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PROCRIT

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Overview

What is PROCRIT?

Epoetin alfa is a 165-amino acid erythropoiesis-stimulating glycoprotein manufactured by recombinant DNA technology. It has a molecular weight of approximately 30,400 daltons and is produced by mammalian cells into which the human erythropoietin gene has been introduced. The product contains the identical amino acid sequence of isolated natural erythropoietin.

PROCRIT (epoetin alfa) injection for intravenous or subcutaneous administration is formulated as a sterile, clear, colorless liquid in vials in multiple formulations. Single-dose vials, formulated with an isotonic sodium chloride/sodium citrate-buffered solution, are supplied in multiple strengths. Each single-dose 1 mL vial contains 2,000, 3,000, 4,000, or 10,000 Units of epoetin alfa, Albumin (Human) (2.5 mg), citric acid (0.06 mg), sodium chloride (5.9 mg), and sodium citrate (5.8 mg) in Water for Injection, USP (pH 6.9 ± 0.3). Single-dose 1 mL vials formulated with an isotonic sodium chloride/sodium phosphate buffer contain 40,000 Units of epoetin alfa albumin (human) (2.5 mg), citric acid (0.0068 mg), sodium chloride (5.8 mg), sodium citrate (0.7 mg), sodium phosphate dibasic anhydrate (1.8 mg), and sodium phosphate monobasic monohydrate (1.2 mg) in Water for Injection, USP (pH 6.9 ± 0.3). Multiple-dose, 2 mL vials contain 10,000 Units epoetin alfa, albumin (human) (2.5 mg), benzyl alcohol (1%), sodium chloride (8.2 mg), citric acid (0.11 mg), and sodium citrate (1.3 mg) per 1 mL Water for Injection, USP (pH 6.1 ± 0.3). Multiple-dose 1 mL vials contain 20,000 Units epoetin alfa, albumin (human) (2.5 mg), benzyl alcohol (1%), sodium chloride (8.2 mg), citric acid (0.11 mg), and sodium citrate (1.3 mg), per 1 mL in Water for Injection, USP (pH 6.1 ± 0.3).



What does PROCRIT look like?



What are the available doses of PROCRIT?

Injection:

What should I talk to my health care provider before I take PROCRIT?

How should I use PROCRIT?

PROCRIT is indicated for the treatment of anemia due to chronic kidney disease (CKD), including patients on dialysis and not on dialysis to decrease the need for red blood cell (RBC) transfusion.

Evaluate iron status before and during treatment and maintain iron repletion. Correct or exclude other causes of anemia before initiating treatment ().

In pregnant women, lactating women, neonates, infants: Use only single-dose vials ().

Patients with CKD: Initial dose: 50 to 100 Units/kg 3 times weekly (adults) and 50 Units/kg 3 times weekly (pediatric patients). Individualize maintenance dose. Intravenous route recommended for patients on hemodialysis ().

Patients on Zidovudine due to HIV-infection: 100 Units/kg 3 times weekly ().

Patients with Cancer on Chemotherapy: 40,000 Units weekly or 150 Units/kg 3 times weekly (adults); 600 Units/kg intravenously weekly (pediatric patients ≥ 5 years) ().

Surgery Patients: 300 Units/kg per day daily for 15 days or 600 Units/kg weekly ().


What interacts with PROCRIT?

Sorry No Records found


What are the warnings of PROCRIT?

Sorry No Records found


What are the precautions of PROCRIT?

Sorry No Records found


What are the side effects of PROCRIT?

Sorry No records found


What should I look out for while using PROCRIT?

PROCRIT is contraindicated in patients with:

PROCRIT from multiple-dose vials contains benzyl alcohol and is contraindicated in:


What might happen if I take too much PROCRIT?

PROCRIT overdosage can cause hemoglobin levels above the desired level, which should be managed with discontinuation or reduction of PROCRIT dosage and/or with phlebotomy, as clinically indicated . Cases of severe hypertension have been observed following overdose with ESAs


How should I store and handle PROCRIT?

Store at 20°C to 25°C (68°F to 77°F) [See USP controlled room temperature]. Protect from moisture.PROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vialsPROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vialsPROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vialsPROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vialsPROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vialsPROCRIT (epoetin alfa) injection is a sterile, clear, and colorless solution available as:Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in citrate-buffered formulation)Preservative-free, single-dose vials (in phosphate-buffered formulation)Preserved, multiple-dose vialsPreserved, multiple-dose vials


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

PROCRIT stimulates erythropoiesis by the same mechanism as endogenous erythropoietin.

Non-Clinical Toxicology
PROCRIT is contraindicated in patients with:

PROCRIT from multiple-dose vials contains benzyl alcohol and is contraindicated in:

The following drug interactions were studied with ketoprofen doses of 200 mg/day. The possibility of increased interaction should be kept in mind when ketoprofen capsule doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs.

The design and overall results of the 3 large trials comparing higher and lower hemoglobin targets are shown in Table 1.

The following serious adverse reactions are discussed in greater detail in other sections of the label:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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