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Morphine

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Overview

What is Opium Tincture Deodorized?

Opium Tincture, USP (Deodorized), is for oral administration. It is freed from unpleasant odor or nauseating substances by “denarcotization” with a petroleum distillate. Opium tincture is a clear, reddish-brown hydroalcoholic solution.

Each 100 mL contains 1 g of anhydrous morphine (represents the equivalent of 10 g of Powdered Opium, USP), alcohol, 19%, and water.

Opium has a very characteristic odor and a very bitter taste. The opiates are the most effective and prompt-acting nonspecific antidiarrheal agents.



What does Opium Tincture Deodorized look like?



What are the available doses of Opium Tincture Deodorized?

Sorry No records found.

What should I talk to my health care provider before I take Opium Tincture Deodorized?

Sorry No records found

How should I use Opium Tincture Deodorized?

Opium tincture is useful for the treatment of diarrhea.

Usual Adult Dose


What interacts with Opium Tincture Deodorized?

This preparation is not recommended for use in children. It should not be used in diarrhea caused by poisoning until the toxic material is eliminated from the gastrointestinal tract.



What are the warnings of Opium Tincture Deodorized?

Liver toxicities including fatalities have been reported (See ). Baseline and periodic assessment of hepatic function should be performed.


What are the precautions of Opium Tincture Deodorized?

General

Drug Interactions

Usage in Pregnancy - Pregnancy Category C

Nursing Mothers

Usage in Children


What are the side effects of Opium Tincture Deodorized?

Constipation, nausea, and vomiting may occur in some patients. Pruritus and urticaria have been observed.


What should I look out for while using Opium Tincture Deodorized?

This preparation is not recommended for use in children. It should not be used in diarrhea caused by poisoning until the toxic material is eliminated from the gastrointestinal tract.

Addiction can result from opium usage. Opium preparations should be given in the smallest effective dose and as infrequently as possible to minimize the development of tolerance and physical dependence.


What might happen if I take too much Opium Tincture Deodorized?

Signs and Symptoms

Treatment

Physicians’ Desk Reference (PDR)

Initial management of opioid overdose should emphasize establishment of a secure airway and support of ventilation and perfusion. Meticulously monitor and maintain, within acceptable limits, the patient’s vital signs, blood gases, serum electrolytes, blood glucose, etc. Naloxone antagonizes most effects of opioids. Protect the airway as naloxone may induce vomiting. Since naloxone has a shorter duration of action than opioids, repeated doses may be needed. In patients who abuse opioids chronically, a withdrawal syndrome may be manifest on administration of naloxone. This may include yawning, tearing, restlessness, sweating, dilated pupils, piloerection, vomiting, diarrhea, and abdominal cramps. This syndrome usually abates quickly as the effect of naloxone dissipates.

Absorption of drugs from the gastrointestinal tract may be decreased by giving activated charcoal, which, in many cases, is more effective than emesis or lavage; consider charcoal instead of or in addition to gastric emptying. Repeated doses of charcoal over time may hasten elimination of some drugs that have been absorbed. Since opium tincture can delay gastric emptying, evacuation of the stomach may be beneficial. Safeguard the patient’s airway when employing gastric emptying or charcoal. Monitor for and treat hypoglycemia.

The use of forced diuresis, peritoneal dialysis, hemodialysis or charcoal hemoperfusion has not been established to be beneficial.


How should I store and handle Opium Tincture Deodorized?

Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published []. Opium Tincture, USP (Deodorized), is supplied as:Store at controlled room temperature, 68° to 77°F (20° to 25°C) (see USP).Manufactured for:Opium Tincture, USP (Deodorized), is supplied as:Store at controlled room temperature, 68° to 77°F (20° to 25°C) (see USP).Manufactured for:Opium Tincture, USP (Deodorized), is supplied as:Store at controlled room temperature, 68° to 77°F (20° to 25°C) (see USP).Manufactured for:


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

The opiates act by enhancing tone in the long segments of longitudinal muscle and by inhibiting propulsive contraction of both circular and longitudinal muscles.

Clinical evidence indicates that the analgesic activity of opium preparations is due to their morphine content. Relatively small doses that do not produce significant analgesia are effective in controlling diarrhea. The papaverine content of the mixed alkaloids is too small to have demonstrable spasmolytic activity.

Following oral administration, morphine is well absorbed from the gastrointestinal tract. It is rapidly metabolized following oral administration, however, and plasma levels of unconjugated morphine are lower than those achieved after parenteral administration. Like other narcotic analgesics, opium preparations are metabolized in the liver. Morphine undergoes conjugation with glucuronic acid at the 3-hydroxyl group. Secondary conjugation may also occur at the 6-hydroxyl group to form the 3,6-diglucuronide. Morphine is excreted in the urine mainly as morphine-3-glucuronide and smaller amounts of morphine-3,6-diglucuronide and unchanged drug. Approximately 75% of a dose of morphine is excreted in the urine within 48 hours.

Non-Clinical Toxicology
This preparation is not recommended for use in children. It should not be used in diarrhea caused by poisoning until the toxic material is eliminated from the gastrointestinal tract.

Addiction can result from opium usage. Opium preparations should be given in the smallest effective dose and as infrequently as possible to minimize the development of tolerance and physical dependence.

Absorption of other oral medications may be decreased during concurrent use with anticholinergics due to decreased gastrointestinal motility and delayed gastric emptying.

Drug interactions may occur when anticholinergics are used with the following medications: antacids, antidiarrheals (adsorbent), other anticholinergics, antimyasthenics, cyclopropane, haloperidol, ketoconazole, metoclopramide, opioid (narcotic) analgesics, and potassium chloride.

General

Drug Interactions

Usage in Pregnancy - Pregnancy Category C

Nursing Mothers

Usage in Children

Constipation, nausea, and vomiting may occur in some patients. Pruritus and urticaria have been observed.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

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Interactions

Interactions

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