Disclaimer:
Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.
PRAZIQUANTEL
Overview
What is PRAZIQUANTEL?
Praziquantel is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.
Praziquantel is 2-(cyclohexylcarbonyl)-1,2,3,6,7, 11b-hexahydro-4H-pyrazino [2, 1-a] isoquinolin-4-one with the molecular formula; CHNO. The structural formula is as follows:
Praziquantel is a white to nearly white crystalline powder of bitter taste. The compound is stable under normal conditions and melts at 136°C to 140°C with decomposition. The active substance is hygroscopic. Praziquantel is easily soluble in chloroform and dimethylsulfoxide, soluble in ethanol and very slightly soluble in water.
Praziquantel tablets, USP contain 600 mg of praziquantel. Inactive ingredients: corn starch, croscarmellose sodium, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, polyethylene glycol, titanium dioxide and hypromellose.
What does PRAZIQUANTEL look like?
What are the available doses of PRAZIQUANTEL?
Sorry No records found.
What should I talk to my health care provider before I take PRAZIQUANTEL?
Sorry No records found
How should I use PRAZIQUANTEL?
Praziquantel Tablets, USP 600 mg are indicated for the treatment of infections due to: all species of schistosoma (for example, and and infections due to the liver flukes, (approval of this indication was based on studies in which the two species were not differentiated).
The dosage recommended for the treatment of schistosomiasis is: 20 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The recommended dose for clonorchiasis and opisthorchiasis is: 25 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The tablets should be washed down unchewed with water during meals. Keeping the tablets or segments thereof in the mouth can reveal a bitter taste which can promote gagging or vomiting.
What interacts with PRAZIQUANTEL?
Sorry No Records found
What are the warnings of PRAZIQUANTEL?
Sorry No Records found
What are the precautions of PRAZIQUANTEL?
Sorry No Records found
What are the side effects of PRAZIQUANTEL?
Sorry No records found
What should I look out for while using PRAZIQUANTEL?
Praziquantel is contraindicated in patients who previously have shown hypersensitivity to the drug or any of the excipients. Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound.
Concomitant administration with strong Cytochrome P450 (P450) inducers, such as rifampin, is contraindicated since therapeutically effective blood levels of praziquantel may not be achieved
In patients receiving rifampin who need immediate treatment for schistosomiasis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment
.
Therapeutically effective levels of praziquantel may not be achieved when administered concomitantly with strong P450 inducers, such as rifampin
What might happen if I take too much PRAZIQUANTEL?
No data are available in humans.
How should I store and handle PRAZIQUANTEL?
Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Contains no preservatives. Store in original carton at 20°C to 25°C (68° F to 77° F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Do not freeze. Syringe StabilityIntravenous Admixture Stability:Do not dilute to concentrations below 1 mg/mL. Do not mix Venofer with other medications or add to parenteral nutrition solutions for intravenous infusion. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to infusion. Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017Praziquantel Tablets, USP is supplied as a 600 mg white to off white, film-coated, oblong tablets with three scores coded with "PAR" on one side "231" on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight. Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end. Praziquantel Tablets, USP 600 mg are available in bottles of 6 tablets (NDC49884-231-83).Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° and 30°C (59° and 86°F) [see USP Controlled Room Temperature]. Dist. by: Par PharmaceuticalChestnut Ridge, NY 10977 U.S.A.Mfg. by:Par Formulations Private Limited,9/215, Pudupakkam,Kelambakkam-603 103.Made in IndiaMfg. Lic. No.: TN00002121OS231-01-74-01Issued: 09/2017
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument.
After oral administration praziquantel is rapidly absorbed (80%), subjected to a first pass effect, metabolized and eliminated by the kidneys. Maximal serum concentration is achieved 1 to 3 hours after dosing. The half-life of praziquantel in serum is 0.8 to 1.5 hours.
Non-Clinical Toxicology
Praziquantel is contraindicated in patients who previously have shown hypersensitivity to the drug or any of the excipients. Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound.Concomitant administration with strong Cytochrome P450 (P450) inducers, such as rifampin, is contraindicated since therapeutically effective blood levels of praziquantel may not be achieved In patients receiving rifampin who need immediate treatment for schistosomiasis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment .
Therapeutically effective levels of praziquantel may not be achieved when administered concomitantly with strong P450 inducers, such as rifampin
ACE-inhibitors
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
Aspirin
When ibuprofen tablets are administered with aspirin, its protein binding is reduced, although the clearance of free ibuprofen tablets is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of ibuprofen and aspirin is not generally recommended because of the potential for increased adverse effects.
Diuretics
Clinical studies, as well as post marketing observations, have shown that ibuprofen tablets can reduce the natriuretic effect-of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see ), as well as to assure diuretic efficacy.
Lithium
Ibuprofen produced an elevation of plasma lithium levels and a reduction in renal lithium clearance in a study of eleven normal volunteers. The mean minimum lithium concentration increased 15% and the renal clearance of lithium was decreased by 19% during this period of concomitant drug administration. This effect has been attributed to inhibition of renal prostaglandin synthesis by ibuprofen. Thus, when ibuprofen and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity. (Read circulars for lithium preparation before use of such concurrent therapy.)
Methotrexate
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
Warfarin-type anticoagulants
Several short-term controlled studies failed to show that ibuprofen tablets significantly affected prothrombin times or a variety of other clotting factors when administered to individuals on coumarin-type anticoagulants. However, because bleeding has been reported when ibuprofen tablets and other NSAIDs have been administered to patients on coumarin-type anticoagulants, the physician should be cautious when administering ibuprofen tablets to patients on anticoagulants. The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that the users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
H-2 Antagonists
In studies with human volunteers, co-administration of cimetidine or ranitidine with ibuprofen had no substantive effect on ibuprofen serum concentrations.
Approximately 80% of a dose of praziquantel is excreted in the kidneys, almost exclusively (>99%) in the form of metabolites. Excretion might be delayed in patients with impaired renal function, but accumulation of unchanged drug would not be expected. Therefore, dose adjustment for renal impairment is not considered necessary. Nephrotoxic effects of praziquantel or its metabolites are not known.
Caution should be exercised in the administration of the usual recommended dose of praziquantel to hepatosplenic schistosomiasis patients with moderate to severe liver impairment (Child-Pugh class B and C). Reduced metabolism of praziquantel by the liver in these patients may lead to considerably higher and longer lasting plasma concentrations of unmetabolized praziquantel .
Minimal increases in liver enzymes have been reported in some patients.
Patients suffering from cardiac irregularities should be monitored during treatment.
As praziquantel can exacerbate central nervous system pathology due to schistosomiasis, as a general rule this drug should not be administered to individuals reporting a history of epilepsy and/or other signs of potential central nervous systems involvement such as subcutaneous nodules suggestive of cysticercosis.
When schistosomiasis or fluke infection is found to be associated with cerebral cysticercosis it is advised to hospitalize the patient for the duration of treatment.
Published data have shown a potential lack of efficacy of praziquantel against migrating schistosomulae. Data from two observational cohort studies in patients indicate that treatment with praziquantel in the acute phase of infection may not prevent progression from asymptomatic infection to acute schistosomiasis or from asymptomatic infection/ acute schistosomiasis into chronic phase.
In addition, the use of praziquantel in patients with schistosomiasis may be associated with clinical deterioration (paradoxical reactions, serum sickness Jarisch-Herxheimer like reactions: sudden inflammatory immune response suspected to be caused by the release of schistosomal antigens). These reactions predominantly occur in patients treated during the acute phase of schistosomiasis. They may lead to potentially life-threatening events, for example, respiratory failure, encephalopathy, and/or cerebral vasculitis.
The following side effects were observed generally in order of severity: malaise, headache, dizziness, abdominal discomfort with or without nausea, rise in temperature and urticaria. Such side effects may be more frequent and/or serious in patients with a heavy worm burden.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
Review
Read user comments about the side effects, benefits, and effectiveness of losartan oral.
Overall User Ratings
516Total User Reviews
User Reviews
Learn about
User Reviews
Professional
Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
Tips
Interactions
Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).