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IsonaRif
Overview
What is IsonaRif?
Rifampin/Isoniazid is a combination capsule containing 300 mg rifampin and 150 mg isoniazid. Each capsule for oral administration, contain the following inactive ingredients: colloidal silicon dioxide, corn starch, lactose monohydrate,magnesium stearate, and pregelatinized starch.
Capsule shell contains: FD&C blue #1, FD&C red #40, gelatin and titanium dioxide.
The printing ink contains: ammonium hydroxide, isopropyl alcohol, N-butyl alcohol, pharmaceutical glaze, propylene glycol, simethicone, and titanium dioxide.
Rifampin is a semisynthetic antibiotic derivative of rifamycin B. The chemical name for rifampin is 3-(4-methyl-1-piperazinyliminomethyl) rifamycin SV.
Isoniazid is the hydrazide of isonicotinic acid. It exists as colorless or white crystals or as a white crystalline powderthat is water soluble, odorless and slowly affected by exposure to air and light.
What does IsonaRif look like?
What are the available doses of IsonaRif?
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What should I talk to my health care provider before I take IsonaRif?
Sorry No records found
How should I use IsonaRif?
For pulmonary tuberculosis in which organisms are susceptible, and when the patient has been titrated on theindividual components and it has therefore been established that this fixed dosage is therapeutically effective.
This fixed-dosage combination drug is not recommended for initial therapy of tuberculosis or for preventive therapy.
In the treatment of tuberculosis, small numbers of resistant cells, present within large populations of susceptiblecells, can rapidly become the predominating type. Since rapid emergence of resistance can occur, culture andsusceptibility tests should be performed in the event of persistent positive cultures.
This drug is not indicated for the treatment of meningococcal infections or asymptomatic carriers of to eliminate meningococci from the nasopharynx.
In general, therapy should be continued until bacterial conversion and maximal improvement have occurred.
Adults: Two Rifampin and Isoniazid Capsules, USP (600 mg rifampin, 300 mg isoniazid) once daily, administeredone hour before or two hours after a meal.
Concomitant administration of pyridoxine (B6) is recommended in the malnourished, in those predisposed toneuropathy (e.g., diabetic), and in adolescents.
Susceptibility Testing, Rifampin
Rifampin susceptibility powders are available for both direct and indirect methods of determining the susceptibility of strains of mycobacteria. The MIC's of susceptible clinical isolates when determined in 7H10 or other non-eggcontainingmedia have ranged from 0.1 to 2 mcg/mL. Quantitative methods that require measurement of zonediameters give the most precise estimates of antibiotic susceptibility. One such procedure has been recommendedfor use with discs for testing susceptibility to rifampin. Interpretations correlate zone diameters from the disc testwith MIC (minimal inhibitory concentration) values for rifampin.
What interacts with IsonaRif?
Previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid, such as drug fever, chills, andarthritis; acute liver disease of any etiology. A history of previous hypersensitivity reaction to any of the rifamycinsor to isoniazid, including drug-induced hepatitis.
What are the warnings of IsonaRif?
If isosorbide mononitrate is used in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia.
Rifampin and isoniazid capsules are a combination of two drugs, each of which has been associated with liverdysfunction. Liver function tests should be performed prior to therapy with rifampin/isoniazid and periodicallyduring treatment.
Rifampin
Rifampin has been shown to produce liver dysfunction. There have been fatalities associated with jaundice inpatients with liver disease or receiving rifampin concomitantly with other hepatoxic agents. Since an increased riskmay exist for individuals with liver disease, benefits must be weighed carefully against the risk of further liver damage.
Several studies of tumorigenicity potential have been done in rodents. In one strain of mice known to be particularlysusceptible to the spontaneous development of hepatomas, rifampin given at a level 2-10 times the maximumdosage used clinically resulted in a significant increase in the occurrence of hepatomas in female mice of this strainafter one year of administration.
There was no evidence of tumorigenicity in the males of this strain, in males or females of another mouse strain, orin rats.
Isoniazid
See the .
What are the precautions of IsonaRif?
Array
Rifampin
Rifampin is not recommended for intermittent therapy; the patient should be cautioned against intentional oraccidental interruption of the daily dosage regimen since rare renal hypersensitivity reactions have been reportedwhen therapy was resumed in such cases.
Rifampin has been observed to increase the requirements for anticoagulant drugs of the coumarin type. The causeof the phenomenon is unknown. In patients receiving anticoagulants and rifampin concurrently, it is recommendedthat the prothrombin time be performed daily or as frequently as necessary to establish and maintain the requireddose of anticoagulant. Urine, feces, saliva, sputum, sweat, and tears may be colored red-orange by rifampin and itsmetabolites. Soft contact lenses may be permanently stained. Individuals to be treated should be made aware of these possibilities.
It has been reported that the reliability of oral contraceptives may be affected in some patients being treated fortuberculosis with rifampin in combination with at least one other antituberculosis drug. In such cases, alternativecontraceptive measures may need to be considered.
It has also been reported that rifampin given in combination with other antituberculosis drugs may decrease thepharmacologic activity of methadone, oral hypoglycemics, digitoxin, quinidine, disopyramide, dapsone, and corticosteroids.In these cases, dosage adjustment of the interacting drugs is recommended.
Therapeutic levels of rifampin have been shown to inhibit standard microbiological assays for serum folate andvitamin B12. Alternative methods must be considered when determining folate and vitamin B12 concentrations inthe presence of rifampin.
Since rifampin has been reported to cross the placental barrier and appear in cord blood and in maternal milk,neonates and newborns of rifampin-treated mothers should be carefully observed for any evidence of untowardeffects.
Array
- Patients who are receiving phenytoin (diphenylhydantoin) concurrently. Isoniazid may decrease the excretion of phenytoin or may enhance its effects. To avoid phenytoin intoxication, appropriate adjustment of the anticonvulsant dose should be made.
- Daily users of alcohol. Daily ingestion of alcohol may be associated with a higher incidence of isoniazid hepatitis.
- Patients with current chronic liver disease or severe renal dysfunction.
Isoniazid
All drugs should be stopped and an evaluation of the patient should be made at the first sign of a hypersensitivity reaction.
Use of isoniazid should be carefully monitored in the following:
Periodic ophthalmoscopic examination during isoniazid therapy is recommended when visual symptoms occur.
Usage in Pregnancy and Lactation
Carcinogenesis:
Isoniazid has been reported to induce pulmonary tumors in a number of strains of mice.
What are the side effects of IsonaRif?
Rifampin
Nervous system reactions:
Gastrointestinal disturbances:
Hepatic reactions:
Renal reactions:
Hematologic reactions:
Allergic and immunological reactions:
Although rifampin has been reported to have an immunosuppressive effect in some animal experiments, availablehuman data indicate that this has no clinical significance.
Metabolic reactions:
Miscellaneous reactions:
Isoniazid
The most frequent reactions are those affecting the nervous system and the liver.
Nervous system reactions:
Other neurotoxic effects, which are uncommon with conventional doses are convulsions, toxic encephalopathy,optic neuritis and atrophy, memory impairment, and toxic psychosis.
Gastrointestinal reactions:
Hepatic reactions:
Hematologic reactions:
Hypersensitivity reactions:
Metabolic and endocrine reactions:
Miscellaneous reactions:
What should I look out for while using IsonaRif?
Previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid, such as drug fever, chills, andarthritis; acute liver disease of any etiology. A history of previous hypersensitivity reaction to any of the rifamycinsor to isoniazid, including drug-induced hepatitis.
Rifampin and isoniazid capsules are a combination of two drugs, each of which has been associated with liverdysfunction. Liver function tests should be performed prior to therapy with rifampin/isoniazid and periodicallyduring treatment.
Rifampin
Rifampin has been shown to produce liver dysfunction. There have been fatalities associated with jaundice inpatients with liver disease or receiving rifampin concomitantly with other hepatoxic agents. Since an increased riskmay exist for individuals with liver disease, benefits must be weighed carefully against the risk of further liver damage.
Several studies of tumorigenicity potential have been done in rodents. In one strain of mice known to be particularlysusceptible to the spontaneous development of hepatomas, rifampin given at a level 2-10 times the maximumdosage used clinically resulted in a significant increase in the occurrence of hepatomas in female mice of this strainafter one year of administration.
There was no evidence of tumorigenicity in the males of this strain, in males or females of another mouse strain, orin rats.
Isoniazid
See the .
What might happen if I take too much IsonaRif?
Rifampin
Signs and Symptoms:
Liver enlargement, possibly with tenderness, can develop within a few hours after severe overdosage, and jaundicemay develop rapidly. Hepatic involvement may be more marked in patients with prior impairment of hepatic function.Other physical findings remain essentially normal.
Direct and total bilirubin levels may increase rapidly with severe overdosage; hepatic enzyme levels may be affected, especially with prior impairment of hepatic function. A direct effect upon hemopoietic system, electrolyte levels, or acid-base balance is unlikely.
Isoniazid
Signs and Symptoms:
Treatment
The airway should be secured and adequate respiratory exchange established. Only then should gastric emptying(lavage-aspiration) be attempted; this may be difficult because of seizures. Since nausea and vomiting are likely tobe present, gastric lavage is probably preferable to induction of emesis.
Activated charcoal slurry instilled into the stomach following evacuation of gastric contents can help absorb anyremaining drug in the GI tract. Antiemetic medication may be required to control severe nausea and vomiting.
Blood samples should be obtained for immediate determination of gases, electrolytes, BUN, glucose, etc. Bloodshould be typed and cross matched in preparation for possible hemodialysis.
Rapid control of metabolic acidosis is fundamental to management. Intravenous sodium bicarbonate should begiven at once and repeated as needed, adjusting subsequent dosage on the basis of laboratory findings (i.e., serumsodium, pH, etc.). At the same time, anticonvulsants should be given intravenously (i.e., barbiturates, diphenylhydantoin, diazepam) as required, and large doses of intravenous pyridoxine.
Forced osmotic diuresis must be started early and should be continued for some hours after clinical improvementto hasten renal clearance of drug and help prevent relapse. Fluid intake and output should be monitored.
Bile drainage may be indicated in presence of serious impairment of hepatic function lasting more than 24-48hours. Under these circumstances and for severe cases, extracorporeal hemodialysis may be required; if this is notavailable, peritoneal dialysis can be used along with forced diuresis.
Along with measures based on initial and repeated determination of blood gases and other laboratory tests as needed,meticulous respiratory and other intensive care should be utilized to protect against hypoxia, hypotension, aspiration,pneumonitis, etc.
In patients with previously adequate hepatic function, reversal of liver enlargement and impaired hepatic excretoryfunction probably will be noted within 72 hours, with rapid return toward normal thereafter.
Untreated or inadequately treated cases of gross isoniazid overdosage can terminate fatally, but good response hasbeen reported in most patients brought under adequate treatment within the first few hours after drug ingestion.
How should I store and handle IsonaRif?
Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007Rifampin and Isoniazid Capsules USP, 300 mg/150 mg are supplied as red powder filled No. 0 Scarlet Opaque HardGelatin Capsules; printed "IsonaRif™" on one end and “VP/017” on the other end in white ink; bottles of 60 capsules (NDC#61748-017-60).Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.Keep tightly closed. Store in a dry place. Avoid excessive heat.Store at 20-25°C (68-77°F) [See USP Controlled Room Temperature]. Protect from light and moisture.Manufactured for:VersaPharm IncorporatedMarietta, GA 30062Manufactured by:West-ward Pharmaceutical CorpEatontown, NJ 07724Rev. Feb. 2007
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Rifampin
Rifampin inhibits DNA-dependent RNA polymerase activity in susceptible cells. Specifically, it interacts with bacterialRNA polymerase but does not inhibit the mammalian enzyme. This is the mechanism of action by which rifampinexerts its therapeutic effect. Rifampin cross resistance has only been shown with other rifamycins.
In a study of 14 normal human adult males, peak blood levels of rifampin occurred 1½ to 3 hours following oraladministration of two rifampin and isoniazid capsules. The peaks ranged from 6.9 to 14 mcg/ml with an average of10 mcg/ml.
In normal subjects the T½ (biological half-life) of rifampin in blood is approximately 3 hours. Elimination occursmainly through the bile and, to a much lesser extent, the urine.
Isoniazid
Isoniazid acts against actively growing tubercle bacilli.
After oral administration isoniazid produces peak blood levels within 1 to 2 hours which decline to 50% or lesswithin 6 hours. It diffuses readily into all body fluids (cerebrospinal, pleural, and ascitic fluids), tissues, organs,and excreta (saliva, sputum, and feces). The drug also passes through the placental barrier and into milk inconcentrations comparable to those in the plasma. From 50 to 70% of a dose of isoniazid is excreted in the urine in 24 hours.
Isoniazid is metabolized primarily by acetylation and dehydrazination. The rate of acetylation is genetically determined.Approximately 50% of Blacks and Caucasians are "slow inactivators"; the majority of Eskimos and Orientalsare "rapid inactivators."
The rate of acetylation does not significantly alter the effectiveness of isoniazid. However, slow acetylation maylead to higher blood levels of the drug, and thus an increase in toxic reactions.
Pyridoxine deficiency (B6) is sometimes observed in adults with high doses of isoniazid and is considered probablydue to its competition with pyridoxal phosphate for the enzyme apotryptophanase.
Non-Clinical Toxicology
Previous isoniazid-associated hepatic injury; severe adverse reactions to isoniazid, such as drug fever, chills, andarthritis; acute liver disease of any etiology. A history of previous hypersensitivity reaction to any of the rifamycinsor to isoniazid, including drug-induced hepatitis.Rifampin and isoniazid capsules are a combination of two drugs, each of which has been associated with liverdysfunction. Liver function tests should be performed prior to therapy with rifampin/isoniazid and periodicallyduring treatment.
Rifampin
Rifampin has been shown to produce liver dysfunction. There have been fatalities associated with jaundice inpatients with liver disease or receiving rifampin concomitantly with other hepatoxic agents. Since an increased riskmay exist for individuals with liver disease, benefits must be weighed carefully against the risk of further liver damage.
Several studies of tumorigenicity potential have been done in rodents. In one strain of mice known to be particularlysusceptible to the spontaneous development of hepatomas, rifampin given at a level 2-10 times the maximumdosage used clinically resulted in a significant increase in the occurrence of hepatomas in female mice of this strainafter one year of administration.
There was no evidence of tumorigenicity in the males of this strain, in males or females of another mouse strain, orin rats.
Isoniazid
See the .
The vasodilating effects of isosorbide mononitrate may be additive with those of other vasodilators. Alcohol, in particular, has been found to exhibit additive effects of this variety.
Marked symptomatic orthostatic hypotension has been reported when calcium channel blockers and organic nitrates were used in combination. Dose adjustments of either class of agents may be necessary.
Rifampin is not recommended for intermittent therapy; the patient should be cautioned against intentional oraccidental interruption of the daily dosage regimen since rare renal hypersensitivity reactions have been reportedwhen therapy was resumed in such cases.
Rifampin has been observed to increase the requirements for anticoagulant drugs of the coumarin type. The causeof the phenomenon is unknown. In patients receiving anticoagulants and rifampin concurrently, it is recommendedthat the prothrombin time be performed daily or as frequently as necessary to establish and maintain the requireddose of anticoagulant. Urine, feces, saliva, sputum, sweat, and tears may be colored red-orange by rifampin and itsmetabolites. Soft contact lenses may be permanently stained. Individuals to be treated should be made aware of these possibilities.
It has been reported that the reliability of oral contraceptives may be affected in some patients being treated fortuberculosis with rifampin in combination with at least one other antituberculosis drug. In such cases, alternativecontraceptive measures may need to be considered.
It has also been reported that rifampin given in combination with other antituberculosis drugs may decrease thepharmacologic activity of methadone, oral hypoglycemics, digitoxin, quinidine, disopyramide, dapsone, and corticosteroids.In these cases, dosage adjustment of the interacting drugs is recommended.
Therapeutic levels of rifampin have been shown to inhibit standard microbiological assays for serum folate andvitamin B12. Alternative methods must be considered when determining folate and vitamin B12 concentrations inthe presence of rifampin.
Since rifampin has been reported to cross the placental barrier and appear in cord blood and in maternal milk,neonates and newborns of rifampin-treated mothers should be carefully observed for any evidence of untowardeffects.
Rifampin
Nervous system reactions:
Gastrointestinal disturbances:
Hepatic reactions:
Renal reactions:
Hematologic reactions:
Allergic and immunological reactions:
Although rifampin has been reported to have an immunosuppressive effect in some animal experiments, availablehuman data indicate that this has no clinical significance.
Metabolic reactions:
Miscellaneous reactions:
Isoniazid
The most frequent reactions are those affecting the nervous system and the liver.
Nervous system reactions:
Other neurotoxic effects, which are uncommon with conventional doses are convulsions, toxic encephalopathy,optic neuritis and atrophy, memory impairment, and toxic psychosis.
Gastrointestinal reactions:
Hepatic reactions:
Hematologic reactions:
Hypersensitivity reactions:
Metabolic and endocrine reactions:
Miscellaneous reactions:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
Interactions
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