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CANCIDAS

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Overview

What is CANCIDAS?

CANCIDAS is a sterile, lyophilized product for intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of CANCIDAS is an echinocandin antifungal that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall.

CANCIDAS (caspofungin acetate) is 1-[(4,5)-5-[(2-aminoethyl)amino]--(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3)-3-hydroxy-L-ornithine] pneumocandin B diacetate (salt). CANCIDAS 50 mg contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate. CANCIDAS 50 mg also contains: 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. CANCIDAS 70 mg contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate. CANCIDAS 70 mg also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is CHNO∙2CHOand the formula weight is 1213.42. The structural formula is:



What does CANCIDAS look like?



What are the available doses of CANCIDAS?

CANCIDAS 50 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with a red aluminum band and a plastic cap. CANCIDAS 50-mg vial contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate.

CANCIDAS 70 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with a yellow/orange aluminum band and a plastic cap. CANCIDAS 70-mg vial contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate.

What should I talk to my health care provider before I take CANCIDAS?

How should I use CANCIDAS?

CANCIDAS is indicated as empirical therapy for presumed fungal infections in febrile, neutropenic adult and pediatric patients (3 months of age and older)

Administer CANCIDAS by slow intravenous (IV) infusion over approximately 1 hour. Do not administer CANCIDAS by IV bolus administration.


What interacts with CANCIDAS?

Sorry No Records found


What are the warnings of CANCIDAS?

Sorry No Records found


What are the precautions of CANCIDAS?

Sorry No Records found


What are the side effects of CANCIDAS?

Sorry No records found


What should I look out for while using CANCIDAS?

CANCIDAS is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product .


What might happen if I take too much CANCIDAS?

In 6 healthy subjects who received a single 210-mg dose, no significant adverse reactions were reported. Multiple doses above 150 mg daily have not been studied. Caspofungin is not dialyzable.

In clinical trials, one pediatric patient (16 years of age) unintentionally received a single dose of caspofungin of 113 mg (on Day 1), followed by 80 mg daily for an additional 7 days. No clinically significant adverse reactions were reported.


How should I store and handle CANCIDAS?

Storage and HandlingThe lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Storage and HandlingThe lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Metformin Hydrochloride Tablets USP 1000 mg, are available as white to off-white film-coated oval-shaped tablets, scored on two sides, debossed with “9” on the left side of the score and “3” on the right side of the score on one side and “72” on the left side of the score and “14” on the right side of the score on the other side. They are available in bottles of 30, 60, 90, 120, 180 and 270.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Caspofungin is an echinocandin antifungal drug

Non-Clinical Toxicology
CANCIDAS is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product .







Furosemide

Nifedipine

Drugs that reduce metformin clearance

In healthy volunteers, the pharmacokinetics of metformin and propranolol, and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.

Metformin is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid, as compared to the sulfonylureas, which are extensively bound to serum proteins.

Other

Carbonic anhydrase inhibitors

Alcohol

Anaphylaxis and other hypersensitivity reactions have been reported during administration of CANCIDAS.

Possible histamine-mediated adverse reactions, including rash, facial swelling, angioedema, pruritus, sensation of warmth or bronchospasm have been reported.

Cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), some with a fatal outcome, have been reported with use of CANCIDAS .

Discontinue CANCIDAS at the first sign or symptom of a hypersensitivity reaction and administer appropriate treatment.

The following serious adverse reactions are discussed in detail in another section of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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