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Akten

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Overview

What is Akten?

Akten (lidocaine hydrochloride ophthalmic gel) 3.5% is a sterile, preservative-free, single patient use ophthalmic gel preparation for topical ocular anesthesia. Lidocaine hydrochloride is designated chemically as acetamide, 2-(diethylamino)-N-(2,6- dimethylphenyl) monohydrochloride with a molecular formula of CHNO HCl and molecular weight of 270.8. The structural formula of the active ingredient is:

Akten contains 35 mg of lidocaine hydrochloride per mL as the active ingredient. Akten also contains Hypromellose, Sodium Chloride, and Water for Injection as inactive ingredients in the 1 mL tube configuration. Akten contains Hypromellose, Sodium Chloride, and Purified Water as inactive ingredients in the 5 mL in 10 mL bottle configuration. The pH may be adjusted to 5.5 to 7.5 with Hydrochloric Acid and/or Sodium Hydroxide.



What does Akten look like?



What are the available doses of Akten?

Akten 3.5% (35 mg/mL) Ophthalmic Gel ()

What should I talk to my health care provider before I take Akten?

How should I use Akten?

Akten is indicated for ocular surface anesthesia during ophthalmologic procedures.

The recommended dose of Akten is 2 drops applied to the ocular surface in the area of the planned procedure. Akten may be reapplied to maintain anesthetic effect.


What interacts with Akten?

Sorry No Records found


What are the warnings of Akten?

Sorry No Records found


What are the precautions of Akten?

Sorry No Records found


What are the side effects of Akten?

Sorry No records found


What should I look out for while using Akten?

None


What might happen if I take too much Akten?

Prolonged use of a topical ocular anesthetic may produce permanent corneal opacification and ulceration with accompanying visual loss.

Acute emergencies from local anesthetics are generally related to high plasma levels encountered during therapeutic use of local anesthetics or to unintended subarachnoid injection of local anesthetic solution.

However, topical ocular application of Akten is not expected to result in systemic exposure.


How should I store and handle Akten?

Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Care should be exercised in the handling of REVLIMID. REVLIMID capsules should not be opened or broken. If powder from REVLIMID contacts the skin, wash the skin immediately and thoroughly with soap and water. If REVLIMID contacts the mucous membranes, flush thoroughly with water.Procedures for the proper handling and disposal of anticancer drugs should be considered. Several guidelines on the subject have been published. Dispense no more than a 28-day supply.Akten (lidocaine hydrochloride ophthalmic gel) 3.5% is supplied as a clear gel for single patient use as follows: NDC 17478-792-01                    1 mL fill in a white polyfoil tube*NDC 17478-792-25                    Package of 25 units of 1 mL fill in a white polyfoil tube*                                                         (NDC 17478-792-01)NDC 17478-792-10                    5 mL fill in a 10 mL natural, round plastic dropper bottle Akten (lidocaine hydrochloride ophthalmic gel) 3.5% is supplied as a clear gel for single patient use as follows: NDC 17478-792-01                    1 mL fill in a white polyfoil tube*NDC 17478-792-25                    Package of 25 units of 1 mL fill in a white polyfoil tube*                                                         (NDC 17478-792-01)NDC 17478-792-10                    5 mL fill in a 10 mL natural, round plastic dropper bottle


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Akten is a local anesthetic agent that stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses, thereby effecting local anesthetic action. Anesthesia generally occurs between 20 seconds to 1 minute and persists for 5 to 30 minutes.

Non-Clinical Toxicology
None

Disulfiram appears to decrease the rate at which certain drugs are metabolized and therefore may increase the blood levels and the possibility of clinical toxicity of drugs given concomitantly.

DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS RECEIVING PHENYTOIN AND ITS CONGENERS, SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION. PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. SUBSEQUENT TO INITIATION OF DISULFIRAM THERAPY, SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINED ON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.

It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram, since disulfiram may prolong prothrombin time.

Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status, the disulfiram should be discontinued if such signs appear.

In rats, simultaneous ingestion of disulfiram and nitrite in the diet for 78 weeks has been reported to cause tumors, and it has been suggested that disulfiram may react with nitrites in the rat stomach to form a nitrosamine, which is tumorigenic. Disulfiram alone in the rat's diet did not lead to such tumors. The relevance of this finding to humans is not known at this time.

Not for Injection ()

Corneal Opacification- prolonged use of a topical ocular anesthetic may produce permanent corneal opacification and ulceration with accompanying visual loss ()

Most common adverse reactions are conjunctival hyperemia, corneal epithelial changes, headache, and burning upon instillation.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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