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Cubicin

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Overview

What is Cubicin?

CUBICIN (daptomycin for injection) contains daptomycin, a cyclic lipopeptide antibacterial agent derived from the fermentation of . The chemical name is -decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl--3-methyl-L-glutamyl-3-anthraniloyl-L-alanine ε-lactone. The chemical structure is:

The empirical formula is CHNO; the molecular weight is 1620.67. CUBICIN is supplied in a single-dose vial as a sterile, preservative-free, pale yellow to light brown, lyophilized cake containing approximately 500 mg of daptomycin for intravenous (IV) use following reconstitution with 0.9% sodium chloride injection The only inactive ingredient is sodium hydroxide, which is used for pH adjustment. Freshly reconstituted solutions of CUBICIN range in color from pale yellow to light brown.



What does Cubicin look like?



What are the available doses of Cubicin?

For Injection: 500 mg lyophilized powder for reconstitution in a single-dose vial ()

What should I talk to my health care provider before I take Cubicin?

How should I use Cubicin?

CUBICIN is indicated for the treatment of adult and pediatric patients (1 to 17 years of age) with complicated skin and skin structure infections (cSSSI) caused by susceptible isolates of the following Gram-positive bacteria: (including methicillin-resistant isolates), subsp. and (vancomycin-susceptible isolates only).

Administer to intravenously in 0.9% sodium chloride, either by injection over a 2-minute period or by infusion over a 30-minute period. (, )

Recommended dosage regimen for adult patients (, , ):


What interacts with Cubicin?

Sorry No Records found


What are the warnings of Cubicin?

Sorry No Records found


What are the precautions of Cubicin?

Sorry No Records found


What are the side effects of Cubicin?

Sorry No records found


What should I look out for while using Cubicin?

CUBICIN is contraindicated in patients with known hypersensitivity to daptomycin.


What might happen if I take too much Cubicin?

In the event of overdosage, supportive care is advised with maintenance of glomerular filtration. Daptomycin is cleared slowly from the body by hemodialysis (approximately 15% of the administered dose is removed over 4 hours) and by peritoneal dialysis (approximately 11% of the administered dose is removed over 48 hours). The use of high-flux dialysis membranes during 4 hours of hemodialysis may increase the percentage of dose removed compared with that removed by low-flux membranes.


How should I store and handle Cubicin?

CUBICIN (daptomycin for injection) is supplied as a sterile pale yellow to light brown lyophilized cake in a single-dose 10 mL vial containing 500 mg of daptomycin: Package of 1 (NDC 67919-011-01).


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Daptomycin is an antibacterial drug

Non-Clinical Toxicology
CUBICIN is contraindicated in patients with known hypersensitivity to daptomycin.

Anaphylaxis/hypersensitivity reactions have been reported with the use of antibacterial agents, including CUBICIN, and may be life-threatening. If an allergic reaction to CUBICIN occurs, discontinue the drug and institute appropriate therapy

The following adverse reactions are described, or described in greater detail, in other sections:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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