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Mematine Hydrochloride

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Overview

What is Mematine Hydrochloride?

Memantine hydrochloride is an orally active NMDA receptor antagonist. The chemical name for memantine hydrochloride is 1-amino-3,5-dimethyladamantane hydrochloride with the following structural formula:

The molecular formula is CHN•HCl and the molecular weight is 215.76.

Memantine HCl occurs as a fine white to off-white powder and is soluble in water. Memantine hydrochloride is available as tablets. Memantine hydrochloride is available for oral administration as capsule-shaped, film-coated tablets containing 5 mg and 10 mg of memantine hydrochloride. The tablets also contain the following inactive ingredients: microcrystalline cellulose, talc, croscarmellose sodium, colloidal silicon dioxide, magnesium stearate and anhydrous lactose. In addition the following inactive ingredients are also present as components of the film coat: hypromellose, titanium dioxide, macrogol/polyethylene glycol 4000, FD&C yellow #6, iron oxide red and FD&C blue #2 (5 mg tablets), and hypromellose, titanium dioxide, macrogol/polyethylene glycol 4000 and FD&C blue #2 (10 mg tablets).



What does Mematine Hydrochloride look like?



What are the available doses of Mematine Hydrochloride?

Sorry No records found.

What should I talk to my health care provider before I take Mematine Hydrochloride?

Sorry No records found

How should I use Mematine Hydrochloride?

Memantine hydrochloride is indicated for the treatment of moderate to severe dementia of the Alzheimer’s type.

The dosage of memantine hydrochloride shown to be effective in controlled clinical trials is 20 mg/day.

The recommended starting dose of memantine hydrochloride is 5 mg once daily. The recommended target dose is 20 mg/day. The dose should be increased in 5 mg increments to 10 mg/day (5 mg twice a day), 15 mg/day (5 mg and 10 mg as separate doses), and 20 mg/day (10 mg twice a day). The minimum recommended interval between dose increases is one week.

Memantine hydrochloride can be taken with or without food.


What interacts with Mematine Hydrochloride?

Sorry No Records found


What are the warnings of Mematine Hydrochloride?

Sorry No Records found


What are the precautions of Mematine Hydrochloride?

Sorry No Records found


What are the side effects of Mematine Hydrochloride?

Sorry No records found


What should I look out for while using Mematine Hydrochloride?

Memantine hydrochloride is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation.


What might happen if I take too much Mematine Hydrochloride?

Because strategies for the management of overdose are continually evolving, it is advisable to contact a poison control center to determine the latest recommendations for the management of an overdose of any drug.

As in any cases of overdose, general supportive measures should be utilized, and treatment should be symptomatic. Elimination of memantine can be enhanced by acidification of urine. In a documented case of an overdosage with up to 400 mg of memantine, the patient experienced restlessness, psychosis, visual hallucinations, somnolence, stupor and loss of consciousness. The patient recovered without permanent sequelae.


How should I store and handle Mematine Hydrochloride?

5 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/115 mg Tablet:Bottle of 60                                                                       NDC # 68820-068-09Bottle of 500                                                                      NDC # 68820-068-1210 x 10 Unit Dose                                                               NDC # 68820-068-1110 mg Tablet:Bottle of 60                                                                       NDC # 68820-069-09Bottle of 500                                                                     NDC # 68820-069-1210 x 10 Unit Dose                                                              NDC # 68820-069-11Store at 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Manufactured byOrchid Healthcare(A Division of Orchid Chemicals & Pharmaceuticals Ltd.)Irungattukottai - 602 105, IndiaManufactured forOrgenus Pharma, Inc.700 Alexander Park, Suite 104,Princeton, NJ 08540, USAIssued: 04/11


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Persistent activation of central nervous system N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer’s disease. Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels. There is no evidence that memantine prevents or slows neurodegeneration in patients with Alzheimer’s disease.

Memantine showed low to negligible affinity for GABA, benzodiazepine, dopamine, adrenergic, histamine and glycine receptors and for voltage-dependent Ca, Na or Kchannels. Memantine also showed antagonistic effects at the 5HT receptor with a potency similar to that for the NMDA receptor and blocked nicotinic acetylcholine receptors with one-sixth to one-tenth the potency.

In vitro

Non-Clinical Toxicology
Memantine hydrochloride is contraindicated in patients with known hypersensitivity to memantine hydrochloride or to any excipients used in the formulation.

Caution must be exercised in the administration of 3% and 5% Sodium Chloride Injection, USP to patients treated with drugs that may increase the risk of sodium and fluid retention, such as corticosteroids.

Caution is advised in patients treated with lithium. Renal sodium and lithium clearance may be increased during the administration of 3% and 5% Sodium Chloride Injection, USP. Administration of 3% and 5% Sodium Chloride Injection, USP may, therefore, result in decreased lithium levels.

Caregivers should be instructed in the recommended administration (twice per day for doses above 5 mg) and dose escalation (minimum interval of one week between dose increases).

The experience described in this section derives from studies in patients with Alzheimer’s disease and vascular dementia.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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