.

Administer one or two packets (400 mcg of nitroglycerin per packet) at the onset of an attack under the tongue. One additional packet may be administered every five minutes as needed. No more than three packets are recommended within a 15-minute period. If the chest pain persists  seek prompt medical attention. GONITRO may be used prophylactically 5 to 10 minutes prior to engaging in activities that might precipitate an acute attack. 


What interacts with GONITRO?

Sorry No Records found


What are the warnings of GONITRO?

Sorry No Records found


What are the precautions of GONITRO?

Sorry No Records found


What are the side effects of GONITRO?

Sorry No records found


What should I look out for while using GONITRO?

Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators. (, )

Severe anemia. ()

Increased intracranial pressure. ()

Hypersensitivity to GONITRO or to other nitrates or nitrites or any excipient. ()

Circulatory failure and shock. ()


What might happen if I take too much GONITRO?


How should I store and handle GONITRO?

Store at 20° to 25°C (68° to 77°F); see USP controlled room temperature. Protect from light. Do not freeze.Each box of GONITRO (nitroglycerin) sublingual powder, contains 12, 36 or 96 packets.Each packet contains 400 mcg of nitroglycerin.GONITRO is available as:• Box of 12 packets NDC 70007-400-12• Box of 36 packets NDC 70007-400-36• Box of 96 packets NDC 70007-400-96Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 5°C – 40°C (41°F – 104°F). Rx Only.Each box of GONITRO (nitroglycerin) sublingual powder, contains 12, 36 or 96 packets.Each packet contains 400 mcg of nitroglycerin.GONITRO is available as:• Box of 12 packets NDC 70007-400-12• Box of 36 packets NDC 70007-400-36• Box of 96 packets NDC 70007-400-96Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 5°C – 40°C (41°F – 104°F). Rx Only.Each box of GONITRO (nitroglycerin) sublingual powder, contains 12, 36 or 96 packets.Each packet contains 400 mcg of nitroglycerin.GONITRO is available as:• Box of 12 packets NDC 70007-400-12• Box of 36 packets NDC 70007-400-36• Box of 96 packets NDC 70007-400-96Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 5°C – 40°C (41°F – 104°F). Rx Only.Each box of GONITRO (nitroglycerin) sublingual powder, contains 12, 36 or 96 packets.Each packet contains 400 mcg of nitroglycerin.GONITRO is available as:• Box of 12 packets NDC 70007-400-12• Box of 36 packets NDC 70007-400-36• Box of 96 packets NDC 70007-400-96Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 5°C – 40°C (41°F – 104°F). Rx Only.Each box of GONITRO (nitroglycerin) sublingual powder, contains 12, 36 or 96 packets.Each packet contains 400 mcg of nitroglycerin.GONITRO is available as:• Box of 12 packets NDC 70007-400-12• Box of 36 packets NDC 70007-400-36• Box of 96 packets NDC 70007-400-96Store at 20°C - 25°C (68°F - 77°F); excursions permitted between 5°C – 40°C (41°F – 104°F). Rx Only.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Nitroglycerin forms free radical nitric oxide (NO), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilatation.

Non-Clinical Toxicology
Use of phosphodiesterase type 5 (PDE-5) inhibitors, such as avanafil, sildenafil, tadalafil, or vardenafil, or soluble guanylate cyclase (sGC) stimulators. (, )

Severe anemia. ()

Increased intracranial pressure. ()

Hypersensitivity to GONITRO or to other nitrates or nitrites or any excipient. ()

Circulatory failure and shock. ()

Excessive use may lead to the development of tolerance. Only the smallest number of doses required for effective relief of the acute angina attack should be used

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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