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Silenor

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Overview

What is Silenor?

Silenor (doxepin) is available in 3 mg and 6 mg strength tablets for oral administration. Each tablet contains 3.39 mg or 6.78 mg doxepin hydrochloride, equivalent to 3 mg and 6mg of doxepin, respectively.

Chemically, doxepin hydrochloride is an (E) and (Z) geometric, isomeric mixture of 1 propanamine, 3-dibenz[]oxepin-11(6)ylidene--dimethyl-hydrochloride. It has the following structure:

Doxepin hydrochloride is a white crystalline powder, with a slight amine-like odor, that is readily soluble in water. It has a molecular weight of 315.84 and molecular formula of C H NO•HCl.

Each Silenor tablet includes the following inactive ingredients: microcrystalline cellulose, colloidal silicon dioxide, and magnesium stearate. The 3 mg tablet also contains FD&C Blue No.1. The 6 mg tablet also contains D&C Yellow No. 10 and FD&C Blue No. 1.



What does Silenor look like?



What are the available doses of Silenor?

Silenor is an immediate-release, oval-shaped, tablet for oral administration available in strengths of 3 mg and 6 mg. The tablets are blue (3 mg) or green (6 mg) and are debossed with 3 or 6, respectively, on one side and SP on the other. Silenor tablets are scored.

What should I talk to my health care provider before I take Silenor?

How should I use Silenor?

Silenor is indicated for the treatment of insomnia characterized by difficulty with sleep maintenance. The clinical trials performed in support of efficacy were up to 3 months in duration []

The dose of Silenor should be individualized.


What interacts with Silenor?

Sorry No Records found


What are the warnings of Silenor?

Sorry No Records found


What are the precautions of Silenor?

Sorry No Records found


What are the side effects of Silenor?

Sorry No records found


What should I look out for while using Silenor?

Hypersensitivity to doxepin hydrochloride, inactive ingredients, or other dibenzoxepines. ()

Co-administration with Monoamine Oxidase Inhibitors (MAOIs): Do not administer if patient is taking MAOIs or has used MAOIs within the past two weeks. ()

Untreated narrow angle glaucoma or severe urinary retention. ()


What might happen if I take too much Silenor?

Doxepin is routinely administered for indications other than insomnia at doses 10- to 50-fold higher than the highest recommended dose of Silenor.

The signs and symptoms associated with doxepin use at doses several-fold higher than the maximum recommended dose (Excessive dose) of Silenor for the treatment of insomnia are described , as are signs and symptoms associated with higher multiples of the maximum recommended dose (Critical overdose) .


How should I store and handle Silenor?

Store at controlled room temperature 20° - 25°C (68° - 77°F), protected from light.Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316Acyclovir Tablets, USP 400 mg are available for oral administration as white to off-white, oval, unscored tablets imprinted "Apotex Logo 5306" on one side and plain on the other side. They are supplied as follows: Available in Unit Dose Box of 100 Tablets (NDC 0904-5790-61) Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature] and protect from moisture.APOTEX INC.ACYCLOVIR TABLETS, USP400 MG & 800 MGRevised: February 2016Rev. 3 LHC50140316


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Doxepin binds with high affinity to the histamine H receptor (Ki < 1 nM) where it functions as an antagonist. The exact mechanism by which doxepin exerts its sleep maintenance effect is unknown but is believed due to its antagonism of the H receptor.

Non-Clinical Toxicology
Hypersensitivity to doxepin hydrochloride, inactive ingredients, or other dibenzoxepines. ()

Co-administration with Monoamine Oxidase Inhibitors (MAOIs): Do not administer if patient is taking MAOIs or has used MAOIs within the past two weeks. ()

Untreated narrow angle glaucoma or severe urinary retention. ()

See .

Because sleep disturbances may be the presenting manifestation of a physical and/or psychiatric disorder, symptomatic treatment of insomnia should be initiated only after careful evaluation of the patient. Exacerbation of insomnia or the emergence of new cognitive or behavioral abnormalities may be the consequence of an unrecognized psychiatric or physical disorder. Such findings have emerged during the course of treatment with hypnotic drugs.

The following serious adverse reactions are discussed in greater detail in other sections of labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).