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Apraclonidine

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Overview

What is Apraclonidine?

Apraclonidine Ophthalmic Solution contains apraclonidine hydrochloride, an alpha adrenergic agonist, in a sterile isotonic solution for topical application to the eye. Apraclonidine hydrochloride is a white to off-white powder and is highly soluble in water. Its chemical name is 2-[(4-amino-2,6 dichlorophenyl) imino]imidazolidine monohydrochloride with an empirical formula of CHClN and a molecular weight of 281.57. The chemical structure of apraclonidine hydrochloride is:

Each mL of Apraclonidine Ophthalmic Solution contains: Active:

Preservative:

Inactives:



What does Apraclonidine look like?



What are the available doses of Apraclonidine?

Sorry No records found.

What should I talk to my health care provider before I take Apraclonidine?

Sorry No records found

How should I use Apraclonidine?

Apraclonidine Ophthalmic Solution, 0.5% as base is indicated for short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional IOP reduction. Patients on maximally tolerated medical therapy who are treated with Apraclonidine Ophthalmic Solution to delay surgery should have frequent followup examinations and treatment should be discontinued if the intraocular pressure rises significantly.

The addition of Apraclonidine Ophthalmic Solution to patients already using two aqueous suppressing drugs (i.e., beta-blocker plus carbonic anhydrase inhibitor) as part of their maximally tolerated medical therapy may not provide additional benefit. This is because Apraclonidine Ophthalmic Solution is an aqueous suppressing drug and the addition of a third aqueous suppressant may not significantly reduce IOP.

The IOP lowering efficacy of Apraclonidine Ophthalmic Solution diminishes over time in some patients. This loss of effect, or tachyphylaxis, appears to be an individual occurrence with a variable time of onset and should be closely monitored. The benefit for most patients is less than one month.

One to two drops of Apraclonidine Ophthalmic Solution, 0.5% as base should be instilled in the affected eye(s) three times daily. Since Apraclonidine Ophthalmic Solution will be used with other ocular glaucoma therapies, an approximate 5 minute interval between instillation of each medication should be practiced to prevent washout of the previous dose.

NOT FOR INJECTION INTO THE EYE. NOT FOR ORAL INGESTION.


What interacts with Apraclonidine?

Sorry No Records found


What are the warnings of Apraclonidine?

Sorry No Records found


What are the precautions of Apraclonidine?

Sorry No Records found


What are the side effects of Apraclonidine?

Sorry No records found


What should I look out for while using Apraclonidine?

Apraclonidine Ophthalmic Solution is contraindicated in patients with hypersensitivity to apraclonidine or any other component of this medication, as well as systemic clonidine. It is also contraindicated in patients receiving monoamine oxidase inhibitors (MAO inhibitors).

Not for injection or oral ingestion. FOR TOPICAL OPHTHALMIC USE ONLY.


What might happen if I take too much Apraclonidine?

Ingestion of Apraclonidine Ophthalmic Solution, 0.5% as base has been reported to cause bradycardia, drowsiness, and hypothermia.

Accidental or intentional ingestion of oral clonidine has been reported to cause apnea, arrhythmias, asthenia, bradycardia, conduction defects, diminished or absent reflexes, dryness of the mouth, hypotension, hypothermia, hypoventilation, irritability, lethargy, miosis, pallor, respiratory depression, sedation or coma, seizure, somnolence, transient hypertension, and vomiting.

Treatment of an oral overdose includes supportive and symptomatic therapy; a patent airway should be maintained. Hemodialysis is of limited value since a maximum of 5% of circulating drug is removed.


How should I store and handle Apraclonidine?

Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Storage ConditionsStore refrigerated between 2° and 8°C (36° and 46°F). Upon removal from refrigeration to room temperature storage conditions (25°C / 77°F), use Rocuronium Bromide Injection within 60 days. Use opened vials of Rocuronium Bromide Injection within 30 days. Do not freeze.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.Apraclonidine Ophthalmic Solution, 0.5% as base in a sterile, isotonic, aqueous solution containing apraclonidine hydrochloride.Supplied in plastic ophthalmic DROP-TAINER®* dispenser as follows:5 mL 61314-665-0510 mL 61314-665-10Storage: To report SUSPECTED ADVERSE REACTIONS, contact Sandoz Inc., at 1-800-525-8747 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Rx Only*DROP-TAINER® is a registered trademark of Alcon Research, Ltd.