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eletriptan hydrobromide

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Overview

What is eletriptan hydrobromide?

Eletriptan hydrobromide tablets contain eletriptan hydrobromide, which is a selective 5-hydroxytryptamine 1B/1D (5-HT1B/1D) receptor agonist. Eletriptan hydrobromide is chemically designated as (R)-3-[(1-Methyl-2-pyrrolidinyl)methyl]-5-[2-(phenylsulfonyl)ethyl]-1H-indole monohydrobromide, and it has the following chemical structure:

The molecular formula is CHNOS . HBr, representing a molecular weight of 463.43. Eletriptan hydrobromide is a cream to pale brown powder that is readily soluble in water.

Each eletriptan hydrobromide tablet for oral administration contains 24.2 or 48.5 mg of eletriptan hydrobromide equivalent to 20 mg or 40 mg of eletriptan, respectively. Each tablet also contains the inactive ingredients microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, titanium dioxide, hypromellose, triacetin, FD&C Yellow No. 6 aluminum lake.



What does eletriptan hydrobromide look like?



What are the available doses of eletriptan hydrobromide?

Tablets: 20 mg and 40 mg

What should I talk to my health care provider before I take eletriptan hydrobromide?

Pregnancy: based on animal data, may cause fetal harm ()

How should I use eletriptan hydrobromide?

Eletriptan hydrobromide tablets are indicated for the acute treatment of migraine with or without aura in adults.

Limitations of Use:

The maximum recommended single dose is 40 mg. In controlled clinical trials, single doses of 20 mg and 40 mg were effective for the acute treatment of migraine in adults. A greater proportion of patients had a response following a 40 mg dose than following a 20 mg dose .

If the migraine has not resolved by 2 hours after taking eletriptan hydrobromide tablets, or returns after transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose should not exceed 80 mg.   The safety of treating an average of more than 3 migraine attacks in a 30-day period has not been established.


What interacts with eletriptan hydrobromide?

Sorry No Records found


What are the warnings of eletriptan hydrobromide?

Sorry No Records found


What are the precautions of eletriptan hydrobromide?

Sorry No Records found


What are the side effects of eletriptan hydrobromide?

Sorry No records found


What should I look out for while using eletriptan hydrobromide?

Eletriptan hydrobromide tablets are contraindicated in patients with:


What might happen if I take too much eletriptan hydrobromide?

The elimination half-life of eletriptan is about 4 hours , therefore monitoring of patients after overdose with eletriptan should continue for at least 20 hours or longer while symptoms or signs persist.

There is no specific antidote to eletriptan.

It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentration of eletriptan.


How should I store and handle eletriptan hydrobromide?

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].Eletriptan hydrobromide tablets containing 20 mg or 40 mg eletriptan (base) as the hydrobromide salt. Eletriptan hydrobromide tabletsare orange, round, biconvex, film-coated tablets with appropriate debossing. They are supplied in the following strengths and package configurations: Eletriptan hydrobromide tabletsStore at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Eletriptan hydrobromide tablets containing 20 mg or 40 mg eletriptan (base) as the hydrobromide salt. Eletriptan hydrobromide tabletsare orange, round, biconvex, film-coated tablets with appropriate debossing. They are supplied in the following strengths and package configurations: Eletriptan hydrobromide tabletsStore at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Eletriptan hydrobromide tablets containing 20 mg or 40 mg eletriptan (base) as the hydrobromide salt. Eletriptan hydrobromide tabletsare orange, round, biconvex, film-coated tablets with appropriate debossing. They are supplied in the following strengths and package configurations: Eletriptan hydrobromide tabletsStore at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].Eletriptan hydrobromide tablets containing 20 mg or 40 mg eletriptan (base) as the hydrobromide salt. Eletriptan hydrobromide tabletsare orange, round, biconvex, film-coated tablets with appropriate debossing. They are supplied in the following strengths and package configurations: Eletriptan hydrobromide tabletsStore at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Eletriptan binds with high affinity to 5-HT, 5-HT and 5-HT receptors, has modest affinity for 5-HT, 5-HT, 5-HT and 5-HT receptors.

Migraines are likely due to local cranial vasodilatation and/or to the release of sensory neuropeptides (vasoactive intestinal peptide, substance P and calcitonin gene-related peptide) through nerve endings in the trigeminal system. The therapeutic activity of eletriptan hydrobromide tablets for the treatment of migraine headache is thought to be due to the agonist effects at the 5-HTreceptors on intracranial blood vessels (including the arterio-venous anastomoses) and sensory nerves of the trigeminal system which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.

Non-Clinical Toxicology
Eletriptan hydrobromide tablets are contraindicated in patients with:

Eletriptan hydrobromide tablets should only be used where a clear diagnosis of migraine has been established. 

The following adverse reactions are described elsewhere in other sections of the prescribing information:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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