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Caspofungin Acetate

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Overview

What is Caspofungin Acetate?

Caspofungin acetate for injection is a sterile, lyophilized product for intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of Caspofungin acetate is an echinocandin antifungal that inhibits the synthesis of β (1,3)-D-glucan, an integral component of the fungal cell wall.

Caspofungin acetate is 1-[(4,5)-5-[(2-aminoethyl)amino]- -(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3)-3-hydroxy-L-ornithine] pneumocandin B diacetate (salt). Caspofungin acetate for injection 50 mg vial contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate. Caspofungin acetate for injection 50 mg vial also contains 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate for injection 70 mg vial contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate. Caspofungin acetate for injection 70 mg vial also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is CHNO•2CHO and the formula weight is 1213.42. The structural formula is:



What does Caspofungin Acetate look like?



What are the available doses of Caspofungin Acetate?

Caspofungin Acetate for Injection 50 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with an aluminum seal and a plastic cap. Caspofungin acetate for injection 50 mg vial contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate.

Caspofungin Acetate for Injection 70 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with an aluminum seal and a plastic cap. Caspofungin acetate for injection 70 mg vial contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate.

What should I talk to my health care provider before I take Caspofungin Acetate?

How should I use Caspofungin Acetate?

Caspofungin acetate for injection is indicated as empirical therapy for presumed fungal infections in febrile, neutropenic adult and pediatric patients (3 months of age and older)

Administer caspofungin acetate for injection by slow intravenous (IV) infusion over approximately 1 hour. Do not administer caspofungin acetate for injection by IV bolus administration.


What interacts with Caspofungin Acetate?

Sorry No Records found


What are the warnings of Caspofungin Acetate?

Sorry No Records found


What are the precautions of Caspofungin Acetate?

Sorry No Records found


What are the side effects of Caspofungin Acetate?

Sorry No records found


What should I look out for while using Caspofungin Acetate?

Caspofungin is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product


What might happen if I take too much Caspofungin Acetate?

In 6 healthy subjects who received a single 210 mg dose, no significant adverse reactions were reported. Multiple doses above 150 mg daily have not been studied. Caspofungin is not dialyzable.

In clinical trials, one pediatric patient (16 years of age) unintentionally received a single dose of caspofungin of 113 mg (on Day 1), followed by 80 mg daily for an additional 7 days. No clinically significant adverse reactions were reported.


How should I store and handle Caspofungin Acetate?

Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F) [See USP Controlled Room Temperature]. Keep tightly closed (protect from moisture). Protect from light. Caspofungin Acetate for Injection is supplied as follows: Caspofungin Acetate for Injection is a lyophilized white to off-white powder/cake for intravenous infusion in a vial with an aluminum flip off seal and plastic cap. The lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Caspofungin Acetate for Injection is supplied as follows: Caspofungin Acetate for Injection is a lyophilized white to off-white powder/cake for intravenous infusion in a vial with an aluminum flip off seal and plastic cap. The lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).Caspofungin Acetate for Injection is supplied as follows: Caspofungin Acetate for Injection is a lyophilized white to off-white powder/cake for intravenous infusion in a vial with an aluminum flip off seal and plastic cap. The lyophilized vials should be stored refrigerated at 2° to 8°C (36° to 46°F).


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Caspofungin is an echinocandin antifungal drug

Non-Clinical Toxicology
Caspofungin is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product

Antipsychotic drugs such as phenothiazines or haloperidol; tricyclic antidepressants (see ).

[see Adverse Reactions ()]

The following serious adverse reactions are discussed in detail in another section of the labeling:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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