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HYDROCORTISONE ACETATE

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Overview

What is Anusol HC?

Each Anusol-HC 25-mg Suppository contains 25 mg hydrocortisone acetate in a hydrogenated vegetable oil base. Hydrocortisone acetate is a corticosteroid. Chemically, hydrocortisone acetate is pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy (11ß)- with the following structural formula:



What does Anusol HC look like?



What are the available doses of Anusol HC?

Sorry No records found.

What should I talk to my health care provider before I take Anusol HC?

Sorry No records found

How should I use Anusol HC?

For use in inflamed hemorrhoids, post-irradiation (factitial) proctitis, as an adjunct in the treatment of chronic ulcerative colitis, cryptitis, other inflammatory conditions of the anorectum, and pruritus ani.

Usual dosage:


What interacts with Anusol HC?

Sorry No Records found


What are the warnings of Anusol HC?

Sorry No Records found


What are the precautions of Anusol HC?

Do not use unless adequate proctologic examination is made.

If irritation develops, the product should be discontinued and appropriate therapy instituted.

In the presence of an infection, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

No long-term studies in animals have been performed to evaluate the carcinogenic potential of corticosteroid suppositories.


What are the side effects of Anusol HC?

The following local adverse reactions have been reported with corticosteroid suppositories.

To report SUSPECTED ADVERSE REACTIONS, contact Salix Pharmaceuticals at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

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What should I look out for while using Anusol HC?

 Anusol-HC suppositories are contraindicated in those patients with a history of hypersensitivity to any of the components.


What might happen if I take too much Anusol HC?

If signs and symptoms of systemic overdosage occur, discontinue use.


How should I store and handle Anusol HC?

Inspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The product may be filtered using a sterile filter if particles are seen subsequent to opening of the ampoule.OPC ampoule: to open, turn so that the point faces upward and break off the neck with a downward movement.ArrayInspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The product may be filtered using a sterile filter if particles are seen subsequent to opening of the ampoule.OPC ampoule: to open, turn so that the point faces upward and break off the neck with a downward movement.ArrayInspect parenteral drug products visually for particulate matter and discoloration prior to administration, whenever solution and container permit. The product may be filtered using a sterile filter if particles are seen subsequent to opening of the ampoule.OPC ampoule: to open, turn so that the point faces upward and break off the neck with a downward movement.ArrayAnusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1Anusol-HC 25-mg Suppositories are white, cylinder shaped, with one end tapered. Package of 12 suppositories (NDC 65649-411-12) and package of 24 suppositories (NDC 65649-411-24).Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Store away from heat. PROTECT FROM FREEZING.Manufactured forPharmaceuticals North America LLC, Bridgewater, NJ 08807 USAOPENING INSTRUCTIONSAvoid excessive handling of the suppository. 1. Separate plastic film at top opening and pull downward. 2. Continue pulling downward to almost the full length of the suppository.3. Gently remove the suppository from the film pocket. Rev. 04/2016952070022013189B500 9L J1


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

In normal subjects, about 26 percent of hydrocortisone acetate is absorbed when the hydrocortisone acetate suppository is applied to the rectum. Absorption of hydrocortisone acetate may vary across abraded or inflamed surfaces.

Topical steroids are primarily effective because of their anti-inflammatory, anti-pruritic and vasoconstrictive action.

Non-Clinical Toxicology
 Anusol-HC suppositories are contraindicated in those patients with a history of hypersensitivity to any of the components.









Table 2 summarizes the results and magnitude of the pertinent drug interactions assessed with rifabutin. The clinical relevance of these interactions and subsequent dose modifications should be judged in light of the population studied, severity of the disease, patient's drug profile, and the likely impact on the risk/benefit ratio.





Do not use unless adequate proctologic examination is made.

If irritation develops, the product should be discontinued and appropriate therapy instituted.

In the presence of an infection, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

No long-term studies in animals have been performed to evaluate the carcinogenic potential of corticosteroid suppositories.

The following local adverse reactions have been reported with corticosteroid suppositories.

To report SUSPECTED ADVERSE REACTIONS, contact Salix Pharmaceuticals at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).