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Neulasta

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Overview

What is Neulasta?

Neulasta (pegfilgrastim) is a covalent conjugate of recombinant methionyl human G-CSF (filgrastim) and monomethoxypolyethylene glycol. Filgrastim is a water-soluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (kD). Filgrastim is obtained from the bacterial fermentation of a strain of transformed with a genetically engineered plasmid containing the human G-CSF gene. To produce pegfilgrastim, a 20 kD monomethoxypolyethylene glycol molecule is covalently bound to the N-terminal methionyl residue of filgrastim. The average molecular weight of pegfilgrastim is approximately 39 kD.

Neulasta is provided in two presentations:

The delivered 0.6 mL dose from either the prefilled syringe for manual subcutaneous injection or the OBI for Neulasta contains 6 mg pegfilgrastim (based on protein weight) in a sterile, clear, colorless, preservative-free solution (pH 4.0) containing acetate (0.35 mg), polysorbate 20 (0.02 mg), sodium (0.02 mg), and sorbitol (30 mg) in Water for Injection, USP.



What does Neulasta look like?



What are the available doses of Neulasta?

What should I talk to my health care provider before I take Neulasta?

How should I use Neulasta?

Neulasta is indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia   .

Limitations of Use

Neulasta is not indicated for the mobilization of peripheral blood progenitor cells for hematopoietic stem cell transplantation. 

The recommended dosage of Neulasta is a single subcutaneous injection of 6 mg administered once per chemotherapy cycle.  For dosing in pediatric patients weighing less than 45 kg, refer to Table 1. Do not administer Neulasta between 14 days before and 24 hours after administration of cytotoxic chemotherapy.  


What interacts with Neulasta?

Sorry No Records found


What are the warnings of Neulasta?

Sorry No Records found


What are the precautions of Neulasta?

Sorry No Records found


What are the side effects of Neulasta?

Sorry No records found


What should I look out for while using Neulasta?

Neulasta is contraindicated in patients with a history of serious allergic reactions to pegfilgrastim or filgrastim. Reactions have included anaphylaxis .


What might happen if I take too much Neulasta?

 Overdosage of Neulasta may result in leukocytosis and bone pain. Events of edema, dyspnea, and pleural effusion have been reported in a single patient who administered Neulasta on 8 consecutive days in error. In the event of overdose, the patient should be monitored for adverse reactions .


How should I store and handle Neulasta?

Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  Neulasta singledose prefilled syringe for manual use Neulasta is supplied in a prefilled single-dose syringe for manual use containing 6 mg pegfilgrastim, supplied with a 27-gauge, 1/2-inch needle with an UltraSafe Needle Guard.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Neulasta is provided in a dispensing pack containing one sterile 6 mg/0.6 mL prefilled syringe (NDC 55513-190-01).Neulasta prefilled syringe does not bear graduation marks and is intended only to deliver the entire contents of the syringe (6 mg/0.6 mL) for direct administration.  Use of the prefilled syringe is not recommended for direct administration for pediatric patients weighing less than 45 kg who require doses that are less than the full contents of the syringe.Store refrigerated between 36°F to 46°F (2°C to 8°C) in the carton to protect from light. Do not shake.  Discard syringes stored at room temperature for more than 48 hours.  Avoid freezing; if frozen, thaw in the refrigerator before administration. Discard syringe if frozen more than once.Neulasta Onpro kitNeulasta Onpro kit is provided in a carton containing one sterile prefilled syringe and one sterile on-body injector (OBI) for Neulasta (NDC 55513-192-01).The single-dose prefilled syringe contains 0.64 mL of solution that delivers 6 mg/0.6 mL of pegfilgrastim when used with the OBI for Neulasta.  The prefilled syringe is supplied with a 27-gauge, 1/2-inch needle.  The syringe does not bear graduation marks and is only to be used with the OBI for Neulasta.The needle cap of the prefilled syringe contains dry natural rubber (a derivative of latex).Store Neulasta Onpro kit in the refrigerator at 36°F to 46°F (2°C to 8°C) until ready for use. Because the OBI for Neulasta is at room temperature during the period of use, Neulasta Onpro kit should not be held at room temperature longer than 12 hours prior to use. Discard Neulasta Onpro kit if stored at room temperature for more than 12 hours. Do not use the OBI for Neulasta if its packaging has been previously opened.  


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Pegfilgrastim is a colony-stimulating factor that acts on hematopoietic cells by binding to specific cell surface receptors, thereby stimulating proliferation, differentiation, commitment, and end cell functional activation.

Non-Clinical Toxicology
Neulasta is contraindicated in patients with a history of serious allergic reactions to pegfilgrastim or filgrastim. Reactions have included anaphylaxis .

Splenic rupture, including fatal cases, can occur following the administration of Neulasta.  Evaluate for an enlarged spleen or splenic rupture in patients who report left upper abdominal or shoulder pain after receiving Neulasta.

The following serious adverse reactions are discussed in greater detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).