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Amlodipine, Valsartan and Hydrochlorothiazide
Overview
What is Amlodipine, Valsartan and Hydrochlorothiazide?
What does Amlodipine, Valsartan and Hydrochlorothiazide look like?
What are the available doses of Amlodipine, Valsartan and Hydrochlorothiazide?
Tablets: (amlodipine/valsartan/hydrochlorothiazide mg) 5/160/12.5, 5/160/25, 10/160/12.5, 10/160/25, 10/320/25 (3)
What should I talk to my health care provider before I take Amlodipine, Valsartan and Hydrochlorothiazide?
Nursing Mothers:
Geriatric Patients:
Hepatic Impairment:
How should I use Amlodipine, Valsartan and Hydrochlorothiazide?
Dose once-daily. The dosage may be increased after 2 weeks of therapy. The full blood pressure lowering effect was achieved 2 weeks after being on the maximal dose of amlodipine, valsartan and hydrochlorothiazide tablets. The maximum recommended dose of amlodipine, valsartan and hydrochlorothiazide tablets is 10 mg/320 mg/25 mg.
What interacts with Amlodipine, Valsartan and Hydrochlorothiazide?
Sorry No Records found
What are the warnings of Amlodipine, Valsartan and Hydrochlorothiazide?
Sorry No Records found
What are the precautions of Amlodipine, Valsartan and Hydrochlorothiazide?
Sorry No Records found
What are the side effects of Amlodipine, Valsartan and Hydrochlorothiazide?
Sorry No records found
What should I look out for while using Amlodipine, Valsartan and Hydrochlorothiazide?
Anuria (4)
Hypersensitivity to sulfonamide-derived drugs (4)
Known hypersensitivity to any component (4)
Do not coadminister aliskiren with amlodipine, valsartan and hydrochlorothiazide in patients with diabetes (4)
What might happen if I take too much Amlodipine, Valsartan and Hydrochlorothiazide?
How should I store and handle Amlodipine, Valsartan and Hydrochlorothiazide?
ArrayAmlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP. Amlodipine, valsartan and hydrochlorothiazide tablets, USP are available as film-coated tablets containing amlodipine besylate equivalent to 5 mg or 10 mg of amlodipine free-base with valsartan 160 mg or 320 mg, and hydrochlorothiazide 12.5 mg or 25 mg, providing for the following available combinations: 5 mg/160 mg/12.5 mg, 5 mg/160 mg/25 mg, 10 mg/160 mg/12.5 mg, 10 mg/160 mg/25 mg, and 10 mg/320 mg/25 mg. All strengths are packaged in bottles of 30, 100, 500 tablets and 100 (10X10) unit dose blister package.5 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-326-30Bottles of 100 NDC 13668-326-01Bottles of 500 NDC 13668-326-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-326-745 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-329-30Bottles of 100 NDC 13668-329-01Bottles of 500 NDC 13668-329-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-329-7410 mg amlodipine/160 mg valsartan/12.5 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-327-30Bottles of 100 NDC 13668-327-01Bottles of 500 NDC 13668-327-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-327-74 10 mg amlodipine/160 mg valsartan/25 mg hydrochlorothiazide TabletsBottles of 30 NDC 13668-328-30Bottles of 100 NDC 13668-328-01Bottles of 500 NDC 13668-328-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-328-7410 mg amlodipine/320 mg valsartan/25 mg hydrochlorothiazide Tablets Bottles of 30 NDC 13668-325-30Bottles of 100 NDC 13668-325-01Bottles of 500 NDC 13668-325-05Carton of 100 tablets (10 x 10 unit-dose) NDC 13668-325-74Store at 20° to 25°C (68° to 77°F); excursions permitted between 15°C and 30°C (59°F and 86°F) [see USP Controlled Room Temperature].Protect from moisture. Dispense in a tight container as defined in the USP.
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
The active ingredients of amlodipine, valsartan and hydrochlorothiazide tablets target 3 separate mechanisms involved in blood pressure regulation. Specifically, amlodipine blocks the contractile effects of calcium on cardiac and vascular smooth muscle cells; valsartan blocks the vasoconstriction and sodium retaining effects of angiotensin II on cardiac, vascular smooth muscle, adrenal and renal cells; and hydrochlorothiazide directly promotes the excretion of sodium and chloride in the kidney leading to reductions in intravascular volume. A more detailed description of the mechanism of action of each individual component follows.
Amlodipine
Amlodipine is a dihydropyridine calcium channel blocker that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle. Experimental data suggest that amlodipine binds to both dihydropyridine and nondihydropyridine binding sites. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. Amlodipine inhibits calcium ion influx across cell membranes selectively, with a greater effect on vascular smooth muscle cells than on cardiac muscle cells. Negative inotropic effects can be detected but such effects have not been seen in intact animals at therapeutic doses. Serum calcium concentration is not affected by amlodipine. Within the physiologic pH range, amlodipine is an ionized compound (pKa=8.6), and its kinetic interaction with the calcium channel receptor is characterized by a gradual rate of association and dissociation with the receptor binding site, resulting in a gradual onset of effect.
Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.
Valsartan
Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis.
There is also an AT receptor found in many tissues, but AT is not known to be associated with cardiovascular homeostasis. Valsartan has much greater affinity (about 20000-fold) for the AT receptor than for the AT receptor. The increased plasma levels of angiotensin following AT receptor blockade with valsartan may stimulate the unblocked AT receptor. The primary metabolite of valsartan is essentially inactive with an affinity for the AT receptor about one-200 that of valsartan itself.
Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension. ACE inhibitors also inhibit the degradation of bradykinin, a reaction also catalyzed by ACE. Because valsartan does not inhibit ACE (kininase II), it does not affect the response to bradykinin. Whether this difference has clinical relevance is not yet known. Valsartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure.
Hydrochlorothiazide
Hydrochlorothiazide is a thiazide diuretic. Thiazides affect the renal tubular mechanisms of electrolyte reabsorption, directly increasing excretion of sodium and chloride in approximately equivalent amounts. Indirectly, the diuretic action of hydrochlorothiazide reduces plasma volume, with consequent increases in plasma renin activity, increases in aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium. The renin-aldosterone link is mediated by angiotensin II, so coadministration of an angiotensin II receptor antagonist tends to reverse the potassium loss associated with these diuretics.
The mechanism of the antihypertensive effect of thiazides is unknown.
Non-Clinical Toxicology
Anuria (4)Hypersensitivity to sulfonamide-derived drugs (4)
Known hypersensitivity to any component (4)
Do not coadminister aliskiren with amlodipine, valsartan and hydrochlorothiazide in patients with diabetes (4)
Nephrotoxicity has been reported following concomitant administration of cephalosporins with aminoglycoside antibacterial drugs or potent diuretics such as furosemide. Renal function should be carefully monitored, especially if higher dosages of the aminoglycosides are to be administered or if therapy is prolonged, because of the potential nephrotoxicity and ototoxicity of aminoglycoside antibacterial drugs. Nephrotoxicity and ototoxicity were not noted when ceftazidime was given alone in clinical trials.
Chloramphenicol has been shown to be antagonistic to beta-lactam antibacterial drugs, including ceftazidime, based on in vitro studies and time kill curves with enteric gram-negative bacilli. Due to the possibility of antagonism in vivo, particularly when bactericidal activity is desired, this drug combination should be avoided.
In common with other antibacterial drugs, ceftazidime may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.
Pregnancy Category D
Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue amlodipine, valsartan and hydrochlorothiazide tablets as soon as possible see Use in Specific Populatio.
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
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Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72Tips
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Interactions
A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).