Alfentanil Hydrochloride

×

Overview

What is Alfentanil Hydrochloride?

Alfentanil HCl Injection, contains alfentanil, an opioid agonist, chemically designated as N- [1- [2-(4-ethyl-4,5-dihydro-5-oxo-1H-

tetrazol-1- yl) ethyl]-4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide monohydrochloride (1:1) with a molecular weight of 452.98 and an n-octanol: water partition coefficient of 128:1 at pH 7.4. The structural formula of Alfentanil HCl is:

Alfentanil HCl Injection, USP is a sterile, non-pyrogenic, preservative free aqueous solution containing alfentanil hydrochloride equivalent to 500 mcg per mL of alfentanil base for intravenous injection. The solution, which contains sodium chloride for isotonicity, has a pH range of 4.0 to 6.0. Each mL contains:

Active:

Inactive:

What does Alfentanil Hydrochloride look like?

What are the available doses of Alfentanil Hydrochloride?

Solution for injection (sterile): eq. to 500 mcg/mL alfentanil base; 2 mL, 5 mL, 10 mL and 20 mL ampules. ()

What should I talk to my health care provider before I take Alfentanil Hydrochloride?

How should I use Alfentanil Hydrochloride?

Alfentanil HCl Injection is indicated:

Alfentanil HCl Injection should be administered only by persons specifically trained in the use of intravenous anesthetics and management of the respiratory effects of potent opioids.

In patients administered high doses of Alfentanil HCl Injection, it is essential that qualified personnel and adequate facilities are available for the management of postoperative respiratory depression.

As with other potent opioids, the respiratory depressant effect of alfentanil may persist longer than the measured analgesic effect. The total dose of all opioid agonists administered should be considered by the practitioner before ordering opioid analgesics during recovery from anesthesia.

If Alfentanil HCl Injection is administered with a CNS depressant, become familiar with the properties of each drug, particularly each product's duration of action. In addition, when such a combination is used, fluids and other countermeasures to manage hypotension should be available

The physical and chemical compatibility of Alfentanil HCl Injection have been demonstrated in solution with normal saline, 5% dextrose in normal saline, 5% dextrose in water and Lactated Ringers. Clinical studies of Alfentanil HCl Injection infusion have been conducted with Alfentanil HCl Injection diluted to a concentration range of 25 mcg/mL to 80 mcg/mL.

As an example of the preparation of Alfentanil HCl Injection for infusion, 20 mL of Alfentanil HCl injection added to 230 mL of diluent provides 40 mcg/mL solution of Alfentanil.

What interacts with Alfentanil Hydrochloride?

Sorry No Records found

What are the warnings of Alfentanil Hydrochloride?

Sorry No Records found

What are the precautions of Alfentanil Hydrochloride?

Sorry No Records found

What are the side effects of Alfentanil Hydrochloride?

Sorry No records found

What should I look out for while using Alfentanil Hydrochloride?

Alfentanil HCl Injection is contraindicated in patients with:

Addiction, Abuse, and Misuse

Alfentanil HCl injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing Alfentanil HCl Injection, and monitor all patients regularly for the development of these behaviors and conditions

[see Warnings and Precautions ()].

What might happen if I take too much Alfentanil Hydrochloride?

How should I store and handle Alfentanil Hydrochloride?

Store at 20° to 25°C (68° to 77°F); see USP controlled room temperature. Protect from light. Do not freeze.Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16 Alfentanil HCl Injection, USP for intravenous use is a sterile, aqueous, preservative free solution. Each mL contains: Active: Alfentanil base 500 mcg. Inactives: Sodium Chloride 9 mg and WFI q.s. Alfentanil HCl Injection, USP available as: NDC 17478-067-02, 2 mL Ampule in packages of 10 NDC 17478-067-05, 5 mL Ampule in packages of 10 NDC 17478-067-10, 10 mL Ampule in packages of 5 NDC 17478-067-20, 20 mL Ampule in packages of 5 Alfentanil HCl Injection, USP is supplied in individually sealed dosage forms which pose no known risk to health care providers having incidental contact. Accidental dermal exposure to alfentanil should be treated by rinsing the affected area with water. Store at 20° to 25°C (68 to 77°F). [See USP Controlled Room Temperature]. Protect from light. AKORN Manufactured by: Lake Forest, IL 60045AFA0N Rev. 12/16

×

Clinical Information

Chemical Structure

No Image found

Clinical Pharmacology

Alfentanil HCl Injection is an opioid agonist. The principal actions of therapeutic value are analgesia and sedation.

Non-Clinical Toxicology

Alfentanil HCl Injection is contraindicated in patients with:

Addiction, Abuse, and Misuse

Alfentanil HCl injection exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Assess each patient's risk prior to prescribing Alfentanil HCl Injection, and monitor all patients regularly for the development of these behaviors and conditions

[see Warnings and Precautions ()].

Oral metronidazole has been reported to potentiate the anticoagulant effect of warfarin and coumarin anticoagulants, resulting in a prolongation of prothrombin time. The effect of topical metronidazole on prothrombin time is not known.

Alfentanil HCl Injection contains alfentanil, a Schedule II controlled substance. As an opioid, Alfentanil HCl Injection exposes users to the risks of addiction, abuse, and misuse

Opioids are sought by drug abusers and people with addiction disorders and are subject to criminal diversion. Consider these risks when handling Alfentanil HCl Injection. Strategies to reduce these risks include proper product storage and control practices for a C-II drug.

Contact local and state professional licensing board or state controlled substances authority for information on how to prevent and detect abuse or diversion of this product.

The following serious adverse reactions are described, or described in greater detail, in other sections:

×

Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

×

Review

×

Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72

×

Tips

×

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).

Disclaimer: