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TOLAK

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Overview

What is TOLAK?

Tolak (fluorouracil) Cream, 4% contains 40 mg of fluorouracil per gram of white cream for topical application. It is a nucleoside metabolic inhibitor. Chemically, fluorouracil is 5-fluoro-2,4 (1H,3H)-pyrimidinedione. The molecular formula of 5-fluorouracil is CHFNO, and its molecular weight is 130.1. Its structural formula is:

Tolak Cream contains the following inactive ingredients: arlacel-165, butylated hydroxytoluene, cetyl alcohol, anhydrous citric acid, glycerin, isopropyl myristate, methyl gluceth-10, methylparaben, propylparaben, purified water, peanut oil, sodium hydroxide, stearic acid, and stearyl alcohol. Tolak Cream formulation has an alkaline pH at 8.3 to 9.2.



What does TOLAK look like?



What are the available doses of TOLAK?

Cream: 40 mg of fluorouracil per gram of cream (4%) ().

What should I talk to my health care provider before I take TOLAK?

How should I use TOLAK?

Tolak (fluorouracil) Cream is indicated for the topical treatment of actinic keratosis lesions of the face, ears, and/or scalp.

Prior to application of Tolak Cream, wash, rinse, and dry the treatment areas. Apply Tolak Cream once daily in an amount sufficient to cover the lesions of the face, ears, and/or scalp with a thin film, using the fingertips to gently massage the medication uniformly into the skin. Apply Tolak Cream for a period of 4 weeks as tolerated. Thoroughly wash hands following Tolak Cream application.

Tolak Cream is for topical use only. Do not apply to eyes, nose, mouth or mucous membranes. Not for ophthalmic, oral or intravaginal use.


What interacts with TOLAK?

Sorry No Records found


What are the warnings of TOLAK?

Sorry No Records found


What are the precautions of TOLAK?

Sorry No Records found


What are the side effects of TOLAK?

Sorry No records found


What should I look out for while using TOLAK?

Tolak Cream is contraindicated:


What might happen if I take too much TOLAK?

Sorry No Records found


How should I store and handle TOLAK?

Store at 25°C (77°F), with excursion permitted from 15°C to 30°C (59°F - 86°F) [See USP Controlled Room Temperature]. Do not freeze. Product: 50436-3173NDC: 50436-3173-2 14 TABLET in a BOTTLENDC: 50436-3173-3 28 TABLET in a BOTTLENDC: 50436-3173-1 7 TABLET in a BOTTLENDC: 50436-3173-4 21 TABLET in a BOTTLEProduct: 50436-3173NDC: 50436-3173-2 14 TABLET in a BOTTLENDC: 50436-3173-3 28 TABLET in a BOTTLENDC: 50436-3173-1 7 TABLET in a BOTTLENDC: 50436-3173-4 21 TABLET in a BOTTLEProduct: 50436-3173NDC: 50436-3173-2 14 TABLET in a BOTTLENDC: 50436-3173-3 28 TABLET in a BOTTLENDC: 50436-3173-1 7 TABLET in a BOTTLENDC: 50436-3173-4 21 TABLET in a BOTTLEProduct: 50436-3173NDC: 50436-3173-2 14 TABLET in a BOTTLENDC: 50436-3173-3 28 TABLET in a BOTTLENDC: 50436-3173-1 7 TABLET in a BOTTLENDC: 50436-3173-4 21 TABLET in a BOTTLEProduct: 50436-3173NDC: 50436-3173-2 14 TABLET in a BOTTLENDC: 50436-3173-3 28 TABLET in a BOTTLENDC: 50436-3173-1 7 TABLET in a BOTTLENDC: 50436-3173-4 21 TABLET in a BOTTLE


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of deoxyuridylic acid to thymidylic acid. In this manner, fluorouracil interferes with the synthesis of DNA and to a lesser extent inhibits the formation of RNA. Since DNA and RNA are essential for cell division and growth, the effect of fluorouracil may be to create a thymine deficiency that provokes unbalanced growth and death of the cell. The effects of DNA and RNA deprivation are most marked on those cells that grow more rapidly and take up fluorouracil at a more rapid rate.

Non-Clinical Toxicology
Tolak Cream is contraindicated:

The concomitant administration of methenamine hippurate and sulfamethizole or sulfathiazole is liable to result in the formation of a precipitate in the urine.

Application site reactions (erythema, scaling/dryness, edema, crusting, erosions, stinging/burning, and pruritus) were observed in almost all patients during treatment of actinic keratosis on the face, ears, and/or scalp with topical fluorouracil . In the clinical trials of Tolak Cream, application site irritation returned to baseline (pre-treatment) levels within 4 weeks after discontinuing treatment.

Do not apply Tolak Cream directly into eyes, nose, mouth, or other mucous membranes because irritation, local inflammation and ulceration can occur.

The following serious adverse reactions are discussed in more detail in other sections of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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