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Anastrozole

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Overview

What is ARIMIDEX?

ARIMIDEX (anastrozole) tablets for oral administration contain 1 mg of anastrozole, a non-steroidal aromatase inhibitor. It is chemically described as 1,3-Benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl). Its molecular formula is CHN and its structural formula is:

Anastrozole is an off-white powder with a molecular weight of 293.4. Anastrozole has moderate aqueous solubility (0.5 mg/mL at 25°C); solubility is independent of pH in the physiological range. Anastrozole is freely soluble in methanol, acetone, ethanol, and tetrahydrofuran, and very soluble in acetonitrile.

Each tablet contains as inactive ingredients: lactose, magnesium stearate, hydroxypropylmethylcellulose, polyethylene glycol, povidone, sodium starch glycolate, and titanium dioxide.



What does ARIMIDEX look like?



What are the available doses of ARIMIDEX?

1 mg tablets ()

What should I talk to my health care provider before I take ARIMIDEX?

How should I use ARIMIDEX?

ARIMIDEX is indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.

The dose of ARIMIDEX is one 1 mg tablet taken once a day. For patients with advanced breast cancer, ARIMIDEX should be continued until tumor progression. ARIMIDEX can be taken with or without food.

For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, ARIMIDEX was administered for five years [see ].

No dosage adjustment is necessary for patients with renal impairment or for elderly patients [see ].


What interacts with ARIMIDEX?

Sorry No Records found


What are the warnings of ARIMIDEX?

Sorry No Records found


What are the precautions of ARIMIDEX?

Sorry No Records found


What are the side effects of ARIMIDEX?

Sorry No records found


What should I look out for while using ARIMIDEX?





4.2


What might happen if I take too much ARIMIDEX?

Clinical trials have been conducted with ARIMIDEX, up to 60 mg in a single dose given to healthy male volunteers and up to 10 mg daily given to postmenopausal women with advanced breast cancer; these dosages were tolerated. A single dose of ARIMIDEX that results in life-threatening symptoms has not been established. There is no specific antidote to overdosage and treatment must be symptomatic. In the management of an overdose, consider that multiple agents may have been taken. Vomiting may be induced if the patient is alert. Dialysis may be helpful because ARIMIDEX is not highly protein bound. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated.


How should I store and handle ARIMIDEX?

These tablets are supplied in bottles of 30 tablets (NDC 0310-0201-30).