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Emcyt
Overview
What is Emcyt?
Estramustine phosphate sodium, an antineoplastic agent, is an off-white powder readily soluble in water. EMCYT Capsules are white and opaque, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate, for oral administration. Each capsule also contains magnesium stearate, silicon dioxide, sodium lauryl sulfate, and talc. Gelatin capsule shells contain the following pigment: titanium dioxide.
Chemically, estramustine phosphate sodium is estra-1,3,5(10)-triene-3,17-diol(17β)-,3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate. It is also referred to as estradiol 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt, monohydrate. Estramustine phosphate sodium has an empiric formula of CHClNNaOP•HO, a calculated molecular weight of 582.4, and the following structural formula:
What does Emcyt look like?
What are the available doses of Emcyt?
Sorry No records found.
What should I talk to my health care provider before I take Emcyt?
Sorry No records found
How should I use Emcyt?
EMCYT Capsules are indicated in the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate.
The recommended daily dose is 14 mg per kg of body weight (ie, one 140 mg capsule for each 10 kg or 22 lb of body weight), given in 3 or 4 divided doses. Most patients in studies in the United States have been treated at a dosage range of 10 to 16 mg per kg per day.
Patients should be instructed to take EMCYT Capsules at least 1 hour before or 2 hours after meals. EMCYT should be swallowed with water. Milk, milk products, and calcium-rich foods or drugs (such as calcium-containing antacids) must not be taken simultaneously with EMCYT.
Patients should be treated for 30 to 90 days before the physician determines the possible benefits of continued therapy. Therapy should be continued as long as the favorable response lasts. Some patients have been maintained on therapy for more than 3 years at doses ranging from 10 to 16 mg per kg of body weight per day.
Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published. There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.
What interacts with Emcyt?
- EMCYT Capsules should not be used in patients with any of the following conditions:
- 1)
- 2)
What are the warnings of Emcyt?
Array
It has been shown that there is an increased risk of thrombosis, including fatal and nonfatal myocardial infarction, in men receiving estrogens for prostatic cancer. EMCYT Capsules should be used with caution in patients with a history of thrombophlebitis, thrombosis, or thromboembolic disorders, especially if they were associated with estrogen therapy. Caution should also be used in patients with cerebral vascular or coronary artery disease.
Glucose Tolerance—Because glucose tolerance may be decreased, diabetic patients should be carefully observed while receiving EMCYT.
Elevated Blood Pressure—Because hypertension may occur, blood pressure should be monitored periodically.
What are the precautions of Emcyt?
General
Fluid Retention. Exacerbation of preexisting or incipient peripheral edema or congestive heart disease has been seen in some patients receiving therapy with EMCYT Capsules. Other conditions which might be influenced by fluid retention, such as epilepsy, migraine, or renal dysfunction, require careful observation.
EMCYT may be poorly metabolized in patients with impaired liver function and should be administered with caution in such patients.
Because EMCYT may influence the metabolism of calcium and phosphorus, it should be used with caution in patients with metabolic bone diseases that are associated with hypercalcemia or in patients with renal insufficiency. Patients with prostate cancer and osteoblastic metastases are at risk for hypocalcemia and should have calcium levels closely monitored.
Gynecomastia and impotence are known estrogenic effects.
Allergic reactions and angioedema at times involving the airway have been reported.
Information for the Patient
Because of the possibility of mutagenic effects, patients should be advised to use contraceptive measures.
Laboratory Tests
Certain endocrine and liver function tests may be affected by estrogen-containing drugs. EMCYT may depress testosterone levels. Abnormalities of hepatic enzymes and of bilirubin have occurred in patients receiving EMCYT. Such tests should be done at appropriate intervals during therapy and repeated after the drug has been withdrawn for two months.
Food/Drug Interaction
Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.
Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term continuous administration of estrogens in certain animal species increases the frequency of carcinomas of the breast and liver. Compounds structurally similar to EMCYT are carcinogenic in mice. Carcinogenic studies of EMCYT have not been conducted in man. Although testing by the Ames method failed to demonstrate mutagenicity for estramustine phosphate sodium, it is known that both estradiol and nitrogen mustard are mutagenic. For this reason and because some patients who had been impotent while on estrogen therapy have regained potency while taking EMCYT, the patient should be advised to use contraceptive measures.
What are the side effects of Emcyt?
In a randomized, double-blind trial comparing therapy with EMCYT Capsules in 93 patients (11.5 to 15.9 mg/kg/day) or diethylstilbestrol (DES) in 93 patients (3.0 mg/day), the following adverse effects were reported:
| EMCYTn=93 | DESn=93 | |
|---|---|---|
| CARDIOVASCULAR-RESPIRATORY | ||
| Cardiac Arrest | 0 | 2 |
| Cerebrovascular Accident | 2 | 0 |
| Myocardial Infarction | 3 | 1 |
| Thrombophlebitis | 3 | 7 |
| Pulmonary Emboli | 2 | 5 |
| Congestive Heart Failure | 3 | 2 |
| Edema | 19 | 17 |
| Dyspnea | 11 | 3 |
| Leg Cramps | 8 | 11 |
| Upper Respiratory Discharge | 1 | 1 |
| Hoarseness | 1 | 0 |
| GASTROINTESTINAL | ||
| Nausea | 15 | 8 |
| Diarrhea | 12 | 11 |
| Minor Gastrointestinal Upset | 11 | 6 |
| Anorexia | 4 | 3 |
| Flatulence | 2 | 0 |
| Vomiting | 1 | 1 |
| Gastrointestinal Bleeding | 1 | 0 |
| Burning Throat | 1 | 0 |
| Thirst | 1 | 0 |
| INTEGUMENTARY | ||
| Rash | 1 | 4 |
| Pruritus | 2 | 2 |
| Dry Skin | 2 | 0 |
| Pigment Changes | 0 | 3 |
| Easy Bruising | 3 | 0 |
| Flushing | 1 | 0 |
| Night Sweats | 0 | 1 |
| Fingertip—Peeling Skin | 1 | 0 |
| Thinning Hair | 1 | 1 |
| BREAST CHANGES | ||
| Tenderness | 66 | 64 |
| Enlargement | ||
| Mild | 60 | 54 |
| Moderate | 10 | 16 |
| Marked | 0 | 5 |
| MISCELLANEOUS | ||
| Lethargy Alone | 4 | 3 |
| Depression | 0 | 2 |
| Emotional Lability | 2 | 0 |
| Insomnia | 3 | 0 |
| Headache | 1 | 1 |
| Anxiety | 1 | 0 |
| Chest Pain | 1 | 1 |
| Hot Flashes | 0 | 1 |
| Pain in Eyes | 0 | 1 |
| Tearing of Eyes | 1 | 1 |
| Tinnitus | 0 | 1 |
| LABORATORY ABNORMALITIES | ||
| Hematologic | ||
| Leukopenia | 4 | 2 |
| Thrombopenia | 1 | 2 |
| Hepatic | ||
| Bilirubin Alone | 1 | 5 |
| Bilirubin and LDH | 0 | 1 |
| Bilirubin and SGOT | 2 | 1 |
| Bilirubin, LDH and SGOT | 2 | 0 |
| LDH and/or SGOT | 31 | 28 |
| Miscellaneous | ||
| Hypercalcemia—Transient | 0 | 1 |
What should I look out for while using Emcyt?
EMCYT Capsules should not be used in patients with any of the following conditions:
It has been shown that there is an increased risk of thrombosis, including fatal and nonfatal myocardial infarction, in men receiving estrogens for prostatic cancer. EMCYT Capsules should be used with caution in patients with a history of thrombophlebitis, thrombosis, or thromboembolic disorders, especially if they were associated with estrogen therapy. Caution should also be used in patients with cerebral vascular or coronary artery disease.
Glucose Tolerance—Because glucose tolerance may be decreased, diabetic patients should be carefully observed while receiving EMCYT.
Elevated Blood Pressure—Because hypertension may occur, blood pressure should be monitored periodically.
What might happen if I take too much Emcyt?
Although there has been no experience with overdosage to date, it is reasonable to expect that such episodes may produce pronounced manifestations of the known adverse reactions. In the event of overdosage, the gastric contents should be evacuated by gastric lavage and symptomatic therapy should be initiated. Hematologic and hepatic parameters should be monitored for at least 6 weeks after overdosage of EMCYT Capsules.
How should I store and handle Emcyt?
Protect polymer bottles of OMNIPAQUE from strong daylight and direct exposure to sunlight. Do not freeze. OMNIPAQUE should be stored at controlled room temperature, 20°-25°C (68°- 77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature].OMNIPAQUE Injection in all presentations may be stored in a contrast media warmer for up to one month at 37°C (98.6°F).SPECIAL HANDLING AND STORAGE FOR POLYMER BOTTLES ONLY: DO NOT USE IF TAMPER-EVIDENT RING IS BROKEN OR MISSING.Protect polymer bottles of OMNIPAQUE from strong daylight and direct exposure to sunlight. Do not freeze. OMNIPAQUE should be stored at controlled room temperature, 20°-25°C (68°- 77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature].OMNIPAQUE Injection in all presentations may be stored in a contrast media warmer for up to one month at 37°C (98.6°F).SPECIAL HANDLING AND STORAGE FOR POLYMER BOTTLES ONLY: DO NOT USE IF TAMPER-EVIDENT RING IS BROKEN OR MISSING.Protect polymer bottles of OMNIPAQUE from strong daylight and direct exposure to sunlight. Do not freeze. OMNIPAQUE should be stored at controlled room temperature, 20°-25°C (68°- 77°F); excursions permitted to 15°-30°C (59°-86°F) [see USP Controlled Room Temperature].OMNIPAQUE Injection in all presentations may be stored in a contrast media warmer for up to one month at 37°C (98.6°F).SPECIAL HANDLING AND STORAGE FOR POLYMER BOTTLES ONLY: DO NOT USE IF TAMPER-EVIDENT RING IS BROKEN OR MISSING.White opaque capsules, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate—bottle of 100 (NDC 0013-0132-02).NOTEEMCYT Capsules should be stored in the refrigerator at 36° to 46°F (2° to 8°C).White opaque capsules, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate—bottle of 100 (NDC 0013-0132-02).NOTEEMCYT Capsules should be stored in the refrigerator at 36° to 46°F (2° to 8°C).White opaque capsules, each containing estramustine phosphate sodium as the disodium salt monohydrate equivalent to 140 mg estramustine phosphate—bottle of 100 (NDC 0013-0132-02).NOTEEMCYT Capsules should be stored in the refrigerator at 36° to 46°F (2° to 8°C).
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Estramustine phosphate (Figure 1) is a molecule combining estradiol and nornitrogen mustard by a carbamate link. The molecule is phosphorylated to make it water soluble.
Estramustine phosphate taken orally is readily dephosphorylated during absorption, and the major metabolites in plasma are estramustine (Figure 2), the estrone analog (Figure 3), estradiol, and estrone.
Prolonged treatment with estramustine phosphate produces elevated total plasma concentrations of estradiol that fall within ranges similar to the elevated estradiol levels found in prostatic cancer patients given conventional estradiol therapy. Estrogenic effects, as demonstrated by changes in circulating levels of steroids and pituitary hormones, are similar in patients treated with either estramustine phosphate or conventional estradiol.
The metabolic urinary patterns of the estradiol moiety of estramustine phosphate and estradiol itself are very similar, although the metabolites derived from estramustine phosphate are excreted at a slower rate.
Non-Clinical Toxicology
EMCYT Capsules should not be used in patients with any of the following conditions:It has been shown that there is an increased risk of thrombosis, including fatal and nonfatal myocardial infarction, in men receiving estrogens for prostatic cancer. EMCYT Capsules should be used with caution in patients with a history of thrombophlebitis, thrombosis, or thromboembolic disorders, especially if they were associated with estrogen therapy. Caution should also be used in patients with cerebral vascular or coronary artery disease.
Glucose Tolerance—Because glucose tolerance may be decreased, diabetic patients should be carefully observed while receiving EMCYT.
Elevated Blood Pressure—Because hypertension may occur, blood pressure should be monitored periodically.
Milk, milk products, and calcium-rich foods or drugs may impair the absorption of EMCYT.
Fluid Retention. Exacerbation of preexisting or incipient peripheral edema or congestive heart disease has been seen in some patients receiving therapy with EMCYT Capsules. Other conditions which might be influenced by fluid retention, such as epilepsy, migraine, or renal dysfunction, require careful observation.
EMCYT may be poorly metabolized in patients with impaired liver function and should be administered with caution in such patients.
Because EMCYT may influence the metabolism of calcium and phosphorus, it should be used with caution in patients with metabolic bone diseases that are associated with hypercalcemia or in patients with renal insufficiency. Patients with prostate cancer and osteoblastic metastases are at risk for hypocalcemia and should have calcium levels closely monitored.
Gynecomastia and impotence are known estrogenic effects.
Allergic reactions and angioedema at times involving the airway have been reported.
In a randomized, double-blind trial comparing therapy with EMCYT Capsules in 93 patients (11.5 to 15.9 mg/kg/day) or diethylstilbestrol (DES) in 93 patients (3.0 mg/day), the following adverse effects were reported:
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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