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GaviLyte G
Overview
What is GaviLyte G?
GaviLyte – G is a white powder in a 4 liter jug for reconstitution, containing 236 g polyethylene glycol 3350, 22.74 g sodium sulfate (anhydrous), 6.74 g sodium bicarbonate, 5.86 g sodium chloride and 2.97 g potassium chloride. When dissolved in water to a volume of 4 liters, GaviLyte – G (PEG-3350 (236 g) and Electrolytes for Oral Solution, USP) is an isosmotic solution, for oral administration, having a mildly salty taste. GaviLyte – G is administered orally or via nasogastric tube as a gastrointestinal lavage.
What does GaviLyte G look like?
What are the available doses of GaviLyte G?
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What should I talk to my health care provider before I take GaviLyte G?
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How should I use GaviLyte G?
GaviLyte – G is indicated for bowel cleansing prior colonoscopy and barium enema X-ray examination.
The recommended dose for adults is 4 liters of GaviLyte – G solution prior to gastrointestinal examination, as ingestion of this dose produces a satisfactory preparation in over 95% of patients. Ideally, the patients should fast for approximately three or four hours prior to GaviLyte – G administration, but in no case should solid food be given for at least two hours before the solution is given.
GaviLyte – G is usually administered orally, but may be given via nasogastric tube to patients who are unwilling or unable to drink the solution. is at a rate of 240 mL (8 oz.) every 10 Minutes, until 4 liters are consumed or the rectal effluent is clear. Rapid drinking of each portion is preferred to drinking small amounts continuously.
Nasogastric tube administration
Various regimens have been used. One method is to schedule patients for examination in midmorning or later, allowing the patients three hours for drinking and an additional one hour period for complete bowel evacuation. Another method is to administer GaviLyte – G on the evening before the examination, particularly if the patient is to have a barium enema.
Preparation of the solution:
What interacts with GaviLyte G?
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What are the warnings of GaviLyte G?
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What are the precautions of GaviLyte G?
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What are the side effects of GaviLyte G?
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What should I look out for while using GaviLyte G?
GaviLyte – G is contraindicated in patients known to hypersensitive to any of the components. GaviLyte – G is contraindicated in patients with gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis, toxic megacolon or ileus.
The lemon flavor pack is for use only in combination with the contents of the accompanying 4 liter container. No additional ingredients, e.g. flavorings, should be added to the solution. GaviLyte – G should be used with caution in patients with severe ulcerative colitis.
What might happen if I take too much GaviLyte G?
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How should I store and handle GaviLyte G?
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00GaviLyte – G is supplied in a disposable jug, in powdered form, for oral administration as a solution following reconstitution. Each jug has the attached lemon flavor pack, in powdered form, for the addition of the flavor packet by the pharmacist prior to dispensing.Disposable Jug:STORAGE:NDC 43386-090-19Manufactured by:Novel Laboratories, Inc.Somerset NJ 08873Distributed by:GAVIS Pharmaceuticals, LLCSomerset NJ 08873GLB-090-4L-00
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
GaviLyte – G induces a diarrhea which rapidly cleanses the bowel, usually within four hours. The osmotic activity of polyethylene glycol 3350 and the electrolyte concentration result in virtually no net absorption or excretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid or electrolyte balance.
Non-Clinical Toxicology
GaviLyte – G is contraindicated in patients known to hypersensitive to any of the components. GaviLyte – G is contraindicated in patients with gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis, toxic megacolon or ileus.The lemon flavor pack is for use only in combination with the contents of the accompanying 4 liter container. No additional ingredients, e.g. flavorings, should be added to the solution. GaviLyte – G should be used with caution in patients with severe ulcerative colitis.
No drug interactions have been identified. Studies with famotidine in man, in animal models, and have shown no significant interference with the disposition of compounds metabolized by the hepatic microsomal enzymes, e.g., cytochrome P450 system. Compounds tested in man include warfarin, theophylline, phenytoin, diazepam, aminopyrine and antipyrine. Indocyanine green as an index of hepatic drug extraction has been tested and no significant effects have been found.
Patients with impaired gag reflex, unconscious, or semiconscious patients, and patients prone to regurgitation or aspiration should be observed during the administration of GaviLyte – G, especially if it is administered via nasogastric tube. If a patient experiences severe bloating, distention or abdominal pain, administration should be slowed or temporarily discontinued until the symptoms abate. If gastrointestinal obstruction or perforation is suspected, appropriate studies should be performed to rule out these conditions before administration of GaviLyte – G.
Nausea, abdominal fullness and bloating are the most common adverse reactions (occurring in up to 50% of patients) to administration of GaviLyte – G. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient and subside rapidly. Isolated cases of urticaria, rhinorrhea, dermatitis and (rarely) anaphylactic reaction have been reported which may represent allergic reactions.
Published literature contains isolated reports of serious adverse reactions following the administration of PEG-ELS products in patients over 60 years of age. These adverse events include upper GI bleeding from Mallory-Weiss Tear, esophageal perforation, asystole, sudden dyspnea with pulmonary edema, and “butterfly-like" infiltrates on chest X-ray after vomiting and aspirating PEG.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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