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Atenolol
Overview
What is Atenolol?
What does Atenolol look like?
What are the available doses of Atenolol?
Sorry No records found.
What should I talk to my health care provider before I take Atenolol?
Sorry No records found
How should I use Atenolol?
What interacts with Atenolol?
Sorry No Records found
What are the warnings of Atenolol?
Cardiac Failure
In Patients Without a History of Cardiac Failure
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DOSAGE AND ADMNISTRATION
Cessation of Therapy with Atenolol
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DOSAGE AND ADMINISTRATION
Concomitant Use of Calcium Channel Blockers
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PRECAUTIONS
Bronchospastic Diseases
PATIENTS WITH BRONCHOSPASTIC DISEASE SHOULD, IN GENERAL, NOT RECEIVE BETA-BLOCKERS. Because of its relative beta selectivity, however, atenolol may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. Since betaselectivity is not absolute, the lowest possible dose of atenolol should be used with therapy initiated at 50 mg and a beta-stimulating agent (bronchodilator) should be made available. If dosage must be increased, dividing the dose should be considered in order to achieve lower peak blood levels.
Anesthesia and Major Surgery
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OVERDOSAGE
Diabetes and Hypoglycemia
Thyrotoxicosis
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DOSAGE AND ADMINISTRATION
Untreated Pheochromocytoma
Pregnancy and Fetal Injury
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PRECAUTIONS, Nursing Mothers
What are the precautions of Atenolol?
General
Impaired Renal Function
Drug Interactions
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WARNINGS
Carcinogenesis, Mutagenesis, Impairment of Fertility
in vivo
S typhimurium
Animal Toxicology
Usage in Pregnancy
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WARNINGS - Pregnancy and Fetal Injury
Nursing Mothers
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WARNINGS, Pregnancy and Fetal Injury
Pediatric Use
Geriatric Use
Hypertension and Angina Pectoris Due to Coronary Atherosclerosis
Acute Myocardial Infarction
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What are the side effects of Atenolol?
Most adverse effects have been mild and transient.
The frequency estimates in the following table were derived from controlled studies in hypertensive patients in which adverse reactions were either volunteered by the patient (US studies) or elicited, e.g., by checklist (foreign studies). The reported frequency of elicited adverse effects was higher for both atenolol and placebo-treated patients than when these reactions were volunteered. Where frequency of adverse effects of atenolol and placebo is similar, causal relationship to atenolol is uncertain.
| Volunteered( ) | Total-Volunteeredand Elicited ( ) | |||
| Atenolol(n = 164)% | Placebo(n = 206) % | Atenolol(n = 399) % | Placebo(n = 407) % | |
| CARDIOVASCULAR | ||||
| Bradycardia | 3 | 0 | 3 | 0 |
| Cold Extremities | 0 | 0.5 | 12 | 5 |
| Postural Hypotension | 2 | 1 | 4 | 5 |
| Leg Pain | 0 | 0.5 | 3 | 1 |
| CENTRAL NERVOUS SYSTEM/ NEUROMUSCULAR | ||||
| Dizziness | 4 | 1 | 13 | 6 |
| Vertigo | 2 | 0.5 | 2 | 0.2 |
| Lightheadedness | 1 | 0 | 3 | 0.7 |
| Tiredness | 0.6 | 0.5 | 26 | 13 |
| Fatigue | 3 | 1 | 6 | 5 |
| Lethargy | 1 | 0 | 3 | 0.7 |
| Drowsiness | 0.6 | 0 | 2 | 0.5 |
| Depression | 0.6 | 0.5 | 12 | 9 |
| Dreaming | 0 | 0 | 3 | 1 |
| GASTROINTESTINAL | ||||
| Diarrhea | 2 | 0 | 3 | 2 |
| Nausea | 4 | 1 | 3 | 1 |
| RESPIRATORY (see WARNINGS) | ||||
| Wheeziness | 0 | 0 | 3 | 3 |
| Dyspnea | 0.6 | 1 | 6 | 4 |
Acute Myocardial Infarction
In a series of investigations in the treatment of acute myocardial infarction, bradycardia and hypotension occurred more commonly, as expected for any beta-blocker, in atenolol-treated patients than in control patients. However, these usually responded to atropine and/or to withholding further dosages of atenolol. The incidence of heart failure was not increased by atenolol. Inotropic agents were infrequently used. The reported frequency of these and other events occurring during these investigations is given in the following table.
In a study of 477 patients, the following adverse events were reported during either intravenous and/or oral atenolol administration:
In the subsequent International Study of Infarct Survival (ISIS-1) including over 16,000 patients of whom 8,037 were randomized to receive atenolol treatment, the dosage of intravenous and subsequent oral atenolol was either discontinued or reduced for the following reasons:
During postmarketing experience with atenolol, the following have been reported in temporal relationship to the use of the drug: elevated liver enzymes and/or bilirubin, hallucinations, headache, impotence, Peyronie's disease, postural hypotension which may be associated with syncope, psoriasiform rash or exacerbation of psoriasis, psychoses, purpura, reversible alopecia, thrombocytopenia, visual disturbances, sick sinus syndrome, and dry mouth. Atenolol, like other beta-blockers, has been associated with the development of antinuclear antibodies (ANA), lupus syndrome, and Raynaud’s phenomenon.
| Conventional TherapyPlus Atenolol(n=244) | ConventionalTherapy Alone(n=233) | |||
| Bradycardia | 43 | (18%) | 24 | (10%) |
| Hypotension | 60 | (25%) | 34 | (15%) |
| Bronchospasm | 3 | (1.2%) | 2 | (0.9%) |
| Heart Failure | 46 | (19%) | 56 | (24%) |
| Heart Block | 11 | (4.5%) | 10 | (4.3%) |
| BBB + MajorAxis Deviation | 16 | (6.6%) | 28 | (12%) |
| Supraventricular Tachycardia | 28 | (11.5%) | 45 | (19%) |
| Atrial Fibrillation | 12 | (5%) | 29 | (11%) |
| Atrial Flutter | 4 | (1.6%) | 7 | (3%) |
| Ventricular Tachycardia | 39 | (16%) | 52 | (22%) |
| Cardiac Reinfarction | 0 | (0%) | 6 | (2.6%) |
| Total Cardiac Arrests | 4 | (1.6%) | 16 | (6.9%) |
| Nonfatal Cardiac Arrests | 4 | (1.6%) | 12 | (5.1%) |
| Deaths | 7 | (2.9%) | 16 | (6.9%) |
| Cardiogenic Shock | 1 | (0.4%) | 4 | (1.7%) |
| Development of VentricularSeptal Defect | 0 | (0%) | 2 | (0.9%) |
| Development of MitralRegurgitation | 0 | (0%) | 2 | (0.9%) |
| Renal Failure | 1 | (0.4%) | 0 | (0%) |
| Pulmonary Emboli | 3 | (1.2%) | 0 | (0%) | Full dosage was 10 mg and some patients received less than 10 mg but more than 5 mg. | Oral PartialDose |
| Hypotension / Bradycardia | 105 | (1.3%) | 1168 | (14.5%) |
| Cardiogenic Shock | 4 | (.04%) | 35 | (.44%) |
| Reinfarction | 0 | (0%) | 5 | (.06%) |
| Cardiac Arrest | 5 | (.06%) | 28 | (.34%) |
| Heart Block (> first degree) | 5 | (.06%) | 143 | (1.7%) |
| Cardiac Failure | 1 | (.01%) | 233 | (2.9%) |
| Arrhythmias | 3 | (.04%) | 22 | (.27%) |
| Bronchospasm | 1 | (.01%) | 50 | (.62%) |
What should I look out for while using Atenolol?
What might happen if I take too much Atenolol?
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How should I store and handle Atenolol?
Store at 25°C (77°F); excursions permitted to 15°C-30°C (59°F-86°F) [see USP Controlled Room Temperature].They are supplied by as follows:This Product was Repackaged By:State of Florida DOH Central PharmacyThey are supplied by as follows:This Product was Repackaged By:State of Florida DOH Central PharmacyThey are supplied by as follows:This Product was Repackaged By:State of Florida DOH Central Pharmacy
Clinical Information
Chemical Structure
No Image foundClinical Pharmacology
Non-Clinical Toxicology
Reference
This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"
While we update our database periodically, we cannot guarantee it is always updated to the latest version.
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Interactions
Interactions
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