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Trichophyton for Intradermal Skin Testing
Overview
What is Trichophyton for Intradermal Skin Testing?
Trichophyton
Trichophyton mentagrophytes
Trichophyton rubrum
WEIGHT BY VOLUME (W/V)
What does Trichophyton for Intradermal Skin Testing look like?
What are the available doses of Trichophyton for Intradermal Skin Testing?
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What should I talk to my health care provider before I take Trichophyton for Intradermal Skin Testing?
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How should I use Trichophyton for Intradermal Skin Testing?
Intradermal skin tests with extract are indicated for use in persons who are suspected of having Type I hypersensitivity (i.e. allergy) to the fungus.
Prior to administering skin tests, the skin should be cleaned with alcohol and allowed to dry completely. The tests should be placed on the volar surface of the forearm and four rows may be placed on the back.
The intradermal test is performed by administering 0.1 mL of extract into the skin. The injection should be given as superficially as possible creating a distinct bleb approximately 5 mm in diameter. The tests should be examined after 15 - 20 minutes and read as negative or positive. Test sites that show a wheal and flare response should be measured and reported in mm of edema and erythema or scored as 1+ to 4+ based on a mm reference scale. Induration after 24 - 48 hours can occur in some individuals and also may be recorded in mm.
What interacts with Trichophyton for Intradermal Skin Testing?
Conditions under which the administration of allergenic extract may be contraindicated, depending upon individual circumstances, include: EXTREME SENSITIVITY TO AN ALLERGEN - Determined from the allergic history, or from previous anaphylaxis following skin testing or subcutaneous injection; MYOCARDIAL INFARCTION - Patients who have experienced a recent myocardial infarction may be less able to tolerate the life-threatening effects of a serious adverse reaction. ASTHMA - Patients with highly unstable asthma are at greater risk of fatal reactions from skin tests than are patients without asthma, especially during seasonal exacerbations of the disease. Also, the combination of unstable asthma and treatment with B-adrenergic blockers appears to increase this risk. Allergenic extract should be temporarily withheld from patients if any of the following conditions exist: 1) severe symptoms of hay fever and/or asthma; 2) infection or flu accompanied by fever; and 3) exposure to excessive amounts of clinically relevant allergen(s) prior to skin testing.
What are the warnings of Trichophyton for Intradermal Skin Testing?
Patients who receive pamidronate disodium should have serum creatinine assessed prior to each treatment. Patients treated with pamidronate disodium for bone metastases should have the dose withheld if renal function has deteriorated (see
What are the precautions of Trichophyton for Intradermal Skin Testing?
GENERAL
PATIENT INFORMATION
DRUG INTERACTION
CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY
PREGNANCY CATEGORY C
NURSING MOTHERS
PEDIATRIC USE
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What are the side effects of Trichophyton for Intradermal Skin Testing?
LOCAL REACTIONS
SYSTEMIC REACTIONS
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What should I look out for while using Trichophyton for Intradermal Skin Testing?
Conditions under which the administration of allergenic extract may be contraindicated, depending upon individual circumstances, include: EXTREME SENSITIVITY TO AN ALLERGEN - Determined from the allergic history, or from previous anaphylaxis following skin testing or subcutaneous injection; MYOCARDIAL INFARCTION - Patients who have experienced a recent myocardial infarction may be less able to tolerate the life-threatening effects of a serious adverse reaction. ASTHMA - Patients with highly unstable asthma are at greater risk of fatal reactions from skin tests than are patients without asthma, especially during seasonal exacerbations of the disease. Also, the combination of unstable asthma and treatment with B-adrenergic blockers appears to increase this risk. Allergenic extract should be temporarily withheld from patients if any of the following conditions exist: 1) severe symptoms of hay fever and/or asthma; 2) infection or flu accompanied by fever; and 3) exposure to excessive amounts of clinically relevant allergen(s) prior to skin testing.
Physicians who use allergenic extracts should have a knowledge and practical understanding of allergy skin testing as described in the published literature.
Allergenic extracts are manufactured to assure high potency and therefore have the ability to cause serious local and systemic reactions, including death in highly sensitive patients. Patients should be informed of the risks of skin testing and instructed in the recognition of symptoms of an adverse allergic reaction (see PRECAUTIONS and ADVERSE REACTIONS below).
Excessively large local reactions or systemic reactions are more likely to occur if the patient is skin tested shortly after exposure to allergens to which he or she is sensitive.
What might happen if I take too much Trichophyton for Intradermal Skin Testing?
The signs and symptoms of overdosage are the same as those listed under ADVERSE REACTIONS, paragraphs 1 and 2.
The treatment of a systemic allergic reaction resulting from skin tests should include the following:
The above steps should be performed nearly simultaneously and as soon as possible after the reaction begins. Persistent wheezing may necessitate treatment with intravenous aminophylline and inhaled bronchodilators. For profound shock and hypotension, intravenous fluids, vasopressors and oxygen also may be needed. Maintenance of an open airway is critical if upper airway obstruction is present. Corticosteroids may provide benefit if symptoms are prolonged or recurrent.
How should I store and handle Trichophyton for Intradermal Skin Testing?
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .One mL of extract for intradermal skin testing is supplied in 2 mL sealed multidose vials. Each vial contains enough extract for 10 tests.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
In sensitive persons, allergenic extract elicits immediate-type skin reactions consisting of erythema and edema at the test site. This allergic inflammatory response is thought to begin with the reaction of allergen with immunoglobulin E (IgE) on the surface of the mast cell. This antigen-antibody reaction initiates a series of biochemical events that result in the release of histamine and other mediators from the mast cell. These mediators are responsible for the characteristic wheal and flare response associated with a positive skin test. The initial antigen-antibody reaction appears to be a specific response that is dependent upon the presence of allergen-specific IgE attached to the mast cell.
Delayed-type reactions occur in some individuals following the intradermal administration of extract. This response is due to the presence of sensitized lymphocytes. The reaction is characterized by erythema and induration that peaks between 24 and 48 hours after skin testing.
Non-Clinical Toxicology
Conditions under which the administration of allergenic extract may be contraindicated, depending upon individual circumstances, include: EXTREME SENSITIVITY TO AN ALLERGEN - Determined from the allergic history, or from previous anaphylaxis following skin testing or subcutaneous injection; MYOCARDIAL INFARCTION - Patients who have experienced a recent myocardial infarction may be less able to tolerate the life-threatening effects of a serious adverse reaction. ASTHMA - Patients with highly unstable asthma are at greater risk of fatal reactions from skin tests than are patients without asthma, especially during seasonal exacerbations of the disease. Also, the combination of unstable asthma and treatment with B-adrenergic blockers appears to increase this risk. Allergenic extract should be temporarily withheld from patients if any of the following conditions exist: 1) severe symptoms of hay fever and/or asthma; 2) infection or flu accompanied by fever; and 3) exposure to excessive amounts of clinically relevant allergen(s) prior to skin testing.Physicians who use allergenic extracts should have a knowledge and practical understanding of allergy skin testing as described in the published literature. Allergenic extracts are manufactured to assure high potency and therefore have the ability to cause serious local and systemic reactions, including death in highly sensitive patients. Patients should be informed of the risks of skin testing and instructed in the recognition of symptoms of an adverse allergic reaction (see PRECAUTIONS and ADVERSE REACTIONS below). Excessively large local reactions or systemic reactions are more likely to occur if the patient is skin tested shortly after exposure to allergens to which he or she is sensitive.
Drugs can interfere with the performance of skin tests.
Antihistamines: Response to mediator (histamine) released by allergens is suppressed by antihistamines. The length of suppression varies and is dependent on individual patient, type of antihistamine and length of time the patient has been on antihistamines. The duration of this suppression may be as little as 24 hours (chlorpheniramine), and can be as long as 40 days (astemizole).
Tricyclic Antidepressants: These exert a potent and sustained decrease of skin reactivity to histamine which may last for a few weeks.
Beta Agonists: Oral terbutaline and parenteral ephedrine, in general, have been shown to decrease allergen induced wheal.
Dopamine: Intravenous infusion of dopamine may inhibit skin test responses.
Beta Blocking Agents: Propranolol can significantly increase skin test reactivity.
Other Drugs: Short acting steroids, inhaled beta agonists, theophylline and cromolyn do not seem to affect skin test response.
GENERAL
PATIENT INFORMATION
DRUG INTERACTION
CARCINOGENESIS, MUTAGENESIS, IMPAIRMENT OF FERTILITY
PREGNANCY CATEGORY C
NURSING MOTHERS
PEDIATRIC USE
9
10
11
12
13
LOCAL REACTIONS
SYSTEMIC REACTIONS
14
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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