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L-Methylfolate Calcium

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Overview

What is L-Methylfolate Calcium?

L-Methylfolate Calcium 15 mg is an orally administered prescription dietary supplement specifically formulated for the dietary management of patients with unique nutritional needs requiring increased folate levels.

L-Methylfolate Calcium 15 mg should be administered under the supervision of a licensed medical practitioner.

Each coated, oblong, orange tablet contains the following dietary ingredient:

Other ingredients: Croscarmellose sodium, dicalcium phosphate, magnesium stearate, microcrystalline cellulose, silicon dioxide, stearic acid, and film coat (FD&C red #2, FD&C yellow #6 lake, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide).

This product contains FD&C Yellow #6 Lake.



What does L-Methylfolate Calcium look like?



What are the available doses of L-Methylfolate Calcium?

Sorry No records found.

What should I talk to my health care provider before I take L-Methylfolate Calcium?

Sorry No records found

How should I use L-Methylfolate Calcium?

L-Methylfolate Calcium 15 mg is indicated for the distinct nutritional requirements of patients in need of dietary supplementation as determined by a licensed medical practitioner. L-Methylfolate Calcium 15 mg should be administered under the supervision of a licensed medical practitioner.

The usual adult dose is 15 mg daily with or without food or as directed by a licensed medical practitioner.


What interacts with L-Methylfolate Calcium?

This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.



What are the warnings of L-Methylfolate Calcium?

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What are the precautions of L-Methylfolate Calcium?

General

Folate, when administered as a single agent in doses about 0.1 mg daily, may obscure the detection of vitamin B deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B deficiency, including pernicious anemia, while not addressing the neurological manifestations).

Folate therapy alone is inadequate for treatment of a vitamin B deficiency.

A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed, (although not established in controlled trials) that treating such an episode with an antidepressant alone may increase the likelihood of a precipitation of a mixed/manic episode in patients at risk for bipolar disorder. L-Methylfolate Calcium 15 mg is not an antidepressant; however, folate has been shown to enhance antidepressant effects of known antidepressants. Caution is recommended in patients with a history of bipolar illness.

Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder since mood elevation in this population is possible.

PATIENT INFORMATION

L-Methylfolate Calcium 15 mg is a prescription dietary supplement to be used only under licensed medical supervision.

DRUG INTERACTIONS

  • Antiepileptic drugs (AED): The AED class including, but not limited to, phenytoin, carbamazepine, primidone, valproic acid, fosphenytoin, valproate, phenobarbital and lamotrigine have been shown to impair folate absorption and increase the metabolism of circulating folate.
  • Additionally, concurrent use of folic acid has been associated with enhanced phenytoin metabolism, lowering the level of the AED in the blood and allowing breakthrough seizures to occur. Caution should be used when prescribing this product among patients who are receiving treatment with phenytoin and other anticonvulsants.
  • Capecitabine: Folinic acid (5-formyltetrahydrofolate) may increase the toxicity of Capecitabine.
  • Cholestyramine: Reduces folic acid absorption and reduces serum folate levels.
  • Colestipol: Reduces folic acid absorption and reduces serum folate levels.
  • Cycloserine: Reduces folic acid absorption and reduces serum folate levels.
  • Dihydrofolate Reductase Inhibitors (DHFRI): DHFRIs block the conversion of folic acid to its active forms, and lower plasma and red blood cell folate levels. DHFRIs include aminopterin, methotrexate, pyrimethamine, triamterene, and trimethoprim.
  • Fluoxetine: Fluoxetine exerts a noncompetitive inhibition of the 5-methyltetrahydrofolate active transport in the intestine.
  • Isotretinoin: Reduced folate levels have occurred in some patients taking isotretinoin.
  • L-dopa, triamterene, colchicine, and trimethoprim may decrease plasma folate levels.
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): NSAIDs have been shown to inhibit some folate dependent enzymes in laboratory experiments. NSAIDs include ibuprofen, naproxen, indomethacin and sulindac.
  • Oral Contraceptives: Serum folate levels may be depressed by oral contraceptive therapy.
  • Methylprednisolone: Reduced serum folate levels have been noted after treatment with methylprednisolone.
  • Pancreatic Enzymes: Reduced folate levels have occurred in some patients taking pancreatic extracts, such as pancreatin and pancrelipase.
  • Pentamidine: Reduced folate levels have been seen with prolonged intravenous pentamidine.
  • Pyrimethamine: High levels of folic acid may result in decreased serum levels of pyrimethamine.
  • Smoking and Alcohol: Reduced serum folate levels have been noted.
  • Sulfasalazine: Inhibits the absorption and metabolism of folic acid.
  • Metformin treatment in patients with type 2 diabetes decreases serum folate.
  • Warfarin can produce significant impairment in folate status after a 6-month therapy.
  • Folinic acid may enhance the toxicity of fluorouracil.
  • Concurrent administration of chloramphenicol and folinic acid in folate-deficient patients may result in antagonism of the haematopoietic response to folate.
  • Caution should be exercised with the concomitant use of folinic acid and trimethoprim-sulfamethoxazole for the acute treatment of pneumonia in patients with HIV infection as it is associated with increased rates of treatment failure and mortality in a placebo controlled study.


Drugs which may interact with folate include:

PREGNANCY and NURSING MOTHERS

L-Methylfolate Calcium 15 mg is not intended for use as a prenatal/postnatal multivitamin for lactating and non-lactating mothers. This product contains a B vitamin in reduced form. Talk with your medical practitioner before using if pregnant or lactating.


What are the side effects of L-Methylfolate Calcium?

Allergic sensitization has been reported following both oral and parental administration of folic acid, and may possibly occur with other forms of folate.


What should I look out for while using L-Methylfolate Calcium?

This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.

Caution is recommended in patients with a history of bipolar illness.


What might happen if I take too much L-Methylfolate Calcium?

Sorry No Records found


How should I store and handle L-Methylfolate Calcium?

Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 Store between 2° - 30°C (36° - 86°F).Sulfonamide solutions, on long standing, will darken in color and should be discarded.KEEP OUT OF REACH OF CHILDREN.Revised November 2007Bausch & Lomb Incorporated©Bausch & Lomb Incorporated9113200 9113300 L-Methylfolate Calcium 15 mg tablets are coated, oblong, orange tablets debossed "BP" on top and "1000" on bottom, and are supplied in bottles of 90 tablets.NDC 76439--90 (90 ct. bottle / 90 tablets)L-Methylfolate Calcium 15 mg tablets are coated, oblong, orange tablets debossed "BP" on top and "1000" on bottom, and are supplied in bottles of 90 tablets.NDC 76439--90 (90 ct. bottle / 90 tablets)


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Non-Clinical Toxicology
This product is contraindicated in patients with a known hypersensitivity to any of the ingredients.

Caution is recommended in patients with a history of bipolar illness.

Drugs which may interact with folate include:

Folate, when administered as a single agent in doses about 0.1 mg daily, may obscure the detection of vitamin B deficiency (specifically, the administration of folic acid may reverse the hematological manifestations of B deficiency, including pernicious anemia, while not addressing the neurological manifestations).

Folate therapy alone is inadequate for treatment of a vitamin B deficiency.

A major depressive episode may be the initial presentation of bipolar disorder. It is generally believed, (although not established in controlled trials) that treating such an episode with an antidepressant alone may increase the likelihood of a precipitation of a mixed/manic episode in patients at risk for bipolar disorder. L-Methylfolate Calcium 15 mg is not an antidepressant; however, folate has been shown to enhance antidepressant effects of known antidepressants. Caution is recommended in patients with a history of bipolar illness.

Patients with depressive symptoms should be adequately screened to determine if they are at risk for bipolar disorder since mood elevation in this population is possible.

Allergic sensitization has been reported following both oral and parental administration of folic acid, and may possibly occur with other forms of folate.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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