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Phentermine HCl

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Overview

What is Phentermine HCl?

View chemical structure at permanent link below.

Phentermine Hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether.

Phentermine hydrochloride is available as: a) powder-filled capsules containing 15 mg Phentermine hydrochloride (equivalent to 12 mg Phentermine) or 30 mg Phentermine hydrochloride (equivalent to 24 mg Phentermine) and inactive ingredients: corn starch, gelatin, lactose monohydrate and magnesium stearate. In addition, the 15 mg capsules contain D&C Yellow #10, FD&C Blue #1, FD&C Red #3, FD&C Red #40, titanium dioxide and the 30 mg capsules contain D&C Yellow #10, FD&C Red #3, titanium dioxide. b) bead-filled capsules containing 30 mg Phentermine hydrochloride (equivalent to 24 mg Phentermine) and inactive ingredients: corn starch, sucrose, hypromellose, povidone, and talc. In addition, the capsule contains FD&C blue #1/Brilliant blue FCF Aluminum Lake, D&C red #28 and gelatin.

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6



What does Phentermine HCl look like?



What are the available doses of Phentermine HCl?

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

What should I talk to my health care provider before I take Phentermine HCl?

8.1 Pregnancy Pregnancy category X Phentermine is contraindicated during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. A minimum weight gain, and no weight loss, is currently recommended for all pregnant women, including those who are already overweight or obese, due to obligatory weight gain that occurs in maternal tissues during pregnancy. Phentermine has pharmacologic activity similar to amphetamine (d- and d/l-amphetamine) [see Clinical Pharmacology (12.1)]. Animal reproduction studies have not been conducted with phentermine. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus.

8.2 [no data]

8.3 Nursing Mothers It is not known if Phentermine is excreted in human milk; however, other amphetamines are present in human milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

8.4 Pediatric Use Safety and effectiveness in pediatric patients have not been established. Because pediatric obesity is a chronic condition requiring long-term treatment, the use of this product, approved for short-term therapy, is not recommended.

8.5 Geriatric Use In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

8.6 Renal Impairment Based on the reported excretion of Phentermine in urine, exposure increases can be expected in patients with renal impairment [see Clinical Pharmacology (12.3)].

Use caution when administering phentermine hydrochloride to patients with renal impairment. In patients with severe renal impairment (eGFR 15 to 29 mL/min/1.73 m2), limit the dosage of phentermine hydrochloride to 15 mg daily [see Dosage and Administration (2.2)]. Phentermine hydrochloride has not been studied in patients with eGFR less than 15 mL/min/1.73 m2, including end-stage renal disease requiring dialysis; avoid use in these populations.

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

How should I use Phentermine HCl?

View image at Permanent Link listed below.

The limited usefulness of agents of this class, including Phentermine hydrochloride, [see CLINICAL PHARMACOLOGY ( 12.1, 12.2)] should be measured against possible risk factors inherent in their use such as those described below.

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

2.2 Dosage in Patients With Renal Impairment The recommended maximum dosage of phentermine hydrochloride is 15 mg daily for patients with severe renal impairments (eGFR 15 to 29 mL/min/1.73 m2). Avoid use of phentermine hydrochloride in patients with eGFR less than 15 mL/min/1.73 m2 or end-stage renal disease requiring dialysis [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)].

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6


What interacts with Phentermine HCl?

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What are the warnings of Phentermine HCl?

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What are the precautions of Phentermine HCl?

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What are the side effects of Phentermine HCl?

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What should I look out for while using Phentermine HCl?

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6


What might happen if I take too much Phentermine HCl?

10.1 Acute Overdosage Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include tachycardia, arrhythmia, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea and abdominal cramps. Overdosage of pharmacologically similar compounds has resulted in fatal poisoning usually terminates in convulsions and coma. Management of acute phentermine hydrochloride intoxication is largely symptomatic and includes lavage and sedation with a barbiturate. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard. Acidification of the urine increases phentermine excretion. Intravenous phentolamine (Regitine®, CIBA) has been suggested on pharmacologic grounds for possible acute, severe hypertension, if this complicates overdosage.

10.2 Chronic Intoxication Manifestations of chronic intoxication with anorectic drugs include severe dermatoses, marked insomnia, irritability, hyperactivity and personality changes. The most severe manifestation of chronic intoxications is psychosis, often clinically indistinguishable from schizophrenia. See Drug Abuse and Dependence (9.3).

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6


How should I store and handle Phentermine HCl?

Store at 20º-25º C (68º-77º F); excursions permitted to 15 to 30º C (59 to 86º F) [see USP Controlled Room Temperature].Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6 Phentermine Hydrochloride capsules, USP are available as follows:Phentermine Hydrochloride capsules, USP 15 mg are supplied as gray opaque cap, rich yellow opaque body with black imprint “K 26” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-026-03 Bottles of 100, NDC 10702-026-01 Bottles of 1000, NDC 10702-026-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as rich yellow opaque cap, rich yellow opaque body with black imprint “K 27” on both the cap and body, filled with powder. Bottles of 30, NDC 10702-027-03 Bottles of 100, NDC 10702-027-01 Bottles of 1000, NDC 10702-027-10 Phentermine Hydrochloride capsules, USP 30 mg are supplied as blue cap, natural body with black imprint “K 28” on both the cap and body, filled with white and blue colored beads. Bottles of 30, NDC 10702-028-03 Bottles of 100, NDC 10702-028-01 Bottles of 1000, NDC 10702-028-10 Store at 20° to 25°C (68° to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature].Dispense in a tight, light resistant container as defined in the USP, with a child-resistant closure (as required). Keep out of the reach of childrenPlease review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

12.1 Mechanism of Action Phentermine is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, amphetamine (d- and dll-amphetamine). Drugs of this class used in obesity are commonly known as “anorectics” or “anorexigenics.” It has not been established that the primary action of such drugs in treating obesity is one of appetite suppression since other central nervous system actions, or metabolic effects, may also be involved.

12.2 Pharmacodynamics Typical actions of amphetamines include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.

12.3 Pharmacokinetics Following the administration of Phentermine, Phentermine reaches peak concentrations (Cmax) after 3 to 4.4 hours.

Drug Interactions

In a single-dose study comparing the exposures after oral administration of a combination capsule of 15 mg Phentermine and 92 mg topiramate to the exposures after oral administration of a 15 mg Phentermine capsule or a 92 mg topiramate capsule, there is no significant topiramate exposure change in the presence of Phentermine. However in the presence of topiramate, Phentermine Cmax and AUC increase 13% and 42%, respectively.

Specific Populations

Renal Impairment

Cumulative urinary excretion of phentermine under uncontrolled urinary pH conditions was 62% to 85%. Systemic exposure of phentermine may increase up to 91%, 45%, and 22% in patients with severe, moderate, and mild renal impairment, respectively [see Dosage and Administration (2.2) and Use in Specific Populations (8.6)].

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

Non-Clinical Toxicology
Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

Sulfacetamide preparations are incompatible with silver preparations.

5.1 Coadministration with Other Drug Products for Weight Loss

Phentermine is indicated only as short-term (a few weeks) monotherapy for the management of exogenous obesity. The safety and efficacy of combination therapy with phentermine and any other drug products for weight loss including prescribed drugs, over-the-counter preparations, and herbal products, or serotonergic agents such as selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. Therefore, coadministration of phentermine and these drug products is not recommended.

5.2 Primary Pulmonary Hypertension Primary Pulmonary Hypertension (PPH) – a rare, frequently fatal disease of the lungs – has been reported to occur in patients receiving a combination of phentermine with fenfluramine or dexfenfluramine. The possibility of an association between PPH and the use of phentermine alone cannot be ruled out; there have been rare cases of PPH in patients who reportedly have taken phentermine alone. The initial symptom of PPH is usually dyspnea. Other initial symptoms may include angina pectoris, syncope or lower extremity edema. Patients should be advised to report immediately any deterioration in exercise tolerance. Treatment should be discontinued in patients who develop new, unexplained symptoms of dyspnea, angina pectoris, syncope or lower extremity edema, and patients should be evaluated for the possible presence of pulmonary hypertension.

5.3 Valvular Heart Disease Serious regurgitant cardiac valvular disease, primarily affecting the mitral, aortic and/or tricuspid valves, has been reported in otherwise healthy persons who had taken a combination of phentermine with fenfluramine or dexfenfluramine for weight loss. The possible role of phentermine in the etiology of these valvulopathies has not been established and their course in individuals after the drugs are stopped is not known. The possibility of an association between valvular heart disease and the use of phentermine alone cannot be ruled out; there have been rare cases of valvular heart disease in patients who reportedly have taken phentermine alone.

5.4 Development of Tolerance, Discontinuation in Case of Tolerance When tolerance to the anorectant effect develops, the recommended dose should not be exceeded in an attempt to increase the effect; rather, the drug should be discontinued.

5.5 Effect on the Ability to Engage in Potentially Hazardous Tasks Phentermine may impair the ability of the patient to engage in potentially hazardous activities such as operating machinery or driving a motor vehicle; the patient should therefore be cautioned accordingly.

5.6 Risk of Abuse and Dependence Phentermine is related chemically and pharmacologically to amphetamine (d- and d/l-amphetamine) and other related stimulant drugs have been extensively abused. The possibility of abuse of phentermine should be kept in mind when evaluating the desirability of including a drug as part of a weight reduction program. See Drug Abuse and Dependence (9) and Overdosage (10). The least amount feasible should be prescribed or dispensed at one time in order to minimize the possibility of overdosage.

5.7 Usage with Alcohol Concomitant use of alcohol with Phentermine may result in an adverse drug reaction.

5.8 Use in Patients with Hypertension

Use caution in prescribing Phentermine for patients with even mild hypertension (risk of increase in blood pressure).

5.9 Use in Patients on Insulin or Oral Hypoglycemic Medications for Diabetes Mellitus A reduction in insulin or oral hypoglycemic medications in patients with diabetes mellitus may be required.

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

The following adverse reactions to phentermine have been identified:

Cardiovascular: Primary pulmonary hypertension and/or regurgitant cardiac valvular disease, palpitation, tachycardia, elevation of blood pressure, ischemic events.

Central Nervous System: Overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache, psychosis.

Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances.

Allergic: Urticaria.

Endocrine: Impotence, changes in libido.

Please review the manufacturer's complete drug information available from the FDA at www.fda.gov Permanent Link: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b963f7bb-fa65-4e28-81c9-282fbe70a6a6

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).