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Zolmitriptan OD
Overview
What is Zolmitriptan OD?
Zolmitriptan orally disintegrating tablets contain zolmitriptan, which is a selective 5-hydroxytryptamine(5-HT) receptor agonist. Zolmitriptan is chemically designated as (S)-4-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-2-oxazolidinone and has the following chemical structure:
The molecular formula is CHNO, representing a molecular weight of 287.36. Zolmitriptan is white to cream colored crystalline powder that is freely soluble in methanol, slightly soluble in ethyl acetate and very slightly soluble in water.
Zolmitriptan orally disintegrating tablets are available for oral administration as 2.5 mg and 5 mg, white colored, round shaped, flat faced, beveled edged tablets. Each orally disintegrating tablet contains acesulfame potassium, aminomethacrylate copolymer, colloidal silicon dioxide, crospovidone, low-substituted hydroxypropyl cellulose, magnesium aluminometasilicate, magnesium stearate, mannitol, peppermint flavor, sodium lauryl sulfate and talc.
What does Zolmitriptan OD look like?
What are the available doses of Zolmitriptan OD?
• Orally Disintegrating Tablets: 2.5 mg and 5 mg ()
What should I talk to my health care provider before I take Zolmitriptan OD?
How should I use Zolmitriptan OD?
Zolmitriptan is indicated for the acute treatment of migraine with or without aura in adults.
The recommended starting dose of zolmitriptan is 1.25 mg or 2.5 mg. The 1.25 mg dose can be achieved by manually breaking the functionally-scored 2.5 mg tablet in half. The maximum recommended single dose of zolmitriptan is 5 mg.
In controlled clinical trials, a greater proportion of patients had headache response following a 2.5 mg or 5 mg dose than following a 1 mg dose. There was little added benefit from the 5 mg dose compared to the 2.5 mg dose, but adverse reactions were more frequent with the 5 mg dose.
If the migraine has not resolved by 2 hours after taking zolmitriptan, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 10 mg in any 24-hour period.
The safety of zolmitriptan in the treatment of an average of more than three migraines in a 30-day period has not been established.
What interacts with Zolmitriptan OD?
Sorry No Records found
What are the warnings of Zolmitriptan OD?
Sorry No Records found
What are the precautions of Zolmitriptan OD?
Sorry No Records found
What are the side effects of Zolmitriptan OD?
Sorry No records found
What should I look out for while using Zolmitriptan OD?
Zolmitriptan is contraindicated in patients with:
What might happen if I take too much Zolmitriptan OD?
There is no experience with acute overdose of zolmitriptan. Clinical study subjects who received single 50 mg oral doses of zolmitriptan commonly experienced sedation.
There is no specific antidote to zolmitriptan. In cases of severe intoxication, intensive care procedures are recommended, including establishing and maintaining a patent airway, ensuring adequate oxygenation and ventilation, and monitoring and support of the cardiovascular system.
The elimination half-life of zolmitriptan is 3 hours [see ]; therefore, monitor patients after overdose with zolmitriptan for at least 15 hours or until symptoms or signs resolve. It is unknown what effect hemodialysis or peritoneal dialysis has on the plasma concentrations of zolmitriptan.
How should I store and handle Zolmitriptan OD?
2.5 mg Orally Disintegrating Tablets5 mg Orally Disintegrating Tablets2.5 mg Orally Disintegrating Tablets5 mg Orally Disintegrating Tablets
