Fludarabine Phosphate

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Overview

What is Fludarabine Phosphate?

Fludarabine Phosphate Injection contains fludarabine phosphate, a nucleotide metabolic inhibitor. Fludarabine phosphate is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine (ara-A), that is relatively resistant to deamination by adenosine deaminase.

Each mL contains 25 mg of the active ingredient fludarabine phosphate, 1.78 mg disodium phosphate dihydrate, water for injection, qs; and sodium hydroxide to adjust pH to 7.5. The pH range for the final product is 7.3 to 7.7. Fludarabine Phosphate Injection is a sterile solution intended for intravenous administration.

The chemical name for fludarabine phosphate is 9H-Purin-6-amine, 2-fluoro-9-(5-0-phosphono-β-D-arabinofuranosyl)(2-fluoro-ara-AMP).

The molecular formula of fludarabine phosphate is CHFNOP (MW 365.2) and the structure is provided in Figure 1

Figure 1: Chemical Structure of Fludarabine Phosphate

What does Fludarabine Phosphate look like?

What are the available doses of Fludarabine Phosphate?

50 mg/2 mL (25 mg/mL)A clear, colorless or almost colorless, sterile solution intended for intravenous administration

What should I talk to my health care provider before I take Fludarabine Phosphate?

How should I use Fludarabine Phosphate?

Fludarabine Phosphate Injection is indicated for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen. The safety and effectiveness of Fludarabine Phosphate Injection in previously untreated or non-refractory patients with CLL have not been established.

The recommended adult dose of Fludarabine Phosphate Injection is 25 mg/m diluted in 100 to 125 cc of 5% dextrose injection USP or 0.9% sodium chloride USP administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Each 5-day course of treatment should commence every 28 days. Dosage may be decreased or delayed based on evidence of hematologic or nonhematologic toxicity. Physicians should consider delaying or discontinuing the drug if neurotoxicity occurs.

A number of clinical settings may predispose to increased toxicity from Fludarabine Phosphate Injection. These include advanced age, renal insufficiency, and bone marrow impairment. Such patients should be monitored closely for excessive toxicity and the dose modified accordingly.

The optimal duration of treatment has not been clearly established. It is recommended that three additional cycles of Fludarabine Phosphate Injection be administered following the achievement of a maximal response and then the drug should be discontinued.

What interacts with Fludarabine Phosphate?

Sorry No Records found

What are the warnings of Fludarabine Phosphate?

Sorry No Records found

What are the precautions of Fludarabine Phosphate?

Sorry No Records found

What are the side effects of Fludarabine Phosphate?

Sorry No records found

What should I look out for while using Fludarabine Phosphate?

None

What might happen if I take too much Fludarabine Phosphate?

High doses of fludarabine phosphate [] have been associated with an irreversible central nervous system toxicity characterized by delayed blindness, coma and death. High doses are also associated with severe thrombocytopenia and neutropenia due to bone marrow suppression. There is no known specific antidote for fludarabine phosphate overdosage. Treatment consists of drug discontinuation and supportive therapy.

How should I store and handle Fludarabine Phosphate?

Procedures for proper handling and disposal should be considered. Consideration should be given to handling and disposal according to guidelines issued for cytotoxic drugs. Several guidelines on this subject have been published. Caution should be exercised in the handling and preparation of Fludarabine Phosphate Injection solution. The use of latex gloves and safety glasses is recommended to avoid exposure in case of breakage of the vial or other accidental spillage. If the solution contacts the skin or mucous membranes, wash thoroughly with soap and water; rinse eyes thoroughly with plain water. Avoid exposure by inhalation or by direct contact of the skin or mucous membranes.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate and Amphetamine Sulfate Tablets5 mg: Blue, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and four partial bisects on the other side debossed with . Available in bottles of:7.5 mg: Blue, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:10 mg: Blue, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:12.5 mg: Peach, oval, biconvex tablet debossed with stylized over separated by a full score on one side and four partial bisects on the other side debossed with Available in bottles of:15 mg: Peach, round, flat-faced, beveled-edge tablet debossed with stylized over on one side and two partial bisects and a full score on the other side debossed with .Available in bottles of:20 mg: Peach, oval, flat-faced, beveled-edge tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with .Available in bottles of:30 mg: Peach, oval, biconvex tablet with two partial bisects on one side debossed with stylized over and two partial bisects and a full score on the other side debossed with . Available in bottles of:Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

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Clinical Information

Chemical Structure

No Image found

Clinical Pharmacology

Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.

Non-Clinical Toxicology

None

There are clear dose dependent toxic effects seen with fludarabine phosphate. Dose levels approximately 4 times greater (96 mg/m/day for 5 to 7 days) than that recommended for CLL (25 mg/m/day for 5 days) were associated with a syndrome characterized by delayed blindness, coma and death. Symptoms appeared from 21 to 60 days following the last dose. Thirteen of 36 patients (36%) who received fludarabine phosphate at high doses (96 mg/m/day for 5 to 7 days) developed this severe neurotoxicity. This syndrome has been reported rarely in patients treated with doses in the range of the recommended CLL dose of 25 mg/m/day for 5 days every 28 days. The effect of chronic administration of fludarabine phosphate on the central nervous system is unknown; however, patients have received the recommended dose for up to 15 courses of therapy.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

The most common adverse reactions include myelosuppression (neutropenia, thrombocytopenia and anemia), fever and chills, infection, and nausea and vomiting. Other commonly reported events include malaise, fatigue, anorexia, and weakness. Serious opportunistic infections have occurred in CLL patients treated with fludarabine phosphate. The most frequently reported adverse reactions and those reactions which are more clearly related to the drug are arranged below according to body system.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Review

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

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Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

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