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Retin-A MICRO

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Overview

What is Retin-A MICRO?

Retin-A Micro (tretinoin) Gel microsphere, 0.1%, 0.08%, 0.06% and 0.04% is a white to very pale yellow opaque gel for topical treatment of acne vulgaris.

Chemically, tretinoin is all-trans-retinoic acid, also known as (all-E)-3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. It is a member of the retinoid class of compounds and a metabolite of naturally occurring Vitamin A. Tretinoin has a molecular weight of 300.44, a molecular formula of CHO and the following chemical structure:

Each gram of Retin-A Micro Gel, 0.1%, contains 1 mg of tretinoin.

Each gram of Retin-A Micro Gel, 0.08%, contains 0.8 mg of tretinoin.

Each gram of Retin-A Micro Gel, 0.06%, contains 0.6 mg of tretinoin.

Each gram of Retin-A Micro Gel, 0.04%, contains 0.4 mg of tretinoin.

The formulation uses methyl methacrylate/glycol dimethacrylate crosspolymer porous microspheres (MICROSPONGE System) to enable inclusion of the active ingredient, tretinoin, in an aqueous gel. Other components consist of benzyl alcohol, butylated hydroxytoluene, carbomer 974P, cyclomethicone and dimethicone copolyol, disodium EDTA, glycerin, PPG-20 methyl glucose ether distearate, propylene glycol, purified water, sorbic acid, and trolamine.



What does Retin-A MICRO look like?



What are the available doses of Retin-A MICRO?

Gel, 0.1%, 0.08%, 0.06%, and 0.04% ()

What should I talk to my health care provider before I take Retin-A MICRO?

Retin-A Micro should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There are no adequate and well-controlled studies in pregnant and nursing women.

How should I use Retin-A MICRO?

Retin-A Micro is a retinoid indicated for topical application in the treatment of acne vulgaris.

For topical use only. Not for ophthalmic, oral, or intravaginal use.

Retin-A Micro should be applied once a day, in the evening, to the skin where acne lesions appear, using enough to cover the entire affected area in a thin layer. Areas to be treated should be cleansed thoroughly before the medication is applied. If medication is applied excessively, no more rapid or better results will be obtained and marked redness, peeling, or discomfort may occur. A transitory feeling of warmth or slight stinging may be noted on application. In cases where it has been necessary to temporarily discontinue therapy or to reduce the frequency of application, therapy may be resumed or the frequency of application increased as the patient becomes able to tolerate the treatment. Frequency of application should be closely monitored by careful observation of the clinical therapeutic response and skin tolerance. Efficacy has not been established for less than once daily dosing frequencies.

During the early weeks of therapy, an apparent exacerbation of inflammatory lesions may occur. If tolerated, this should not be considered a reason to discontinue therapy [see ].

Therapeutic results may be noticed after two weeks, but more than seven weeks of therapy are required before consistent beneficial effects are observed.

Retin-A Micro should be kept away from the eyes, the mouth, paranasal creases of the nose, and mucous membranes.

Patients treated with Retin-A Micro may use cosmetics.

Concomitant topical medication, medicated or abrasive soaps and cleansers, products that have a strong drying effect, products with high concentrations of alcohol, astringents, or spices should be used with caution because of possible interaction with tretinoin. Avoid contact with the peel of limes. Particular caution should be exercised with the concomitant use of topical over-the-counter acne preparations containing benzoyl peroxide, sulfur, resorcinol, or salicylic acid with Retin-A Micro. It also is advisable to allow the effects of such preparations to subside before use of Retin-A Micro is begun.


What interacts with Retin-A MICRO?

Sorry No Records found


What are the warnings of Retin-A MICRO?

Sorry No Records found


What are the precautions of Retin-A MICRO?

Sorry No Records found


What are the side effects of Retin-A MICRO?

Sorry No records found


What should I look out for while using Retin-A MICRO?

None.


What might happen if I take too much Retin-A MICRO?

Oral ingestion of large amounts of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.


How should I store and handle Retin-A MICRO?

Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Store pump upright.Keep out of reach of children.Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Store pump upright.Keep out of reach of children.Store at 20° to 25°C (68° to 77°F); excursions permitted from 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Store pump upright.Keep out of reach of children.20 mg Tablets: NDC 68788-6920-3 Bottles of 30 tablets NDC 68788-6920-6 Bottles of 60 tabletsNDC 68788-6920-9 Bottles of 90 tabletsNDC 68788-6920-1 Bottles of 100 tablets 20 mg Tablets: NDC 68788-6920-3 Bottles of 30 tablets NDC 68788-6920-6 Bottles of 60 tabletsNDC 68788-6920-9 Bottles of 90 tabletsNDC 68788-6920-1 Bottles of 100 tablets 20 mg Tablets: NDC 68788-6920-3 Bottles of 30 tablets NDC 68788-6920-6 Bottles of 60 tabletsNDC 68788-6920-9 Bottles of 90 tabletsNDC 68788-6920-1 Bottles of 100 tablets 20 mg Tablets: NDC 68788-6920-3 Bottles of 30 tablets NDC 68788-6920-6 Bottles of 60 tabletsNDC 68788-6920-9 Bottles of 90 tabletsNDC 68788-6920-1 Bottles of 100 tablets 20 mg Tablets: NDC 68788-6920-3 Bottles of 30 tablets NDC 68788-6920-6 Bottles of 60 tabletsNDC 68788-6920-9 Bottles of 90 tabletsNDC 68788-6920-1 Bottles of 100 tablets


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Although tretinoin activates three members of the retinoic acid (RAR) nuclear receptors (RARα, RARβ, and RARγ) which may act to modify gene expression, subsequent protein synthesis, and epithelial cell growth and differentiation, it has not been established whether the clinical effects of tretinoin are mediated through activation of retinoic acid receptors and/or other mechanisms.

The exact mode of action of tretinoin is unknown. Current evidence suggests that topical tretinoin decreases cohesiveness of follicular epithelial cells with decreased microcomedone formation. Additionally, tretinoin stimulates mitotic activity and increased turnover of follicular epithelial cells causing extrusion of the comedones.

Non-Clinical Toxicology
None.

The skin of certain individuals may become excessively dry, red, swollen, or blistered.

Tretinoin has been reported to cause severe irritation on eczematous skin and should be used with utmost caution in patients with this condition.

If the degree of irritation warrants, patients should be directed to temporarily reduce the amount or frequency of application of the medication, discontinue use temporarily, or discontinue use all together. Efficacy at reduced frequencies of application has not been established. If a reaction suggesting sensitivity occurs, use of the medication should be discontinued.

To help limit skin irritation, patients must

Patients should apply a topical moisturizer if dryness is bothersome.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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