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Auryxia

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Overview

What is Auryxia?

Auryxia (ferric citrate), a phosphate binder and iron replacement product, is known chemically as iron (+3), (1, 2, 3-propanetricarboxylic acid, 2 hydroxy-), (HO)

Auryxia 210 mg ferric iron tablets for oral administration, equivalent to 1g ferric citrate, are film-coated, peach-colored, and oval-shaped tablets debossed with “KX52”. The inactive ingredients are pregelatinized starch and calcium stearate. In addition, the film-coating contains the following inactive ingredients; hypromellose, titanium dioxide, triacetin, and FD&C Yellow #6/Sunset Yellow FCF Aluminum Lake, FD&C Red #40/Allura Red AC Aluminum Lake, and FD&C Blue #2/Indigo Carmine Aluminum Lake.



What does Auryxia look like?



What are the available doses of Auryxia?

Tablets: Auryxia 210 mg ferric iron, equivalent to 1 g ferric citrate, film-coated, peach-colored, and oval-shaped tablet debossed with “KX52”.

What should I talk to my health care provider before I take Auryxia?

How should I use Auryxia?

Auryxia is indicated for the control of serum phosphorus levels in adult patients with chronic kidney disease on dialysis.

The recommended starting dose is 2 tablets orally 3 times per day with meals. Monitor serum phosphorus levels and titrate the Auryxia dose in decrements or increments of 1 to 2 tablets per day as needed to maintain serum phosphorus at target levels, up to a maximum dose of 12 tablets daily. Dose can be titrated at 1-week or longer intervals.

In a clinical trial, patients required an average of 8 to 9 tablets a day to control serum phosphorus levels.


What interacts with Auryxia?

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What are the warnings of Auryxia?

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What are the precautions of Auryxia?

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What are the side effects of Auryxia?

Sorry No records found


What should I look out for while using Auryxia?

Auryxia is contraindicated in patients with iron overload syndromes (e.g., hemochromatosis) .


What might happen if I take too much Auryxia?

No data are available regarding overdose of Auryxia in patients. In patients with chronic kidney disease, the maximum dose studied was 2,520 mg ferric iron (12 tablets of Auryxia) per day. Iron absorption from Auryxia may lead to excessive elevations in iron stores, especially when concomitant intravenous iron is used .

In clinical trials, one case of elevated iron in the liver as confirmed by biopsy was reported in a patient on dialysis administered intravenous iron and Auryxia.


How should I store and handle Auryxia?

Storage: Store at 20 to 25°C (68 to 77°F): excursions permitted to 15° to 30°C (59°F to 86°F) [See USP controlled room temperature]. Protect from moisture.Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].Zolpidem tartrate 5 mg tablets, USP are red colored, capsule shaped tablets with the Torrent logo debossed on one side and '5 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9126-2Bottle of 60 - 68788-9126-6Bottle of 30 - 68788-9126-3Bottle of 90 - 68788-9126-9Zolpidem tartrate 10 mg tablets, USP are peach-yellow colored, capsule shaped tablets with the Torrent logo debossed on one side and '10 MG' debossed on the other side and supplied as:Bottle of 28 - 68788-9127-2Bottle of 60 - 68788-9127-6Bottle of 30 - 68788-9127-3Bottle of 90 - 68788-9127-9Store at 20º to 25°C (68º to 77°F); excursions permitted to 15° to 30°C (59º to 86°F) [see USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

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Clinical Pharmacology

Hyperphosphatemia in Chronic Kidney Disease on Dialysis

Ferric iron binds dietary phosphate in the GI tract and precipitates as ferric phosphate. This compound is insoluble and is excreted in the stool. By binding phosphate in the GI tract and decreasing absorption, ferric citrate lowers the phosphate concentration in the serum.

Iron Deficiency Anemia in Chronic Kidney Disease Not On Dialysis

Ferric iron is reduced from the ferric to the ferrous form by ferric reductase in the GI tract. After transport through the enterocytes into the blood, oxidized ferric iron circulates bound to the plasma protein transferrin, and can be incorporated into hemoglobin.

Non-Clinical Toxicology
Auryxia is contraindicated in patients with iron overload syndromes (e.g., hemochromatosis) .

In one survey, 2.3% of patients taking labetalol HCl in combination with tricyclic antidepressants experienced tremor, as compared to 0.7% reported to occur with labetalol HCl alone. The contribution of each of the treatments to this adverse reaction is unknown, but the possibility of a drug interaction cannot be excluded.

Drugs possessing beta-blocking properties can blunt the bronchodilator effect of beta-receptor agonist drugs in patients with bronchospasm; therefore, doses greater than the normal antiasthmatic dose of beta-agonist bronchodilator drugs may be required.

Cimetidine has been shown to increase the bioavailability of labetalol HCl. Since this could be explained either by enhanced absorption or by an alteration of hepatic metabolism of labetalol HCl, special care should be used in establishing the dose required for blood pressure control in such patients.

Synergism has been shown between halothane anesthesia and intravenously administered labetalol HCl. During controlled hypotensive anesthesia using labetalol HCl in association with halothane, high concentrations (3% or above) of halothane should not be used because the degree of hypotension will be increased and because of the possibility of a large reduction in cardiac output and an increase in central venous pressure. The anesthesiologist should be informed when a patient is receiving labetalol HCl.

Labetalol HCl blunts the reflex tachycardia produced by nitroglycerin without preventing its hypotensive effect. If labetalol HCl is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.

Care should be taken if labetalol is used concomitantly with calcium antagonists of the verapamil type.

Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.

Iron absorption from Auryxia may lead to excessive elevations in iron stores. Increases in serum ferritin and transferrin saturation (TSAT) levels were observed in clinical trials. In a 56-week safety and efficacy trial evaluating the control of serum phosphate levels in patients with chronic kidney disease on dialysis in which concomitant use of intravenous iron was permitted, 55 (19%) of patients treated with Auryxia had a ferritin level >1500 ng/mL as compared with 13 (9%) of patients treated with active control.

Assess iron parameters (e.g., serum ferritin and TSAT) prior to initiating Auryxia and monitor iron parameters while on therapy . Patients receiving intravenous iron may require a reduction in dose or discontinuation of intravenous iron therapy.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).