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Sodium Pyruvate, Inosine, Adenine, Sodium Phosphate, Dibasic, and Sodium Phosphate, Monobasic, Monohydrate
Overview
What is Rejuvesol?
Rejuvesol
rejuvesol
rejuvesol
What does Rejuvesol look like?
What are the available doses of Rejuvesol?
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What should I talk to my health care provider before I take Rejuvesol?
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How should I use Rejuvesol?
Rejuvesol
NOTE:
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5,6
Warning and Contraindications
What interacts with Rejuvesol?
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What are the warnings of Rejuvesol?
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What are the precautions of Rejuvesol?
- Aseptic technique must be maintained at all times.
- Do not use unless solution is clear/colorless and seal is intact. Product that exhibits a slight yellow color should not be used. Product instability has been observed after continuous exposure at high temperature (after 6 months at 40 °C and after 9 months at >30 °C).
- This product contains no bacteriostatic or antimicrobial agents and is intended for single use only.
- Rx Only - Federal (USA) law prohibits dispensing without prescription.
Array
What are the side effects of Rejuvesol?
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What should I look out for while using Rejuvesol?
Rejuvesol
Rejuvesol
RBC rejuvenated before 6 days of storage may achieve 2,3-DPG levels in excess of 2 times normal and ATP levels in excess of 1.5 times normal.
In patients with reduced arterial blood p0
of less than 40 torr, the use of RBC rejuvenated before 6 days of storage are contraindicated because their high 2,3-DPG levels and low oxygen affinity may impair proper oxygenation of the red blood cells in the lung.
Rejuvenated RBC are further processed prior to transfusion to remove the un-used portion of
Solution, by-products of the rejuvenation process, and any other potential storage-related impurities in
Solution. Based on the concentration of the residual inosine in rejuvenated RBC that are either washed or deglycerolized, the average washout of inosine was calculated to be > 97.4%. A literature search for potential toxicity associated with the ingredients that comprise
Solution, including potential metabolites, was conducted.
This report concludes that no theoretical contraindications would be associated with the transfusion of a single unit of
, rejuvenated RBC that would contain amounts of pyruvate, inosine, adenine, phosphate, hypoxanthine, uric acid, and lactate that exceed reference values (excluding lactate) as these substances are naturally metabolized and/or are excreted.
The maximum number of properly processed rejuvenated RBC that can be transfused to a single recipient over their entire lifetime has not been determined.
What might happen if I take too much Rejuvesol?
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How should I store and handle Rejuvesol?
Storage and HandlingStore at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) (see USP Controlled Room Temperature).See Storage and HandlingStore at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) (see USP Controlled Room Temperature).See Storage and HandlingStore at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) (see USP Controlled Room Temperature).See PN 7012: 50 mL vial; 12 vials per case
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
A gradual depletion of red blood cell adenosine triphosphate (ATP) and 2,3 diphosphoglycerate (2,3-DPG) occurs with storage of RBC at 1-6 °C.
The level of 2,3-DPG in RBC stored for greater than 14 days is less than 10% of normal
. Rejuvenation of RBC with
Solution increases the levels of ATP and 2,3-DPG.
An in vitro loss of red blood cells occurs with the preservation and processing of RBC. Thus, the effectiveness of a transfusion is influenced by both the total number of red blood cells transfused and the number of those cells which remain in circulation. Therefore, the "dose" of a transfusion is defined as the percentage of pre-transfusion recovered red blood cells multiplied by the 24 hour post-transfusion survival value.
Rejuvenation is accomplished by incubating the contents of one 50 mL vial of
Solution with one unit of RBC (prepared from up to 550 mL of whole blood) for sixty (60) minutes at 37 °C. Citra recommends that the entire 50 mL of
Solution be added to a "smaller than normal" RBC as long as the prerejuvenation net packed cell weight is greater than 110 grams.
Non-Clinical Toxicology
RejuvesolRejuvesol
RBC rejuvenated before 6 days of storage may achieve 2,3-DPG levels in excess of 2 times normal and ATP levels in excess of 1.5 times normal. In patients with reduced arterial blood p0 of less than 40 torr, the use of RBC rejuvenated before 6 days of storage are contraindicated because their high 2,3-DPG levels and low oxygen affinity may impair proper oxygenation of the red blood cells in the lung.
Rejuvenated RBC are further processed prior to transfusion to remove the un-used portion of Solution, by-products of the rejuvenation process, and any other potential storage-related impurities in Solution. Based on the concentration of the residual inosine in rejuvenated RBC that are either washed or deglycerolized, the average washout of inosine was calculated to be > 97.4%. A literature search for potential toxicity associated with the ingredients that comprise Solution, including potential metabolites, was conducted. This report concludes that no theoretical contraindications would be associated with the transfusion of a single unit of , rejuvenated RBC that would contain amounts of pyruvate, inosine, adenine, phosphate, hypoxanthine, uric acid, and lactate that exceed reference values (excluding lactate) as these substances are naturally metabolized and/or are excreted.
The maximum number of properly processed rejuvenated RBC that can be transfused to a single recipient over their entire lifetime has not been determined.
Reversible decreases in steady-state plasma digoxin concentrations and renal glycoside excretion were observed in patients receiving beta-acetyldigoxin and chemotherapy regimens containing cyclophosphamide, vincristine and prednisone with or without cytarabine or procarbazine. Steady-state plasma digitoxin concentrations did not appear to change. Therefore, monitoring of plasma digoxin levels may be indicated in patients receiving similar combination chemotherapy regimens. The utilization of digitoxin for such patients may be considered as an alternative.
An interaction study between gentamicin and cytarabine showed a cytarabine related antagonism for the susceptibility of strains. This study suggests that in patients on cytarabine being treated with gentamicin for a infection, the lack of a prompt therapeutic response may indicate the need for reevaluation of antibacterial therapy.
Clinical evidence in one patient showed possible inhibition of fluorocytosine efficacy during therapy with cytarabine. This may be due to potential competitive inhibition of its uptake.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
Interactions
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