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Pyridium
Overview
What is Pyridium?
Pyridium ® (Phenazopyridine Hydrochloride) is light or dark red to dark violet, odorless, slightly bitter, crystalline powder. It has a specific local analgesic effect in the urinary tract, promptly relieving burning and pain. It has the following structural formula:
What does Pyridium look like?
What are the available doses of Pyridium?
Sorry No records found.
What should I talk to my health care provider before I take Pyridium?
Sorry No records found
How should I use Pyridium?
Pyridium is indicated for the symptomatic relief of pain, burning, urgency, frequency, and other discomforts arising from irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, endoscopic procedures, or the passage of sounds or catheters. The use of Phenazopyridine HCl for relief of symptoms should not delay definitive diagnosis and treatment of causative conditions. Because it provides only symptomatic relief, prompt appropriate treatment of the cause of pain must be instituted and Phenazopyridine HCl should be discontinued when symptoms are controlled.
The analgesic action may reduce or eliminate the need for systemic analgesics or narcotics. It is, however, compatible with antibacterial therapy and can help to relieve pain and discomfort during the interval before antibacterial therapy controls the infection. Treatment of a urinary tract infection with Phenazopyridine HCl should not exceed two days because there is a lack of evidence that the combined administration of Phenazopyridine HCl and an antibacterial provides greater benefit than administration of the antibacterial alone after two days. (See
section.)
100 mg Tablets: Average adult dosage is two tablets 3 times a day after meals.
200 mg Tablets: Average adult dosage is one tablet 3 times a day after meals.
When used concomitantly with an antibacterial agent for the treatment of a urinary tract infection, the administration of Phenazopyridine HCl should not exceed 2 days.
What interacts with Pyridium?
Phenazopyridine HCl should not be used in patients who have previously exhibited sensitivity to it. The use of Phenazopyridine HCl is contraindicated in patients with renal insufficiency.
What are the warnings of Pyridium?
Sorry No Records found
What are the precautions of Pyridium?
precautions
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General:
A yellowish tinge of the skin or sclera may indicate accumulation due to impaired renal excretion and the need to discontinue therapy. The decline in renal function associated with advanced age should be kept in mind.
NOTE:
Laboratory Test Interaction:
Due to its properties as an azo dye, Phenazopyridine HCl may interfere with urinalysis based on spectrometry or color reactions.
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Carcinogenesis, Mutagenesis, Impairment of Fertility
Long-term administration of Phenazopyridine HCl has induced neoplasia in rats (large intestine) and mice (liver).
Although no association between Phenazopyridine HCl and human neoplasia has been reported, adequate epidemiological studies along these lines have not been conducted.
Pregnancy Category B:
Reproduction studies have been performed in rats at doses up to 50 mg/kg/day and have revealed no evidence of impaired fertility or harm to the fetus due to Phenazopyridine HCl. There are, however, no adequate and well controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
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Nursing mothers:
No information is available on the appearance of Phenazopyridine HCl, or its metabolites in human milk.
What are the side effects of Pyridium?
Headache, rash, pruritus and occasional gastrointestinal disturbance. At anaphylactoid-like reaction has been described. Methemoglobinemia, hemolytic anemia, renal and hepatic toxicity have been reported, usually at overdosage levels (see
section).
What should I look out for while using Pyridium?
Phenazopyridine HCl should not be used in patients who have previously exhibited sensitivity to it. The use of Phenazopyridine HCl is contraindicated in patients with renal insufficiency.
What might happen if I take too much Pyridium?
Exceeding the recommended dose in patients with good renal function or administering the usual dose to patients with impaired renal function (common in elderly patients) may lead to increased serum levels and toxic reactions. Methemoglobinemia generally follows a massive, acute overdose. Methylene blue, 1 to 2 mg/kg/body weight intravenously or ascorbic acid 100 to 200 mg given orally should cause prompt reduction of the methemoglobinemia and disappearance of the cyanosis which is an aid in diagnosis. Oxidative Heinz body hemolytic anemia may also occur, and “bite cells” (degmacytes) may be present in a chronic overdosage situation. Red blood cell G-6-PD deficiency may predispose to hemolysis. Renal and hepatic impairment and occasional failure, usually due to hypersensitivity, may also occur.
How should I store and handle Pyridium?
100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01100 mg Tablets: Supplied in bottles of 100 (NDC 60846-501-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "1" on one side and plain on the other.200 mg Tablets: Supplied in bottles of 1-- (NDC 60846-502-01) counts.Appearance: Deep brown to maroon colored, round, film coated tablets debossed "PY" above "2" on one side and plain on the other.DISPENSESTOREManufactured for:Gemini Laboratories, LLCBridgewater, NJ 08807Rev. 05-2015-01
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Phenazopyridine HCl is excreted in the urine where it exerts a topical analgesic effect on the mucosa of the urinary tract. This action helps to relieve pain, burning, urgency and frequency. The precise mechanism of action is not known.
The pharmacokinetic properties of Phenazopyridine HCl have not been determined. Phenazopyridine HCl is rapidly excreted by the kidneys, with as much as 66% of an oral dose being excreted unchanged in the urine.
Non-Clinical Toxicology
Phenazopyridine HCl should not be used in patients who have previously exhibited sensitivity to it. The use of Phenazopyridine HCl is contraindicated in patients with renal insufficiency.Reduced efficacy and increased incidence of breakthrough bleeding and menstrual irregularities have been associated with concomitant use of rifampin. A similar association though less marked, has been suggested with barbiturates, phenylbutazone, phenytoin sodium, and possibly with griseofulvin, ampicillin and tetracyclines.
precautions
Headache, rash, pruritus and occasional gastrointestinal disturbance. At anaphylactoid-like reaction has been described. Methemoglobinemia, hemolytic anemia, renal and hepatic toxicity have been reported, usually at overdosage levels (see section).
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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