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Cystografin
Overview
What is Cystografin?
Cystografin is a radiopaque contrast
agent supplied as a sterile, clear, colorless to pale yellow, mobile
or slightly viscous solution. Each mL provides 300 mg diatrizoate
meglumine with 0.4 mg edetate disodium as a sequestering agent. Each
mL of solution also contains approximately 141 mg organically bound
iodine. At the time of manufacture, the air in the container is replaced
by nitrogen. The preparation should be protected from strong light.
What does Cystografin look like?
What are the available doses of Cystografin?
Sorry No records found.
What should I talk to my health care provider before I take Cystografin?
Sorry No records found
How should I use Cystografin?
Cystografin is indicated for retrograde
cystourethrography.
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Preparation of the patient:
What interacts with Cystografin?
This preparation is contraindicated in patients with a hypersensitivity to salts of diatrizoic acid.
What are the warnings of Cystografin?
Trihexyphenidyl should be administered with caution in hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, alcoholics, those who have central nervous system disease, or those who do manual labor in a hot environment. Anhidrosis may occur more readily when some disturbance of sweating already exists. If there is evidence of anhidrosis, the possibility of hyperthermia should be considered. Dosage should be decreased so that the ability to maintain body heat equilibrium via perspiration is not impaired. Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics under the conditions described above.
Severe sensitivity reactions are
more likely to occur in patients with a personal or family history
of bronchial asthma, significant allergies, or previous reactions
to contrast agents.
A
history of sensitivity to iodine or to other
contrast agents is not an absolute contraindication to the use of
diatrizoate meglumine, but calls for extreme caution in administration.
What are the precautions of Cystografin?
Safe and effective use of this
preparation depends upon proper dosage, correct technique, adequate
precautions, and readiness for emergencies.
Retrograde cystourethrography should be performed
with caution in patients with a known active infectious process of
the urinary tract.
Sterile
technique should be employed in administration. During administration,
care should be taken to avoid excessive pressure, rapid or acute distention
of the bladder, and trauma.
Contrast agents may interfere with some chemical determinations made
on urine specimens; therefore, urine should be collected before administration
of the contrast medium or two or more days afterwards.
Pregnancy—Teratogenic Effects: Pregnancy Category C
Animal reproduction studies have
not been conducted with diatrizoate meglumine injection. It is also
not known whether diatrizoate meglumine injection can cause fetal
harm when administered to a pregnant woman or can affect reproduction
capacity. Cystografin should be administered to a pregnant woman only
if clearly needed.
What are the side effects of Cystografin?
Retrograde genitourinary procedures
may cause such complications as hematuria, perforation of the urethra
or bladder, introduction of infection into the genitourinary tract,
and oliguria or anuria.
If intravasation of this drug occurs, the reactions which may be
associated with intravenous administration may possibly be encountered.
Hypersensitivity or anaphylactoid reactions may occur. Severe reactions
may be manifested by edema of the face and glottis, respiratory distress,
convulsions or shock; such reactions may prove fatal unless promptly
controlled by such emergency measures as maintenance of a clear airway
and immediate use of oxygen and resuscitative drugs.
Endocrine:
What should I look out for while using Cystografin?
This preparation is contraindicated
in patients with a hypersensitivity to salts of diatrizoic acid.
Severe sensitivity reactions are
more likely to occur in patients with a personal or family history
of bronchial asthma, significant allergies, or previous reactions
to contrast agents.
A
history of sensitivity to iodine or to other
contrast agents is not an absolute contraindication to the use of
diatrizoate meglumine, but calls for extreme caution in administration.
What might happen if I take too much Cystografin?
Sorry No Records found
How should I store and handle Cystografin?
Store at 20-25°C (68-77°F) [See USP]. Protect from light.Cystografin (Diatrizoate Meglumine Injection USP 30%) is available in 200 mL and 400 mL bottles containing 100 mL and 300 mL of Cystografin respectively with sufficient capacity for dilution up to 167 mL and 350 mL respectively.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Non-Clinical Toxicology
This preparation is contraindicated in patients with a hypersensitivity to salts of diatrizoic acid.Severe sensitivity reactions are more likely to occur in patients with a personal or family history of bronchial asthma, significant allergies, or previous reactions to contrast agents.
A history of sensitivity to iodine or to other contrast agents is not an absolute contraindication to the use of diatrizoate meglumine, but calls for extreme caution in administration.
Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibiotics or potent diuretics such as furosemide. Renal function should be carefully monitored, especially if higher dosages of the aminoglycosides are to be administered or if therapy is prolonged, because of the potential nephrotoxicity and ototoxicity of aminoglycoside antibiotics. Nephrotoxicity and ototoxicity were not noted when ceftazidime was given alone in clinical trials.
Chloramphenicol has been shown to be antagonistic to beta-lactam antibiotics, including ceftazidime, based on studies and time kill curves with enteric gram-negative bacilli. Due to the possibility of antagonism , particularly when bactericidal activity is desired, this drug combination should be avoided.
In common with other antibiotics, ceftazidime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Safe and effective use of this preparation depends upon proper dosage, correct technique, adequate precautions, and readiness for emergencies.
Retrograde cystourethrography should be performed with caution in patients with a known active infectious process of the urinary tract.
Sterile technique should be employed in administration. During administration, care should be taken to avoid excessive pressure, rapid or acute distention of the bladder, and trauma.
Contrast agents may interfere with some chemical determinations made on urine specimens; therefore, urine should be collected before administration of the contrast medium or two or more days afterwards.
Retrograde genitourinary procedures may cause such complications as hematuria, perforation of the urethra or bladder, introduction of infection into the genitourinary tract, and oliguria or anuria.
If intravasation of this drug occurs, the reactions which may be associated with intravenous administration may possibly be encountered. Hypersensitivity or anaphylactoid reactions may occur. Severe reactions may be manifested by edema of the face and glottis, respiratory distress, convulsions or shock; such reactions may prove fatal unless promptly controlled by such emergency measures as maintenance of a clear airway and immediate use of oxygen and resuscitative drugs.
Endocrine:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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