Disclaimer:

Medidex is not a provider of medical services and all information is provided for the convenience of the user. No medical decisions should be made based on the information provided on this website without first consulting a licensed healthcare provider.This website is intended for persons 18 years or older. No person under 18 should consult this website without the permission of a parent or guardian.

ephedrine sulfate

×

Overview

What is Akovaz?

Ephedrine is an alpha- and beta-adrenergic agonist and a norepinephrine-releasing agent. AKOVAZ (ephedrine sulfate injection) is a clear, colorless, sterile solution for intravenous injection. It must be diluted before intravenous administration. The chemical name of ephedrine sulfate is (1R,2S)-(-)-2-methylamine-1-phenylpropan-1-ol sulfate, and the molecular weight is 428.5 g/mol. Its structural formula is depicted below:

Ephedrine sulfate is freely soluble in water and ethanol, very slighly soluble in chloroform, and practically insoluble in ether. Each mL contains ephedrine sulfate 50 mg (equivalent to 38 mg ephedrine base) in water for injection. The pH is adjusted with sodium hydroxide and/or glacial acetic acid if necesssary. The pH range is 4.5 to 7.0.



What does Akovaz look like?



What are the available doses of Akovaz?

Injection: 50 mg/mL ephedrine sulfate in single-use vial ()

What should I talk to my health care provider before I take Akovaz?

How should I use Akovaz?

AKOVAZ (ephedrine sulfate injection) is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia.

AKOVAZ (ephedrine sulfate injection) must be diluted before administration as an intravenous bolus to achieve the desired concentration. Dilute with normal saline or 5% dextrose in water.

Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit.


What interacts with Akovaz?

Sorry No Records found


What are the warnings of Akovaz?

Sorry No Records found


What are the precautions of Akovaz?

Sorry No Records found


What are the side effects of Akovaz?

Sorry No records found


What should I look out for while using Akovaz?

None


What might happen if I take too much Akovaz?

Overdose of ephedrine can cause a rapid rise in blood pressure. In the case of an overdose, careful monitoring of blood pressure is recommended. If blood pressure continues to rise to an unacceptable level, parenteral antihypertensive agents can be administered at the discretion of the clinician.


How should I store and handle Akovaz?

AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017AKOVAZ (ephedrine sulfate injection), 50 mg/mL, is supplied as follows:Vial stoppers are not manufactured with natural rubber latex. Store AKOVAZ (ephedrine sulfate injection), 50 mg/mL, at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature]. Store in carton until time of use. For single use only. Discard unused portion. Manufactured for:Avadel Legacy Pharmaceuticals, LLCChesterfield, MO 63005For BluePoint LaboratoriesRev. 06/2017


×

Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Ephedrine sulfate is a sympathomimetic amine that directly acts as an agonist at α- and β-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. Pressor effects by direct alpha- and beta-adrenergic receptor activation are mediated by increases in arterial pressures, cardiac output, and peripheral resistance. Indirect adrenergic stimulation is caused by norepinephrine release from sympathetic nerves.

Non-Clinical Toxicology
None

Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.

Serious postpartum hypertension has been described in patients who received both a vasopressor (i.e., methoxamine, phenylephrine, ephedrine) and an oxytocic (i.e., methylergonovine, ergonovine) []. Some of these patients experienced a stroke. Carefully monitor the blood pressure of individuals who have received both ephedrine and an oxytocic.

The following adverse reactions associated with the use of ephedrine sulfate were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or to establish a causal relationship to drug exposure.

Gastrointestinal disorders:

Cardiac disorders:

Nervous system disorders:

Psychiatric disorders:

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

Rate this treatment and share your opinion


Learn about User Reviews

Helpful tips to write a good review:

  1. Only share your first hand experience as a consumer or a care giver.
  2. Describe your experience in the Comments area including the benefits, side effects and how it has worked for you. Do not provide personal information like email addresses or telephone numbers.
  3. Fill in the optional information to help other users benefit from your review.

Reason for Taking This Treatment

(required)

Click the stars to rate this treatment

Effectiveness (required)

This medication has worked for me.




Ease of Use (required)

This medication has been easy for me to use.




Satisfaction (required)

Overall, I have been satisfied with my experience.




Write a brief description of your experience with this treatment:

2000 characters remaining

Optional Information

Help others benefit from your review by filling in the information below.
I am a:
Gender:
×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
×

Tips

Tips

×

Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).