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carbinoxamine maleate

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Overview

What is RyVent?

Carbinoxamine maleate is a histamine-H receptor blocking agent.

Each tablet contains 6 mg carbinoxamine maleate and the following inactive ingredients: anhydrous lactose, magnesium stearate, microcrystalline cellulose, and sodium starch glycolate.

Carbinoxamine maleate is freely soluble in water. Its structure is:

2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N, N-dimethylethanamine (Z)-2-butenedioate (1:1)

CHCINO·CHO

MW= 406.86



What does RyVent look like?



What are the available doses of RyVent?

Sorry No records found.

What should I talk to my health care provider before I take RyVent?

Sorry No records found

How should I use RyVent?

Carbinoxamine maleate is effective for the symptomatic treatment of:

Seasonal and perennial allergic rhinitis.

Vasomotor rhinitis.

Allergic conjunctivitis due to inhalant allergens and foods.

Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Dermatographism.

As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

Amelioration of the severity of allergic reactions to blood or plasma.

Carbinoxamine maleate is contraindicated in children younger than 2 years of age (see ).

Carbinoxamine maleate should be taken on an empty stomach with water.

DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.

Carbinoxamine maleate dosage should be based on the severity of the condition and the response of the patient. The drug is well tolerated in adults in doses as high as 24 mg daily, in divided doses, over prolonged periods. On the other hand, some patients respond to as little as 4 mg daily.

Clinical experience suggests the following dosage schedule:

Usual Adult Dosage: 1 tablet (6 mg) 3 to 4 times daily


What interacts with RyVent?

Carbinoxamine maleate is contraindicated in children younger than 2 years of age.


Carbinoxamine maleate is contraindicated in nursing mothers.


Carbinoxamine maleate is contraindicated in patients who are hypersensitive to the drug or on monoamine oxidase inhibitor therapy (see ).



What are the warnings of RyVent?

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Deaths have been reported in children less than 2 years of age who were taking antihistamines, including carbinoxamine-containing drug products, therefore, carbinoxamine maleate is contraindicated in children younger than 2 years of age (see ).

Antihistamines should be used with considerable caution in patients with: narrow angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction.


What are the precautions of RyVent?

General

As many other antihistamines, carbinoxamine maleate has an atropine-like action and, therefore, should be used with caution in patients with: increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension.

Antihistamines such as carbinoxamine maleate should not be used to treat lower respiratory tract symptoms, including asthma.

Information for Patients

Carbinoxamine maleate may cause drowsiness; alcohol, sedatives, and tranquilizers may increase the drowsiness effect. Avoid alcoholic beverages while taking this product. Do not take this product if you are taking sedatives or tranquilizers, without first consulting your doctor. Use caution when driving a motor vehicle or operating machinery.

Drug Interactions

Monoamine oxidase inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carbinoxamine maleate has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc.).

Carcinogenesis, Mutagenesis, Impairment of Fertility

No long-term studies in animals have been performed to determine the possible effects of carbinoxamine maleate on carcinogenesis, mutagenesis, and fertility.

Pregnancy

Nursing Mothers

Because of the higher risk of antihistamines for infants generally and for newborns and prematures in particular, use of carbinoxamine maleate is contraindicated in nursing mothers (see ).

Pediatric Use

Carbinoxamine maleate is contraindicated in children younger than 2 years of age (see ).

Neonates have an increased susceptibility to anticholinergic side effects, such as CNS excitation, which may lead to convulsions.

Carbinoxamine maleate may diminish mental alertness in children. In the young child, particularly, they may produce excitation.

Geriatric Use

Carbinoxamine maleate is more likely to cause dizziness, sedation, and hypotension in elderly patients (approximately 60 years or older). Sedating drugs may also cause confusion and over sedation in the elderly. Therefore, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.


What are the side effects of RyVent?

The most frequent adverse reactions are underlined:

Body as a whole:

Cardiovascular:

Hematologic

Central nervous system:

Sedation

sleepiness

dizziness

disturbed coordination

Gastrointestinal:

Epigastric

distress

Urogenital

:

Respiratory:

Thickening of bronchial secretions

Call your doctor for medical advice about side effects. Report side effects to 1-844-700-5011.


What should I look out for while using RyVent?

Carbinoxamine maleate is contraindicated in children younger than 2 years of age.

Carbinoxamine maleate is contraindicated in nursing mothers.

Carbinoxamine maleate is contraindicated in patients who are hypersensitive to the drug or on monoamine oxidase inhibitor therapy (see ).

Deaths have been reported in children less than 2 years of age who were taking antihistamines, including carbinoxamine-containing drug products, therefore, carbinoxamine maleate is contraindicated in children younger than 2 years of age (see ).

Antihistamines should be used with considerable caution in patients with: narrow angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction.


What might happen if I take too much RyVent?


How should I store and handle RyVent?

Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16Ryvent (carbinoxamine maleate tablets USP, 6 mg) is supplied as a white, round tablet, debossed “404” on one side and “ADG” on the other side, in bottles of 100 tablets, NDC 15370-130-10 and bottles of 2 tablets as physician samples, NDC 15370-130-02.Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature].Dispense in a tight, light-resistant container with a child-resistant closure as defined in the official compendium. Rx onlyManufactured for:Carwin Pharmaceutical Associates, LLCHazlet, NJ 07730www.carwinpharma.comCode 1159B00Rev. 09/16


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Carbinoxamine maleate, an ethanolamine derivative, is an antihistamine with anticholinergic (drying) and sedative properties. Carbinoxamine appears to compete with histamine (type H1) for receptor sites on effector cells in the gastrointestinal tract, blood vessels and respiratory tract.

Non-Clinical Toxicology
Carbinoxamine maleate is contraindicated in children younger than 2 years of age.

Carbinoxamine maleate is contraindicated in nursing mothers.

Carbinoxamine maleate is contraindicated in patients who are hypersensitive to the drug or on monoamine oxidase inhibitor therapy (see ).

Deaths have been reported in children less than 2 years of age who were taking antihistamines, including carbinoxamine-containing drug products, therefore, carbinoxamine maleate is contraindicated in children younger than 2 years of age (see ).

Antihistamines should be used with considerable caution in patients with: narrow angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction, pyloroduodenal obstruction.

Monoamine oxidase inhibitors prolong and intensify the anticholinergic (drying) effects of antihistamines. Carbinoxamine maleate has additive effects with alcohol and other CNS depressants (hypnotics, sedatives, tranquilizers, etc.).

As many other antihistamines, carbinoxamine maleate has an atropine-like action and, therefore, should be used with caution in patients with: increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension.

Antihistamines such as carbinoxamine maleate should not be used to treat lower respiratory tract symptoms, including asthma.

The most frequent adverse reactions are underlined:

Body as a whole:

Cardiovascular:

Hematologic

Central nervous system:

Sedation

sleepiness

dizziness

disturbed coordination

Gastrointestinal:

Epigastric

distress

Urogenital

:

Respiratory:

Thickening of bronchial secretions

Call your doctor for medical advice about side effects. Report side effects to 1-844-700-5011.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Interactions

Interactions

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