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Cyanocobalamin, Isopropyl Alcohol

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Overview

What is B-12 Compliance?

Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous injection. Each mL contains 1000 mcg cyanocobalamin.

Each vial also contains Sodium Chloride, 0.9%. Benzyl Alcohol, 1.5%, is present as a preservative. Hydrochloric acid and/or sodium hydroxide may have been added during manufacture to adjust the pH (range 4.5-7.0).

Cyanocobalamin appears as dark red crystals or as an amorphous or crystalline red powder. It is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80). It is stable to autoclaving for short periods at 121°C. The vitamin B coenzymes are very unstable in light.

The chemical name is 5,6-dimethyl-benzimidazolyl cyanocobamide; the molecular formula is CHCoNOP. The cobalt content is 4.34%. The molecular weight is 1355.39.

The structural formula is represented below.



What does B-12 Compliance look like?



What are the available doses of B-12 Compliance?

Sorry No records found.

What should I talk to my health care provider before I take B-12 Compliance?

Sorry No records found

How should I use B-12 Compliance?

Use as part of your daily cleansing routine

May be covered with a sterile bandage


What interacts with B-12 Compliance?

Sorry No Records found


What are the warnings of B-12 Compliance?

Sorry No Records found


What are the precautions of B-12 Compliance?

Sorry No Records found


What are the side effects of B-12 Compliance?

Sorry No records found


What should I look out for while using B-12 Compliance?

Sensitivity to cobalt and/or Vitamin B is a contraindication.

 Flammable, keep away from fire or flame.


What might happen if I take too much B-12 Compliance?

No overdosage has been reported with this drug.


How should I store and handle B-12 Compliance?

TOBI should be stored under refrigeration at 2ºC–8ºC/36ºF–46ºF. Upon removal from the refrigerator, or if refrigeration is unavailable, TOBI pouches (opened or unopened) may be stored at room temperature (up to 25ºC/77ºF) for up to 28 days. TOBI should not be used beyond the expiration date stamped on the ampule when stored under refrigeration (2ºC–8ºC/36ºF–46ºF) or beyond 28 days when stored at room temperature (25ºC/77ºF).TOBI ampules should not be exposed to intense light. The solution in the ampule is slightly yellow, but may darken with age if not stored in the refrigerator; however, the color change does not indicate any change in the quality of the product as long as it is stored within the recommended storage conditions.TOBI should be stored under refrigeration at 2ºC–8ºC/36ºF–46ºF. Upon removal from the refrigerator, or if refrigeration is unavailable, TOBI pouches (opened or unopened) may be stored at room temperature (up to 25ºC/77ºF) for up to 28 days. TOBI should not be used beyond the expiration date stamped on the ampule when stored under refrigeration (2ºC–8ºC/36ºF–46ºF) or beyond 28 days when stored at room temperature (25ºC/77ºF).TOBI ampules should not be exposed to intense light. The solution in the ampule is slightly yellow, but may darken with age if not stored in the refrigerator; however, the color change does not indicate any change in the quality of the product as long as it is stored within the recommended storage conditions.Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967 Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967 Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967 Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967 Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967 Cyanocobalamin Injection, USP 1000 mcg/mLNDC 0517-0031-25                    1 mL Fill in a 2 mL Vial                  Boxes of 25 NDC 0517-0032-25                    10 mL Multiple Dose Vial               Boxes of 25 NDC 0517-0130-05                    30 mL Multiple Dose Vial               Boxes of 5Store at 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F) (See USP Controlled Room Temperature).PROTECT THE PRODUCT FROM LIGHT.IN0031Rev. 4/14MG #10565AMERICANREGENT, INC.SHIRLEY, NY 11967


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

Vitamin B is essential to growth, cell reproduction, hematopoiesis, and nucleoprotein and myelin synthesis.

Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; the plasma level of the compound reaches its peak within 1 hour after intramuscular injection. Absorbed Vitamin B is transported via specific Bbinding proteins, transcobalamin I and II to the various tissues. The liver is the main organ for Vitamin B storage.

Within 48 hours after injection of 100 or 1000 mcg of Vitamin B, 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first eight hours. Intravenous administration results in even more rapid excretion with little opportunity for liver storage.

Gastrointestinal absorption of Vitamin B depends on the presence of sufficient intrinsic factor and calcium ions. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. Prompt parenteral administration of Vitamin B prevents progression of neurologic damage.

The average diet supplies about 5 to 15 mcg/day of Vitamin B in a protein-bound form that is available for absorption after normal digestion. Vitamin B is not present in foods of plant origin, but is abundant in foods of animal origin. In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs).

Vitamin B is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium, and Vitamin B enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins. A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses. Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of Vitamin B.

Cyanocobalamin is the most widely used form of Vitamin B, and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract. Hydroxocobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure.

Non-Clinical Toxicology
Sensitivity to cobalt and/or Vitamin B is a contraindication.

 Flammable, keep away from fire or flame.

Vitamin B deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord. Doses of folic acid greater than 0.1 mg per day may result in hematologic remission in patients with vitamin B deficiency. Neurologic manifestations will not be prevented with folic acid, and if not treated with vitamin B, irreversible damage will result.

Doses of cyanocobalamin exceeding 10 mcg daily may produce hematologic response in patients with folate deficiency. Indiscriminate administration may mask the true diagnosis.

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Tips

Tips

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Interactions

Interactions

A total of 440 drugs (1549 brand and generic names) are known to interact with Imbruvica (ibrutinib). 228 major drug interactions (854 brand and generic names) 210 moderate drug interactions (691 brand and generic names) 2 minor drug interactions (4 brand and generic names) Show all medications in the database that may interact with Imbruvica (ibrutinib).