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Cholestyramine
Overview
What is Cholestyramine?
Cholestyramine for Oral Suspension USP, the chloride salt of a basic anion
exchange resin, a cholesterol lowering agent, is intended for oral
administration. Cholestyramine resin is quite hydrophilic, but insoluble in
water. The cholestyramine resin in Cholestyramine is not absorbed from the
digestive tract. Four grams of anhydrous cholestyramine resin is contained in 9
grams of Cholestyramine for Oral Suspension USP. Four grams of anhydrous
cholestyramine resin is contained in 5 grams of Cholestyramine for Oral
Suspension USP, Light. It is represented by the following structural formula:
Cholestyramine for Oral Suspension USP contains the following inactive
ingredients: acacia, citric acid, D&C Yellow No. 10, FD&C Yellow No. 6,
flavor (natural and artificial Orange), polysorbate 80, propylene glycol
alginate and sucrose. Cholestyramine for Oral Suspension USP, Light contains the
following inactive ingredients: aspartame, citric acid, colloidal silicon
dioxide, D&C Yellow No. 10, FD&C Red No. 40, flavor (natural and
artificial Orange), maltodextrin, propylene glycol alginate and xanthan gum.
What does Cholestyramine look like?
What are the available doses of Cholestyramine?
Sorry No records found.
What should I talk to my health care provider before I take Cholestyramine?
Sorry No records found
How should I use Cholestyramine?
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Cholestyramine should not be taken in its dry form. Always mix
Cholestyramine with water or other fluids before ingesting. See Preparation
Instructions.
Drug Interactions
PRECAUTIONS
What interacts with Cholestyramine?
Cholestyramine for oral suspension is contraindicated in patients with complete biliary obstruction where bile is not secreted into the intestine and in those individuals who have shown hypersensitivity to any of its components.
What are the warnings of Cholestyramine?
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What are the precautions of Cholestyramine?
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BEFORE
AFTER
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5
PRECAUTIONS: Drug Interactions
“Pregnancy”
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(6,7)
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ADVERSE
REACTIONS
What are the side effects of Cholestyramine?
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What should I look out for while using Cholestyramine?
Cholestyramine for oral suspension is contraindicated in patients with complete
biliary obstruction where bile is not secreted into the intestine and in those
individuals who have shown hypersensitivity to any of its components.
PHENYLKETONURICS: CHOLESTYRAMINE for ORAL SUSPENSION USP, LIGHT
CONTAINS 14.0 mg PHENYLALANINE PER 5 GRAM DOSE.
What might happen if I take too much Cholestyramine?
Overdosage with Cholestyramine has been reported in a patient taking 150% of the
maximum recommended daily dosage for a period of several weeks. No ill effects
were reported. Should an overdosage occur, the chief potential harm would be
obstruction of the gastrointestinal tract. The location of such potential
obstruction, the degree of obstruction, and the presence or absence of normal
gut motility would determine treatment.
How should I store and handle Cholestyramine?
Store at 20°-25°C (68°-77°F) (see USP Controlled Room Temperature). PROTECT FROM LIGHT. KEEP TIGHTLY CLOSED. Sarafem is a registered trademark of Eli Lilly and Company.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Non-Clinical Toxicology
Cholestyramine for oral suspension is contraindicated in patients with complete biliary obstruction where bile is not secreted into the intestine and in those individuals who have shown hypersensitivity to any of its components.PHENYLKETONURICS: CHOLESTYRAMINE for ORAL SUSPENSION USP, LIGHT CONTAINS 14.0 mg PHENYLALANINE PER 5 GRAM DOSE.
Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE-inhibitors. This interaction should be given consideration in patients taking NSAIDs concomitantly with ACE-inhibitors.
When nabumetone in administered with aspirin, its protein binding is reduced, although the clearance of free nabumetone is not altered. The clinical significance of this interaction is not known; however, as with other NSAIDs, concomitant administration of nabumetone and aspirin is not generally recommended because of the potential of increased adverse effects.
Clinical studies, as well as post marketing observations, have shown that nabumetone can reduce the natriuretic effect of furosemide and thiazides in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis. During concomitant therapy with NSAIDs, the patient should be observed closely for signs of renal failure (see ), as well as to assure diuretic efficacy.
NSAIDs have produced an elevation of plasma lithium levels and a reduction in renal lithium clearance. The mean minimum lithium concentration increased 15% and the renal clearance was decreased by approximately 20%. These effects have been attributed to inhibition of renal prostaglandin synthesis by the NSAID. Thus, when NSAIDs and lithium are administered concurrently, subjects should be observed carefully for signs of lithium toxicity.
NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices. This may indicate that they could enhance the toxicity of methotrexate. Caution should be used when NSAIDs are administered concomitantly with methotrexate.
The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious GI bleeding higher than users of either drug alone.
In vitro studies have shown that, because of its affinity for protein, 6MNA may displace other protein-bound drugs from their binding site. Caution should be exercised when administering Nabumetone with warfarin since interactions have been seen with other NSAIDs.
Concomitant administration of an aluminum-containing antacid had not significant effect on the bioavailability of 6MNA. When administered with food or milk, there is more rapid absorption; however, the total amount of 6MNA in the plasma is unchanged (see ).
BEFORE
AFTER
5
PRECAUTIONS: Drug Interactions
“Pregnancy”
(6,7)
ADVERSE REACTIONS
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Interactions
Interactions
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