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PURIXAN

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Overview

What is PURIXAN?

Mercaptopurine, a nucleoside metabolic inhibitor, known chemically as 1,7-dihydro-6H-purine-6-thione monohydrate, is an analogue of the purine bases adenine and hypoxanthine. Mercaptopurine is a yellow, odorless or practically odorless, crystalline powder with a molecular formula of CHNS•HO and a molecular weight of 170.20 as a monohydrate. The structural formula is:

PURIXAN (mercaptopurine) oral suspension is supplied for oral administration and contains 2000 mg/100 mL (20 mg/mL) of mercaptopurine. The suspension also contains the following inactive ingredients: xanthan gum, aspartame, concentrated raspberry juice, sucrose, ethyl parahydroxybenzoate sodium, methyl parahydroxybenzoate sodium, potassium sorbate, sodium hydroxide and purified water. PURIXAN is a pink to brown viscous suspension. In addition, a press-in bottle adapter and two oral dispensing syringes (one 1 mL and one 5 mL) are provided.



What does PURIXAN look like?



What are the available doses of PURIXAN?

Sorry No records found.

What should I talk to my health care provider before I take PURIXAN?

Sorry No records found

How should I use PURIXAN?

The recommended starting dose of PURIXAN in multi-agent combination chemotherapy maintenance regimens is 1.5 to 2.5 mg/kg (50 to 75 mg/m) as a single daily dose. After initiating PURIXAN, monitor complete blood counts (CBCs), transaminases, and bilirubin. Maintain ANC at a desirable level by reducing the dose in patients with excessive hematological toxicity. Evaluate the bone marrow in patients with prolonged or repeated marrow suppression to assess leukemia status and marrow cellularity. Evaluate thiopurine S-methyltransferase (TPMT) and nucleotide diphosphatase (NUDT15) status in patients with clinical or laboratory evidence of severe bone marrow toxicity, or repeated episodes of myelosuppression.


What interacts with PURIXAN?

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What are the warnings of PURIXAN?

Sorry No Records found


What are the precautions of PURIXAN?

Sorry No Records found


What are the side effects of PURIXAN?

Sorry No records found


What should I look out for while using PURIXAN?

Sorry No records found


What might happen if I take too much PURIXAN?

Signs and symptoms of mercaptopurine overdosage may be immediate (anorexia, nausea, vomiting, and diarrhea); or delayed (myelosuppression, liver dysfunction, and gastroenteritis). Dialysis cannot be expected to clear mercaptopurine. Hemodialysis is thought to be of marginal use due to the rapid intracellular incorporation of mercaptopurine into active metabolites with long persistence. The oral LD of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat. There is no known pharmacologic antagonist of mercaptopurine. PURIXAN should be discontinued immediately if unintended toxicity occurs during treatment. If a patient is seen immediately following an accidental overdosage of PURIXAN, it may be useful to induce emesis.


How should I store and handle PURIXAN?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Preserve in tight, light-resistant containers as defined in the USP.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Preserve in tight, light-resistant containers as defined in the USP.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.Cyclobenzaprine hydrochloride tablets USP are available in 5 mg and 10 mg dosage strengths. The 10 mg tablets are yellow colored, film coated, round, biconvex tablets debossed with ‘’ on one side and “” on other.Bottle of 10 - 68788-9295-0Bottle of 14 - 68788-9295-1Bottle of 15 - 68788-9295-5Bottle of 20 - 68788-9295-2Bottle of 30 - 68788-9295-3Bottle of 60 - 68788-9295-6Bottle of 90 - 68788-9295-9Bottle of 90 - 68788-9295-8STORAGEStore at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Rx Only Manufactured by:InvaGen Pharmaceuticals, Inc.Hauppauge, NY 11788Rev: 01/12Barcode:283-01-2012Repackaged by Preferred Pharmaceuticals, Inc.


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).