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Actos

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Overview

What is Actos?

ACTOS (pioglitazone hydrochloride) is an oral antidiabetic agent that acts primarily by decreasing insulin resistance. ACTOS is used in the management of type 2 diabetes mellitus (also known as non-insulin-dependent diabetes mellitus [NIDDM] or adult-onset diabetes). Pharmacological studies indicate that ACTOS improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. ACTOS improves glycemic control while reducing circulating insulin levels.

      Pioglitazone [(±)-5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-] thiazolidinedione monohydrochloride belongs to a different chemical class and has a different pharmacological action than the sulfonylureas, metformin, or the α-glucosidase inhibitors. The molecule contains one asymmetric carbon, and the compound is synthesized and used as the racemic mixture. The two enantiomers of pioglitazone interconvert . No differences were found in the pharmacologic activity between the two enantiomers. The structural formula is as shown:

      Pioglitazone hydrochloride is an odorless white crystalline powder that has a molecular formula of CHNOS•HCl and a molecular weight of 392.90 daltons. It is soluble in N,N-dimethylformamide, slightly soluble in anhydrous ethanol, very slightly soluble in acetone and acetonitrile, practically insoluble in water, and insoluble in ether.

      ACTOS is available as a tablet for oral administration containing 15 mg, 30 mg, or 45 mg of pioglitazone (as the base) formulated with the following excipients: lactose monohydrate NF, hydroxypropylcellulose NF, carboxymethylcellulose calcium NF, and magnesium stearate NF.



What does Actos look like?



What are the available doses of Actos?

Sorry No records found.

What should I talk to my health care provider before I take Actos?

Sorry No records found

How should I use Actos?

ACTOS is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

ACTOS should be taken once daily without regard to meals.

      The management of antidiabetic therapy should be individualized. Ideally, the response to therapy should be evaluated using HbA which is a better indicator of long-term glycemic control than FPG alone. HbA reflects glycemia over the past two to three months. In clinical use, it is recommended that patients be treated with ACTOS for a period of time adequate to evaluate change in HbA (three months) unless glycemic control deteriorates. After initiation of ACTOS or with dose increase, patients should be carefully monitored for adverse events related to fluid retention (see and ).


What interacts with Actos?

Sorry No Records found


What are the warnings of Actos?

Sorry No Records found


What are the precautions of Actos?

Sorry No Records found


What are the side effects of Actos?

Sorry No records found


What should I look out for while using Actos?

Initiation of ACTOS in patients with established New York Heart Association (NYHA) Class III or IV heart failure is contraindicated (see ).

      ACTOS is contraindicated in patients with known hypersensitivity to this product or any of its components.


What might happen if I take too much Actos?

During controlled clinical trials, one case of overdose with ACTOS was reported. A male patient took 120 mg per day for four days, then 180 mg per day for seven days. The patient denied any clinical symptoms during this period.

      In the event of overdosage, appropriate supportive treatment should be initiated according to patient’s clinical signs and symptoms.


How should I store and handle Actos?

ACTOS is available in 15 mg, 30 mg, and 45 mg tablets as follows:15 mg Tablet: white to off-white, round, convex, non-scored tablet with “ACTOS” on one side, and “15” on the other, available in:NDC 21695-147-15 Bottles of 1530 mg Tablet: white to off-white, round, flat, non-scored tablet with “ACTOS” on one side, and “30” on the other, available in:NDC 21695-148-15 Bottles of 15ACTOS is available in 15 mg, 30 mg, and 45 mg tablets as follows:15 mg Tablet: white to off-white, round, convex, non-scored tablet with “ACTOS” on one side, and “15” on the other, available in:NDC 21695-147-15 Bottles of 1530 mg Tablet: white to off-white, round, flat, non-scored tablet with “ACTOS” on one side, and “30” on the other, available in:NDC 21695-148-15 Bottles of 15ACTOS is available in 15 mg, 30 mg, and 45 mg tablets as follows:15 mg Tablet: white to off-white, round, convex, non-scored tablet with “ACTOS” on one side, and “15” on the other, available in:NDC 21695-147-15 Bottles of 1530 mg Tablet: white to off-white, round, flat, non-scored tablet with “ACTOS” on one side, and “30” on the other, available in:NDC 21695-148-15 Bottles of 15ACTOS is available in 15 mg, 30 mg, and 45 mg tablets as follows:15 mg Tablet: white to off-white, round, convex, non-scored tablet with “ACTOS” on one side, and “15” on the other, available in:NDC 21695-147-15 Bottles of 1530 mg Tablet: white to off-white, round, flat, non-scored tablet with “ACTOS” on one side, and “30” on the other, available in:NDC 21695-148-15 Bottles of 15ACTOS is available in 15 mg, 30 mg, and 45 mg tablets as follows:15 mg Tablet: white to off-white, round, convex, non-scored tablet with “ACTOS” on one side, and “15” on the other, available in:NDC 21695-147-15 Bottles of 1530 mg Tablet: white to off-white, round, flat, non-scored tablet with “ACTOS” on one side, and “30” on the other, available in:NDC 21695-148-15 Bottles of 15