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Polyethylene Glycol-3350 and Electrolytes with Flavor Pack

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Overview

What is Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

PEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is a white, colon lavage preparation provided as water-soluble components for solution. In solution this preparation with lemon flavor pack added delivers the following, in grams per liter.

Polyethylene glycol 3350 60.00

Sodium chloride 1.46

Potassium chloride 0.745

Sodium bicarbonate 1.68

Sodium sulfate 5.68

Flavor ingredients 0.500

When dissolved in sufficient water to make 4 liters, the final solution contains 125 mEq/L sodium, 10 mEq/L potassium, 20 mEq/L bicarbonate, 80 mEq/L sulfate, 35 mEq/L chloride and 18 mEq/L polyethylene glycol 3350. The reconstituted solution is an isosmotic solution, for oral administration, having mild salty taste. This preparation can be used without the lemon flavor pack and is administered orally or via nasogastric tube.

Each lemon flavor pack (2 g) contains natural lemon flavor powder, saccharin sodium, maltodextrin.



What does Polyethylene Glycol-3350 and Electrolytes with Flavor Pack look like?



What are the available doses of Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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What should I talk to my health care provider before I take Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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How should I use Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

PEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is indicated for bowel cleansing prior to colonoscopy or barium enema X-ray examination.

PEG-3350 (240 g) and electrolytes for oral solution with flavor pack can be administered orally or by nasogastric tube. Patients should fast at least 3 hours prior to administration. A one hour waiting period after the appearance of clear liquid stool should be allowed prior to examination to complete bowel evacuation. No foods except clear liquids should be permitted prior to examination after PEG-3350 (240 g) and electrolytes for oral solution with flavor pack administration.

ORAL:

The recommended adult oral dose is 240 mL (8 fl. oz.) every 10 minutes (see ). Lavage is complete when fecal discharge is clear. Lavage is usually complete after the ingestion of 3 to 4 liters.

NASOGASTRIC TUBE:

PEG-3350 (240 g) and electrolytes for oral solution with flavor pack is administered at a rate of 20 to 30 mL per minute (1.2 to 1.8 L/hour).

PREPARATION OF PEG-3350 (240 g)

and Electrolytes for Oral Solution, USP with flavor pack SOLUTION:

This preparation can be used with or without the lemon flavor pack.

Note: If not using flavor pack, omit steps one and two, above.


What interacts with Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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What are the warnings of Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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What are the precautions of Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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What are the side effects of Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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What should I look out for while using Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

PEG-3350 (240 g) and electrolytes for oral solution with flavor pack is contraindicated in patients known to be hypersensitive to any of the components. PEG-3350 (240 g) and electrolytes for oral solution with flavor pack is contraindicated in patients with ileus, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis or toxic megacolon.

Flavor pack is for use only in combination with the contents of the accompanying 4 liter container. No other additional ingredients (e.g., flavorings) should be added to the solution. PEG-3350 (240 g) and electrolytes for oral solution with flavor pack should be used with caution in patients with severe ulcerative colitis.


What might happen if I take too much Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

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How should I store and handle Polyethylene Glycol-3350 and Electrolytes with Flavor Pack?

Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP] .PEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USAPEG-3350 (240 g) and Electrolytes for Oral Solution, USP with flavor pack is supplied in 4 liter bottles with an attached lemon flavor pack. Each 4 liter bottle contains polyethylene glycol-3350 240 g, sodium chloride 5.84 g, potassium chloride 2.98 g, sodium bicarbonate 6.72 g, sodium sulfate (anhydrous) 22.72 g. This preparation is supplied in powdered form, for oral administration as a solution.PEG-3350 (240 g)and Electrolytes for Oral Solution, USP with flavor pack 4liter: NDC 40032-060-19Store at 20° to 25°C (68° to 77°F): excursions permitted between 15° to 30°C (59° to 86°F).KEEP RECONSTITUTED SOLUTION REFRIGERATED. USE WITHIN 48 HOURS. DISCARD UNUSED PORTION.Manufactured by:Novel Laboratories, Inc.400 Campus DriveSomerset, NJ 08873, USA


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Clinical Information

Chemical Structure

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Clinical Pharmacology

PEG-3350 (240 g) and electrolytes for oral solution with flavor pack cleanses the bowel by induction of diarrhea. The osmotic activity of polyethylene glycol 3350, in combination with the electrolyte concentration, results in virtually no net absorption or excretion of ions or water. Accordingly, large volumes may be administered without significant changes in fluid and electrolyte balance.

Non-Clinical Toxicology
PEG-3350 (240 g) and electrolytes for oral solution with flavor pack is contraindicated in patients known to be hypersensitive to any of the components. PEG-3350 (240 g) and electrolytes for oral solution with flavor pack is contraindicated in patients with ileus, gastrointestinal obstruction, gastric retention, bowel perforation, toxic colitis or toxic megacolon.

Flavor pack is for use only in combination with the contents of the accompanying 4 liter container. No other additional ingredients (e.g., flavorings) should be added to the solution. PEG-3350 (240 g) and electrolytes for oral solution with flavor pack should be used with caution in patients with severe ulcerative colitis.

In vitro, nilutamide has been shown to inhibit the activity of liver cytochrome P-450 isoenzymes and, therefore, may reduce the metabolism of compounds requiring these systems.

Consequently, drugs with a low therapeutic margin, such as vitamin K antagonists, phenytoin, and theophylline, could have a delayed elimination and increases in their serum half-life leading to a toxic level. The dosage of these drugs or others with a similar metabolism may need to be modified if they are administered concomitantly with nilutamide. For example, when vitamin K antagonists are administered concomitantly with nilutamide, prothrombin time should be carefully monitored and, if necessary, the dosage of vitamin K antagonists should be reduced.

Patients with impaired gag reflex, unconscious or semiconscious patients and patients prone to regurgitation or aspiration should be observed during the administration of PEG-3350 (240 g) and electrolytes for oral solution with flavor pack, especially if it is administered via nasogastric tube.

If gastrointestinal obstruction or perforation is suspected appropriate studies should be performed to rule out these conditions before administration of PEG-3350 (240 g) and electrolytes for oral solution with flavor pack.

Nausea, abdominal fullness and bloating are the most frequent adverse reactions, occurring in up to 50% of patients. Abdominal cramps, vomiting and anal irritation occur less frequently. These adverse reactions are transient. Isolated cases of urticaria, rhinorrhea, dermatitis, and rarely anaphylaxis, angioedema, tongue edema, and face edema have been reported which may represent allergic reactions.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

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