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Nuvessa

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Overview

What is Nuvessa?

NUVESSA contains 1.3% metronidazole, USP in a single-dose prefilled disposable applicator. It is intended for intravaginal use. Metronidazole is a nitroimidazole antimicrobial.

Chemically, metronidazole is a 2-methyl-5-nitroimidazole-1-ethanol. Its structural formula is:

The molecular formula is CHNO with a molecular weight of 171.16.

NUVESSA is an aqueous gel containing metronidazole at a concentration of 13 mg/g (1.3%). The gel is formulated at pH 4.0. The gel also contains benzyl alcohol, methylparaben, polycarbophil, polyethylene glycol 400, propylene glycol, propylparaben, and purified water.

Each applicator contains approximately 65 mg of metronidazole in 5 g of vaginal gel.



What does Nuvessa look like?



What are the available doses of Nuvessa?

Vaginal gel 65 mg of metronidazole in 5 grams of gel (1.3%) in a prefilled applicator ()

What should I talk to my health care provider before I take Nuvessa?

Nursing Mothers: Consider discontinuation of breastfeeding for 24 hours after NUVESSA use. ()

How should I use Nuvessa?

NUVESSA is indicated in the treatment of bacterial vaginosis in non-pregnant women.

A single-dose, pre-filled disposable applicator (which delivers approximately 5 g of gel containing 65 mg of metronidazole) administered once intravaginally. NUVESSA should be administered at bedtime.

NUVESSA is not for ophthalmic, dermal or oral use.


What interacts with Nuvessa?

Sorry No Records found


What are the warnings of Nuvessa?

Sorry No Records found


What are the precautions of Nuvessa?

Sorry No Records found


What are the side effects of Nuvessa?

Sorry No records found


What should I look out for while using Nuvessa?

History of hypersensitivity to metronidazole, parabens, other ingredients of the formulation, or other nitroimidazole derivatives ()

Concomitant use of disulfiram or within 2 weeks of disulfiram (, )

Concomitant use of alcohol (, )


What might happen if I take too much Nuvessa?

There is no human experience with overdosage of metronidazole vaginal gel. Vaginally applied NUVESSA could be absorbed in sufficient amounts to produce systemic effects [ and .


How should I store and handle Nuvessa?

Store lyophilized Activase at controlled room temperature not to exceed 30°C (86°F), or under refrigeration (2-8°C/36-46°F). Protect the lyophilized material during extended storage from excessive exposure to light. If stored between 2-30°C (36-86°F), Activase may be used within 8 hours following reconstitution. Discard any unused solution after administration is complete.Do not use beyond the expiration date stamped on the vial.Store lyophilized Activase at controlled room temperature not to exceed 30°C (86°F), or under refrigeration (2-8°C/36-46°F). Protect the lyophilized material during extended storage from excessive exposure to light. If stored between 2-30°C (36-86°F), Activase may be used within 8 hours following reconstitution. Discard any unused solution after administration is complete.Do not use beyond the expiration date stamped on the vial.NUVESSA is available in cartons containing one single-dose, prefilled disposable applicator delivering 5 g of vaginal gel containing approximately 65 mg of metronidazole:


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Metronidazole is an antimicrobial drug [].

Non-Clinical Toxicology
History of hypersensitivity to metronidazole, parabens, other ingredients of the formulation, or other nitroimidazole derivatives ()

Concomitant use of disulfiram or within 2 weeks of disulfiram (, )

Concomitant use of alcohol (, )

Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Therefore, it should be used with caution in patients receiving such agents.

Antagonism has been demonstrated between clindamycin and erythromycin Because of possible clinical significance, these two drugs should not be administered concurrently.

Convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity, have been reported in patients treated with oral or intravenous metronidazole. NUVESSA should be administered with caution to patients with central nervous system diseases.

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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