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Neupro

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Overview

What is Neupro?

NEUPRO is a transdermal system that provides continuous delivery of rotigotine, a non-ergoline dopamine agonist, for 24 hours following application to intact skin.

NEUPRO is available in six strengths as shown in Table 4.

The chemical name of rotigotine is (6S)-6-{propyl[2-(2-thienyl)ethyl]amino}-5,6,7,8-tetrahydro-1-naphthalenol. The empirical formula is CHNOS. The molecular weight is 315.48. The structural formula for rotigotine is:

The asterisk designates the chiral center.



What does Neupro look like?



What are the available doses of Neupro?

Transdermal System: 1 mg/24 hours, 2 mg/24 hours, 3 mg/24 hours, 4 mg/24 hours, 6 mg/24 hours, and 8 mg/24 hours of rotigotine. ()

What should I talk to my health care provider before I take Neupro?

Pregnancy: Based on animal data, may cause fetal harm. ()

How should I use Neupro?

NEUPRO is indicated for the treatment of Parkinson's disease.

Parkinson's disease:

Restless Legs Syndrome:

Apply once a day to the skin; press firmly in place for 30 seconds. Do not place NEUPRO on oily, irritated, or damaged skin, or where it will be rubbed by tight clothing. Do not use the same site more than once every 14 days. The prescribed dose may be achieved using single or multiple patches. ()

To discontinue treatment, reduce the dose gradually until complete withdrawal of NEUPRO. ()


What interacts with Neupro?

Sorry No Records found


What are the warnings of Neupro?

Sorry No Records found


What are the precautions of Neupro?

Sorry No Records found


What are the side effects of Neupro?

Sorry No records found


What should I look out for while using Neupro?

NEUPRO is contraindicated in patients who have demonstrated hypersensitivity to rotigotine or the components of the transdermal system.


What might happen if I take too much Neupro?


How should I store and handle Neupro?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Freezing does not adversely affect the product, but exposure to elevated temperatures should be avoided. Protect from light. Store vials in carton until used.Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Freezing does not adversely affect the product, but exposure to elevated temperatures should be avoided. Protect from light. Store vials in carton until used.Each transdermal system is packaged in a separate pouch.Each strength is available in cartons of 30 transdermal systems.Each transdermal system is packaged in a separate pouch.Each strength is available in cartons of 30 transdermal systems.


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Rotigotine is a non-ergoline dopamine agonist. The precise mechanism of action of rotigotine as a treatment for Parkinson's disease is unknown, although it is thought to be related to its ability to stimulate dopamine receptors within the caudate-putamen in the brain. The precise mechanism of action of rotigotine as a treatment for Restless Legs Syndrome is unknown but is thought to be related to its ability to stimulate dopamine receptors.

Non-Clinical Toxicology
NEUPRO is contraindicated in patients who have demonstrated hypersensitivity to rotigotine or the components of the transdermal system.

NEUPRO contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people.

The following serious adverse reactions are discussed below and elsewhere in the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

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