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norethindrone acetate and ethinyl estradiol

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Overview

What is Blisovi 24 Fe?

Blisovi 24 Fe is a combination oral contraceptive for oral administration consisting of active tablets containing norethindrone acetate, a progestin, and ethinyl estradiol, an estrogen, and placebo tablets containing ferrous fumarate, which serve no therapeutic purpose.

The chemical name of ethinyl estradiol is 19-nor-17α-pregna-1,3,5(10)-trien-20-yne-3,17-diol. The empirical formula of ethinyl estradiol is CHOand the structural formula is

The chemical name of norethindrone acetate is 17-hydroxy-19-nor-17α-pregn-4-en-20-yn-3-one acetate. The empirical formula of norethindrone acetate is CHO and the structural formula is:



What does Blisovi 24 Fe look like?



What are the available doses of Blisovi 24 Fe?

Blisovi 24 Fe consists of 28 tablets in the following order ():

What should I talk to my health care provider before I take Blisovi 24 Fe?

How should I use Blisovi 24 Fe?

Blisovi 24 Fe is indicated for use by women to prevent pregnancy

The efficacy of Blisovi 24 Fe in women with a body mass index (BMI) of > 35 kg/m has not been evaluated.

Blisovi 24 Fe is dispensed in a blister card . Blisovi 24 Fe may be started using either a Day 1 start or a Sunday start (see Table 1). For the first cycle of a Sunday Start regimen, an additional method of contraception must be used until after the first 7 consecutive days of administration.


What interacts with Blisovi 24 Fe?

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What are the warnings of Blisovi 24 Fe?

Sorry No Records found


What are the precautions of Blisovi 24 Fe?

Sorry No Records found


What are the side effects of Blisovi 24 Fe?

Sorry No records found


What should I look out for while using Blisovi 24 Fe?

Do not prescribe Blisovi 24 Fe to women who are known to have the following conditions:

■    Women over age 35 with any migraine headaches

ID581

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke


What might happen if I take too much Blisovi 24 Fe?

There have been no reports of serious ill effects from overdose of oral contraceptives, including ingestion by children. Overdosage may cause withdrawal bleeding in females and nausea.


How should I store and handle Blisovi 24 Fe?

Blisovi 24 Fe is available in a wallet (NDC 68180-864-11) containing 28 tablets packed in a pouch (NDC 68180-864-11). Such three pouches are packaged in a carton (NDC 68180-864-13).Each wallet (28 tablets) contains in the following order:Blisovi 24 Fe is available in a wallet (NDC 68180-864-11) containing 28 tablets packed in a pouch (NDC 68180-864-11). Such three pouches are packaged in a carton (NDC 68180-864-13).Each wallet (28 tablets) contains in the following order:Simvastatin Tablets USP, 40 mgBottle of 60 – 68788-9392-6Bottle of 90 – 68788-9392-9Bottle of 100 – 68788-9392-1 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Simvastatin Tablets USP, 40 mgBottle of 60 – 68788-9392-6Bottle of 90 – 68788-9392-9Bottle of 100 – 68788-9392-1 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Simvastatin Tablets USP, 40 mgBottle of 60 – 68788-9392-6Bottle of 90 – 68788-9392-9Bottle of 100 – 68788-9392-1 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].Simvastatin Tablets USP, 40 mgBottle of 60 – 68788-9392-6Bottle of 90 – 68788-9392-9Bottle of 100 – 68788-9392-1 20° to 25°C (68° to 77°F); excursions permitted to 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].


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Clinical Information

Chemical Structure

No Image found
Clinical Pharmacology

COCs lower the risk of becoming pregnant primarily by suppressing ovulation. Other possible mechanisms may include cervical mucus changes that inhibit sperm penetration and endometrial changes that reduce the likelihood of implantation.

Non-Clinical Toxicology
Do not prescribe Blisovi 24 Fe to women who are known to have the following conditions:

■    Women over age 35 with any migraine headaches

ID581

Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptive (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke

ACE-inhibitors:

Aspirin

Thrombotic Disorders and Other Vascular Problems: Stop Blisovi 24 Fe if a thrombotic event occurs. Stop at least 4 weeks before through 2 weeks after major surgery. Start no earlier than 4 weeks after delivery, in women who are not breastfeeding. ()

Liver disease: Discontinue Blisovi 24 Fe if jaundice occurs. ()

High blood pressure: If used in women with well-controlled hypertension, monitor blood pressure and stop Blisovi 24 Fe if blood pressure rises significantly. ()

Carbohydrate and lipid metabolic effects: Monitor prediabetic and diabetic women taking Blisovi 24 Fe .Consider an alternative contraceptive method for women with uncontrolled dyslipidemia. ()

Headache: Evaluate significant change in headaches and discontinue Blisovi 24 Fe if indicated. ()

Bleeding Irregularities and Amenorrhea: Evaluate irregular bleeding or amenorrhea. ()

The following serious adverse reactions with the use of COCs are discussed elsewhere in the labeling:

Adverse reactions commonly reported by COC users are:

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Reference

This information is obtained from the National Institute of Health's Standard Packaging Label drug database.
"https://dailymed.nlm.nih.gov/dailymed/"

While we update our database periodically, we cannot guarantee it is always updated to the latest version.

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Professional

Clonazepam Description Each single-scored tablet, for oral administration, contains 0.5 mg, 1 mg, or 2 mg Clonazepam, USP, a benzodiazepine. Each tablet also contains corn starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, and povidone. Clonazepam tablets USP 0.5 mg contain Yellow D&C No. 10 Aluminum Lake. Clonazepam tablets USP 1 mg contain Yellow D&C No. 10 Aluminum Lake, as well as FD&C Blue No. 1 Aluminum Lake. Chemically, Clonazepam, USP is 5-(o-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one. It is a light yellow crystalline powder. It has the following structural formula: C15H10ClN3O3 M.W. 315.72
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Interactions

Interactions

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