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KEVZARA

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Overview

What is KEVZARA?

Sarilumab is a human recombinant monoclonal antibody of the IgG1 subclass that binds to the IL-6 receptor and has an approximate molecular weight of 150 kDa. Sarilumab is produced by recombinant DNA technology in Chinese Hamster Ovary cell suspension culture.

KEVZARA (sarilumab) injection for subcutaneous administration is supplied as a sterile, colorless to pale yellow, preservative-free solution of approximately pH 6.0. KEVZARA is supplied in a single-dose pre-filled syringe or pre-filled pen. Each syringe or pen delivers 1.14 mL of solution containing 150 mg or 200 mg of sarilumab, arginine (8.94 mg), histidine (3.71 mg), polysorbate 20 (2.28 mg), sucrose (57 mg) and Water for Injection, USP.



What does KEVZARA look like?



What are the available doses of KEVZARA?

Injection: 150 mg/1.14 mL or 200 mg/1.14 mL solution in a single-dose pre-filled syringe ()

Injection: 150 mg/1.14 mL or 200 mg/1.14 mL solution in a single-dose pre-filled pen ()

What should I talk to my health care provider before I take KEVZARA?

How should I use KEVZARA?

KEVZARA is indicated for treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs).

KEVZARA may be used as monotherapy or in combination with methotrexate (MTX) or other conventional DMARDs.

The recommended dosage of KEVZARA is 200 mg once every two weeks given as a subcutaneous injection.

Reduce dose to 150 mg once every two weeks for management of neutropenia, thrombocytopenia and elevated liver enzymes


What interacts with KEVZARA?

Sorry No Records found


What are the warnings of KEVZARA?

Sorry No Records found


What are the precautions of KEVZARA?

Sorry No Records found


What are the side effects of KEVZARA?

Sorry No records found


What should I look out for while using KEVZARA?

KEVZARA is contraindicated in patients with known hypersensitivity to sarilumab or any of the inactive ingredients .

Patients treated with KEVZARA are at increased risk for developing serious infections that may lead to hospitalization or death Opportunistic infections have also been reported in patients receiving KEVZARA. Most patients who developed infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids.

Avoid use of KEVZARA in patients with an active infection.

Reported infections include:

Closely monitor patients for signs and symptoms of infection during treatment with KEVZARA. If a serious infection develops, interrupt KEVZARA until the infection is controlled.

Consider the risks and benefits of treatment with KEVZARA prior to initiating therapy in patients with chronic or recurrent infection.


What might happen if I take too much KEVZARA?

Sorry No Records found


How should I store and handle KEVZARA?

KEVZARA (sarilumab) injection is supplied as a colorless to pale yellow solution in a single-dose pre-filled syringes and single-dose pre-filled pens.