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Hybrisil

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Overview

What is Hybrisil?

DESCRIPTION

Chemical Name

Contains



What does Hybrisil look like?



What are the available doses of Hybrisil?

Sorry No records found.

What should I talk to my health care provider before I take Hybrisil?

Sorry No records found

How should I use Hybrisil?

HybriSil™ topical gel is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid responsive dermatoses, including those associated with the formation of scar tissue.

HybriSil™ (methylprednisolone acetate 1%) silicone gel should be applied to the affected area as a thin film two or three times daily depending on the severity of the condition. Occlusive dressings may be used for management of recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.


What interacts with Hybrisil?

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. 



What are the warnings of Hybrisil?

Sorry No Records found


What are the precautions of Hybrisil?

General: Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia and glucosuria in some patients.Conditions which augment systemic absorption include the application of more potent steroid use over large surface areas, prolonged use and addition of occlusive dressings.Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests.  If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of applications, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug.  Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Children may absorb proportionately larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.  (See PRECAUTIONS-Pediatric Use) This medication contains alcohol.   It may produce irritation or burning sensations on open lesions.  If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. As with any topical corticosteroid product, prolonged use may produce atrophy of the skin and subcutaneous tissues.  When used on intertriginous or flexor areas, or on the face, this may occur even with short-term use.In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted.  If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled. 


What are the side effects of Hybrisil?

Sorry No records found


What should I look out for while using Hybrisil?

Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. 


What might happen if I take too much Hybrisil?

topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects (see )


How should I store and handle Hybrisil?

Store at 25º C (77º F); excursions permitted to 15–30C (59–86F) .in 30 gm bottle with pump.  Prescription only.US Patents:    Pending.    Revised April 2011


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

T

Non-Clinical Toxicology
Topical corticosteroids are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation. 

Anticoagulants (oral): The

b−Hyperthyroidism may cause increased clearance of beta blockers with a high extraction

ratio. A dose reduction of betaadrenergic blockers may be needed when a hyperthyroid patient becomes euthyroid.

Digitalis glycosides: Serum

glycoside regimen become euthyroid; reduced dosage of digitalis glycosides may be required.

Theophylline:

Theophylline clearance may decrease when hyperthyroid patients on a stable theophylline regimen become euthyroid; a reduced

dose of theophylline may be needed.

General: Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia and glucosuria in some patients.Conditions which augment systemic absorption include the application of more potent steroid use over large surface areas, prolonged use and addition of occlusive dressings.Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests.  If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of applications, or to substitute a less potent steroid. Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug.  Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Children may absorb proportionately larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity.  (See PRECAUTIONS-Pediatric Use) This medication contains alcohol.   It may produce irritation or burning sensations on open lesions.  If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. As with any topical corticosteroid product, prolonged use may produce atrophy of the skin and subcutaneous tissues.  When used on intertriginous or flexor areas, or on the face, this may occur even with short-term use.In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted.  If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled. 

The following local adverse reactions are reported infrequently with topical corticosteroids but may occur more frequently with the use of occlusive dressings.  These reactions are listed in an approximate decreasing order of occurrence:Burning, Itching, Irritation, Dryness, Folliculitis, Hypertrichosis, Acneiform eruptions, Hypopigmentation, Perioral dermatitis, Allergic contract dermatitis, Maceration of the skin, Secondary infection, Skin atrophy, Striae and Miliaria.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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