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GlucaGen

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Overview

What is GlucaGen?

GlucaGen (glucagon) for injection is an antihypoglycemic agent and a gastrointestinal motility inhibitor for subcutaneous, intramuscular or intravenous use. It is produced by expression of recombinant DNA in a vector with subsequent purification. The chemical structure of the glucagon in GlucaGen is identical to human glucagon and to glucagon extracted from beef and pork pancreas. Glucagon with the empirical formula of CHNOS, and a molecular weight of 3483, is a single-chain polypeptide containing 29 amino acid residues. The structure of glucagon is:

GlucaGen is a sterile, lyophilized white powder in a 2 mL vial (appearance of the powder may vary, and occasionally the powder may appear compacted). The reconstituted solution contains glucagon as hydrochloride 1 mg/mL and lactose monohydrate (107 mg). GlucaGen is supplied at pH 2.5-3.5 and is soluble in water.



What does GlucaGen look like?



What are the available doses of GlucaGen?

GlucaGen is supplied in a vial, alone, or accompanied by Sterile Water for Reconstitution (1 mL) also in a vial (10 pack or diagnostic kit). It is also supplied as GlucaGen HypoKit, a presentation with a disposable prefilled syringe containing 1 mL Sterile Water for Reconstitution. When the glucagon powder is reconstituted with Sterile Water for Reconstitution (if supplied) or with Sterile Water for Injection, USP, it forms a solution of 1 mg/mL glucagon for subcutaneous, intramuscular, or intravenous injection (appearance of the powder may vary, and occasionally the powder may appear compacted).

What should I talk to my health care provider before I take GlucaGen?

How should I use GlucaGen?

GlucaGen is used to treat severe hypoglycemic (low blood sugar) reactions which may occur in patients with diabetes mellitus treated with insulin. Because GlucaGen depletes glycogen stores, the patient should be given supplemental carbohydrates as soon as he/she awakens and is able to swallow, especially children or adolescents. Medical evaluation is recommended for all patients who experience severe hypoglycemia.

For GlucaGen HypoKit:


What interacts with GlucaGen?

Sorry No Records found


What are the warnings of GlucaGen?

Sorry No Records found


What are the precautions of GlucaGen?

Sorry No Records found


What are the side effects of GlucaGen?

Sorry No records found


What should I look out for while using GlucaGen?

GlucaGen is contraindicated in patients with:


What might happen if I take too much GlucaGen?

No reports of overdosage with GlucaGen have been reported. If overdosage occurs, the patient may experience nausea, vomiting, inhibition of GI tract motility, increase in blood pressure and pulse rate. In case of suspected overdosing, the serum potassium may decrease and should be monitored and corrected if needed. If the patient develops a dramatic increase in blood pressure, phentolamine mesylate has been shown to be effective in lowering blood pressure for the short time that control would be needed.


How should I store and handle GlucaGen?

Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature]. Divalproex sodiumextended-release tablets USP, 500mg are available as grey colored, oval shaped, beveled edge, biconvex coated tablets debossed “R” on one side and “534” on other side. Each divalproex sodium extended-release tablet contains divalproex sodiumequivalent to 500 mg of valproic acid and are supplied in bottles of 30’s, 60’s, 100’s and 500’s. Bottles of 30 NDC 55111-534-30 Bottles of 60 NDC 55111-534-60 Bottles of 100 NDC 55111-534-01 Bottles of 500 NDC 55111-534-05Recommended StorageStore tablets at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature].